@article{
 title = {The management and outcomes of <i>Staphylococcus aureus</i> bacteraemia at a South African referral hospital: a prospective observational study},
 type = {article},
 year = {2018},
 identifiers = {[object Object]},
 pages = {78-84},
 volume = {73},
 websites = {https://doi.org/10.1016/j.ijid.2018.06.004},
 id = {5f020d76-f083-3226-b639-f9f34389b26c},
 created = {2018-07-17T11:45:21.401Z},
 accessed = {2018-07-13},
 file_attached = {true},
 profile_id = {50108e87-e75f-368e-a433-7bcb13a99fb7},
 group_id = {1dbe7d71-fba0-3b0e-aea3-6d28867bb4fe},
 last_modified = {2018-07-17T11:45:38.584Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 citation_key = {Steinhaus2018},
 private_publication = {false},
 abstract = {Objectives: Data on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4%; 24.0% of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0%, with 83.3% of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95% confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95% CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95% CI 1.8-52.4), female sex (OR 3.8, 95% CI 1.1-16.3), and community-acquired infection (OR 7.4, 95% CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6% of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.},
 bibtype = {article},
 author = {Steinhaus, Nicola and Al-Talib, Mohammed and Boyles, Tom and Bamford, Colleen and Davies, Mary-Ann and Mendelson, Marc and Wasserman, Sean},
 journal = {International Journal of Infectious Diseases}
}

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The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4%; 24.0% of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0%, with 83.3% of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95% confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95% CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95% CI 1.8-52.4), female sex (OR 3.8, 95% CI 1.1-16.3), and community-acquired infection (OR 7.4, 95% CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6% of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.","bibtype":"article","author":"Steinhaus, Nicola and Al-Talib, Mohammed and Boyles, Tom and Bamford, Colleen and Davies, Mary-Ann and Mendelson, Marc and Wasserman, Sean","journal":"International Journal of Infectious Diseases","bibtex":"@article{\n title = {The management and outcomes of <i>Staphylococcus aureus</i> bacteraemia at a South African referral hospital: a prospective observational study},\n type = {article},\n year = {2018},\n identifiers = {[object Object]},\n pages = {78-84},\n volume = {73},\n websites = {https://doi.org/10.1016/j.ijid.2018.06.004},\n id = {5f020d76-f083-3226-b639-f9f34389b26c},\n created = {2018-07-17T11:45:21.401Z},\n accessed = {2018-07-13},\n file_attached = {true},\n profile_id = {50108e87-e75f-368e-a433-7bcb13a99fb7},\n group_id = {1dbe7d71-fba0-3b0e-aea3-6d28867bb4fe},\n last_modified = {2018-07-17T11:45:38.584Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {false},\n hidden = {false},\n citation_key = {Steinhaus2018},\n private_publication = {false},\n abstract = {Objectives: Data on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4%; 24.0% of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0%, with 83.3% of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95% confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95% CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95% CI 1.8-52.4), female sex (OR 3.8, 95% CI 1.1-16.3), and community-acquired infection (OR 7.4, 95% CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6% of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.},\n bibtype = {article},\n author = {Steinhaus, Nicola and Al-Talib, Mohammed and Boyles, Tom and Bamford, Colleen and Davies, Mary-Ann and Mendelson, Marc and Wasserman, Sean},\n journal = {International Journal of Infectious Diseases}\n}","author_short":["Steinhaus, N.","Al-Talib, M.","Boyles, T.","Bamford, C.","Davies, M.","Mendelson, M.","Wasserman, S."],"urls":{"Paper":"https://bibbase.org/service/mendeley/50108e87-e75f-368e-a433-7bcb13a99fb7/file/5b96b7d0-ab75-ba05-2161-03d782470c7f/2018-The_management_and_outcomes_of_iStaphylococcus_aureusi_bacteraemia_at_a_South_African_referral_hospital_a_prospecti.pdf.pdf","Website":"https://doi.org/10.1016/j.ijid.2018.06.004"},"bibbaseid":"steinhaus-altalib-boyles-bamford-davies-mendelson-wasserman-themanagementandoutcomesofistaphylococcusaureusibacteraemiaatasouthafricanreferralhospitalaprospectiveobservationalstudy-2018","role":"author","downloads":0},"search_terms":["management","outcomes","staphylococcus","aureus","bacteraemia","south","african","referral","hospital","prospective","observational","study","steinhaus","al-talib","boyles","bamford","davies","mendelson","wasserman"],"keywords":[],"authorIDs":[]}