Age dependent differences in the kinetics of gammadelta T cells after influenza vaccination. Stervbo, U., Pohlmann, D., Baron, U., Bozzetti, C., Jurchott, K., Malzer, J. N., Nienen, M., Olek, S., Roch, T., Schulz, A. R., Warth, S., Neumann, A., Thiel, A., Grutzkau, A., & Babel, N. PloS one, 12(7):e0181161, 2017. doi abstract bibtex Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly. Although gammadelta T cells can become activated by recombinant influenza hemagglutinin, their age-related immunocompetence during a virus-induced immune response has so far not been investigated. In this study we evaluate the kinetics of gammadelta T cells after vaccination with the trivalent 2011/2012 northern hemisphere seasonal influenza vaccine. We applied multi-parametric flow cytometry to a cohort of 21 young (19-30 years) and 23 elderly (53-67 years) healthy individuals. Activated and proliferating gammadelta T cells, as identified by CD38 and Ki67 expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We observed a significantly lower number of activated and proliferating gammadelta T cells at baseline and following vaccination in elderly as compared to young individuals. The kinetics changes of activated gammadelta T cells were much stronger in the young, while corresponding changes in the elderly occurred slower. In addition, we observed an association between day 21 HAI titers of influenza A and the frequencies of Ki67+ gammadelta T cells at day 7 in the young. In conclusion, aging induces alterations of the gammadelta T cell response that might have negative implications for vaccination efficacy.
@article{stervbo_age_2017,
title = {Age dependent differences in the kinetics of gammadelta {T} cells after influenza vaccination.},
volume = {12},
issn = {1932-6203 1932-6203},
doi = {10.1371/journal.pone.0181161},
abstract = {Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly. Although gammadelta T cells can become activated by recombinant influenza hemagglutinin, their age-related immunocompetence during a virus-induced immune response has so far not been investigated. In this study we evaluate the kinetics of gammadelta T cells after vaccination with the trivalent 2011/2012 northern hemisphere seasonal influenza vaccine. We applied multi-parametric flow cytometry to a cohort of 21 young (19-30 years) and 23 elderly (53-67 years) healthy individuals. Activated and proliferating gammadelta T cells, as identified by CD38 and Ki67 expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We observed a significantly lower number of activated and proliferating gammadelta T cells at baseline and following vaccination in elderly as compared to young individuals. The kinetics changes of activated gammadelta T cells were much stronger in the young, while corresponding changes in the elderly occurred slower. In addition, we observed an association between day 21 HAI titers of influenza A and the frequencies of Ki67+ gammadelta T cells at day 7 in the young. In conclusion, aging induces alterations of the gammadelta T cell response that might have negative implications for vaccination efficacy.},
language = {eng},
number = {7},
journal = {PloS one},
author = {Stervbo, Ulrik and Pohlmann, Dominika and Baron, Udo and Bozzetti, Cecilia and Jurchott, Karsten and Malzer, Julia Nora and Nienen, Mikalai and Olek, Sven and Roch, Toralf and Schulz, Axel Ronald and Warth, Sarah and Neumann, Avidan and Thiel, Andreas and Grutzkau, Andreas and Babel, Nina},
year = {2017},
pmid = {28700738},
pmcid = {PMC5507438},
keywords = {ADP-ribosyl Cyclase 1/metabolism, Adult, Aged, Aging/physiology, Female, Humans, Influenza Vaccines/*immunology, Influenza, Human/*immunology, Ki-67 Antigen/metabolism, Kinetics, Male, Middle Aged, T-Lymphocytes/*immunology, Young Adult},
pages = {e0181161}
}
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We applied multi-parametric flow cytometry to a cohort of 21 young (19-30 years) and 23 elderly (53-67 years) healthy individuals. Activated and proliferating gammadelta T cells, as identified by CD38 and Ki67 expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We observed a significantly lower number of activated and proliferating gammadelta T cells at baseline and following vaccination in elderly as compared to young individuals. The kinetics changes of activated gammadelta T cells were much stronger in the young, while corresponding changes in the elderly occurred slower. In addition, we observed an association between day 21 HAI titers of influenza A and the frequencies of Ki67+ gammadelta T cells at day 7 in the young. 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