Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone. Stek, C., Shey, M., Mnika, K., Schutz, C., Thienemann, F., Wilkinson, R. J, Lynen, L., & Meintjes, G. Open Forum Infectious Diseases, 10(7):ofad379, Oxford Academic, jul, 2023.
Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone [link]Paper  doi  abstract   bibtex   
The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
@article{Stek2023,
abstract = {The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.},
author = {Stek, Cari and Shey, Muki and Mnika, Khuthala and Schutz, Charlotte and Thienemann, Friedrich and Wilkinson, Robert J and Lynen, Lutgarde and Meintjes, Graeme},
doi = {10.1093/OFID/OFAD379},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Stek et al. - 2023 - Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syn.pdf:pdf},
issn = {23288957},
journal = {Open Forum Infectious Diseases},
keywords = {IRIS,LTA4H genotype,OA,OA{\_}PMC,corticosteroids,fund{\_}ack,immune reconstitution inflammatory syndrome,original,tuberculosis},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,original},
month = {jul},
number = {7},
pages = {ofad379},
pmid = {37520416},
publisher = {Oxford Academic},
title = {{Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone}},
url = {https://dx.doi.org/10.1093/ofid/ofad379},
volume = {10},
year = {2023}
}

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