@article{Steinhaus2018,
abstract = {Objectives: Data on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4{\%}; 24.0{\%} of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0{\%}, with 83.3{\%} of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95{\%} confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95{\%} CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95{\%} CI 1.8-52.4), female sex (OR 3.8, 95{\%} CI 1.1-16.3), and community-acquired infection (OR 7.4, 95{\%} CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6{\%} of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.},
author = {Steinhaus, Nicola and Al-talib, Mohammed and Ive, Prudence and Boyles, Tom and Bamford, Colleen and Davies, Mary-Ann and Mendelson, Marc and Wasserman, Sean},
doi = {10.1016/j.ijid.2018.06.004},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Steinhaus et al. - 2018 - The management and outcomes of iStaphylococcus aureusi bacteraemia at a South African referral hospital a pros.pdf:pdf},
journal = {International Journal of Infectious Diseases},
keywords = {OA,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
pages = {78--84},
title = {{The management and outcomes of \textit{Staphylococcus aureus} bacteraemia at a South African referral hospital: a prospective observational study}},
url = {https://doi.org/10.1016/j.ijid.2018.06.004},
volume = {73},
year = {2018}
}

{"_id":"t3jRkKkMyo76DWMia","bibbaseid":"steinhaus-altalib-ive-boyles-bamford-davies-mendelson-wasserman-themanagementandoutcomesofistaphylococcusaureusibacteraemiaatasouthafricanreferralhospitalaprospectiveobservationalstudy-2018","author_short":["Steinhaus, N.","Al-talib, M.","Ive, P.","Boyles, T.","Bamford, C.","Davies, M.","Mendelson, M.","Wasserman, S."],"bibdata":{"bibtype":"article","type":"article","abstract":"Objectives: Data on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4%; 24.0% of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0%, with 83.3% of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95% confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95% CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95% CI 1.8-52.4), female sex (OR 3.8, 95% CI 1.1-16.3), and community-acquired infection (OR 7.4, 95% CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6% of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.","author":[{"propositions":[],"lastnames":["Steinhaus"],"firstnames":["Nicola"],"suffixes":[]},{"propositions":[],"lastnames":["Al-talib"],"firstnames":["Mohammed"],"suffixes":[]},{"propositions":[],"lastnames":["Ive"],"firstnames":["Prudence"],"suffixes":[]},{"propositions":[],"lastnames":["Boyles"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Bamford"],"firstnames":["Colleen"],"suffixes":[]},{"propositions":[],"lastnames":["Davies"],"firstnames":["Mary-Ann"],"suffixes":[]},{"propositions":[],"lastnames":["Mendelson"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Wasserman"],"firstnames":["Sean"],"suffixes":[]}],"doi":"10.1016/j.ijid.2018.06.004","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Steinhaus et al. - 2018 - The management and outcomes of iStaphylococcus aureusi bacteraemia at a South African referral hospital a pros.pdf:pdf","journal":"International Journal of Infectious Diseases","keywords":"OA,fund_ack,original","mendeley-tags":"OA,fund_ack,original","pages":"78–84","title":"The management and outcomes of <i>Staphylococcus aureus</i> bacteraemia at a South African referral hospital: a prospective observational study","url":"https://doi.org/10.1016/j.ijid.2018.06.004","volume":"73","year":"2018","bibtex":"@article{Steinhaus2018,\r\nabstract = {Objectives: Data on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. Methods: This was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. Results: One hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4{\\%}; 24.0{\\%} of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0{\\%}, with 83.3{\\%} of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95{\\%} confidence interval (CI) 1.0-15.1) and the presence of comorbidities (OR 4.1, 95{\\%} CI 1.0-21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95{\\%} CI 1.8-52.4), female sex (OR 3.8, 95{\\%} CI 1.1-16.3), and community-acquired infection (OR 7.4, 95{\\%} CI 2.0-33.1). Definitive antibiotic therapy was non-optimal in 22.6{\\%} of all cases. Conclusions: SAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management.},\r\nauthor = {Steinhaus, Nicola and Al-talib, Mohammed and Ive, Prudence and Boyles, Tom and Bamford, Colleen and Davies, Mary-Ann and Mendelson, Marc and Wasserman, Sean},\r\ndoi = {10.1016/j.ijid.2018.06.004},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Steinhaus et al. - 2018 - The management and outcomes of iStaphylococcus aureusi bacteraemia at a South African referral hospital a pros.pdf:pdf},\r\njournal = {International Journal of Infectious Diseases},\r\nkeywords = {OA,fund{\\_}ack,original},\r\nmendeley-tags = {OA,fund{\\_}ack,original},\r\npages = {78--84},\r\ntitle = {{The management and outcomes of \\textit{Staphylococcus aureus} bacteraemia at a South African referral hospital: a prospective observational study}},\r\nurl = {https://doi.org/10.1016/j.ijid.2018.06.004},\r\nvolume = {73},\r\nyear = {2018}\r\n}\r\n","author_short":["Steinhaus, N.","Al-talib, M.","Ive, P.","Boyles, T.","Bamford, C.","Davies, M.","Mendelson, M.","Wasserman, S."],"key":"Steinhaus2018","id":"Steinhaus2018","bibbaseid":"steinhaus-altalib-ive-boyles-bamford-davies-mendelson-wasserman-themanagementandoutcomesofistaphylococcusaureusibacteraemiaatasouthafricanreferralhospitalaprospectiveobservationalstudy-2018","role":"author","urls":{"Paper":"https://doi.org/10.1016/j.ijid.2018.06.004"},"keyword":["OA","fund_ack","original"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["oa","fund_ack","original"],"search_terms":["management","outcomes","staphylococcus","aureus","bacteraemia","south","african","referral","hospital","prospective","observational","study","steinhaus","al-talib","ive","boyles","bamford","davies","mendelson","wasserman"],"title":"The management and outcomes of <i>Staphylococcus aureus</i> bacteraemia at a South African referral hospital: a prospective observational study","year":2018}