A streamlined acquisition for mapping baseline brain oxygenation using quantitative BOLD

A streamlined acquisition for mapping baseline brain oxygenation using quantitative BOLD. Stone, A. J. & Blockley, N. P. NeuroImage, 147:79–88, February, 2017.

Paper doi abstract bibtex

Quantitative BOLD (qBOLD) is a non-invasive MR technique capable of producing quantitative measurements of the haemodynamic and metabolic properties of the brain. Here we propose a reﬁnement of the qBOLD methodology, dubbed streamlined-qBOLD, in order to provide a clinically feasible method for mapping baseline brain oxygenation. In streamlined-qBOLD confounding signal contributions are minimised during data acquisition through the application of (i) a Fluid Attenuated Inversion Recovery (FLAIR) preparation to remove cerebral spinal ﬂuid (CSF) signal contamination, (ii) a Gradient Echo Slice Excitation Proﬁle Imaging (GESEPI) acquisition to reduce the eﬀect of macroscopic magnetic ﬁeld gradients and (iii) an Asymmetric Spin Echo (ASE) pulse sequence to directly measure the reversible transverse relaxation rate, R2′. Together these features simplify the application of the qBOLD model, improving the robustness of the resultant parametric maps. A theoretical optimisation framework was used to optimise acquisition parameters in relation to signal to noise ratio. In a healthy subject group (n = 7) apparent elevations in R2′ caused by partial volumes of CSF were shown to be reduced with the application of CSF nulling. Signiﬁcant decreases in R2′ (p \textless 0.001) and deoxygenated blood volume (p \textless 0.01) were seen in cortical grey matter, across the group, with the application of CSF suppression. Quantitative baseline brain oxygenation parameter maps were calculated using qBOLD modelling and compared with literature values.

@article{stone_streamlined_2017,
	title = {A streamlined acquisition for mapping baseline brain oxygenation using quantitative {BOLD}},
	volume = {147},
	issn = {10538119},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S1053811916306759},
	doi = {10.1016/j.neuroimage.2016.11.057},
	abstract = {Quantitative BOLD (qBOLD) is a non-invasive MR technique capable of producing quantitative measurements of the haemodynamic and metabolic properties of the brain. Here we propose a reﬁnement of the qBOLD methodology, dubbed streamlined-qBOLD, in order to provide a clinically feasible method for mapping baseline brain oxygenation. In streamlined-qBOLD confounding signal contributions are minimised during data acquisition through the application of (i) a Fluid Attenuated Inversion Recovery (FLAIR) preparation to remove cerebral spinal ﬂuid (CSF) signal contamination, (ii) a Gradient Echo Slice Excitation Proﬁle Imaging (GESEPI) acquisition to reduce the eﬀect of macroscopic magnetic ﬁeld gradients and (iii) an Asymmetric Spin Echo (ASE) pulse sequence to directly measure the reversible transverse relaxation rate, R2′. Together these features simplify the application of the qBOLD model, improving the robustness of the resultant parametric maps. A theoretical optimisation framework was used to optimise acquisition parameters in relation to signal to noise ratio. In a healthy subject group (n = 7) apparent elevations in R2′ caused by partial volumes of CSF were shown to be reduced with the application of CSF nulling. Signiﬁcant decreases in R2′ (p {\textless} 0.001) and deoxygenated blood volume (p {\textless} 0.01) were seen in cortical grey matter, across the group, with the application of CSF suppression. Quantitative baseline brain oxygenation parameter maps were calculated using qBOLD modelling and compared with literature values.},
	language = {en},
	urldate = {2021-02-12},
	journal = {NeuroImage},
	author = {Stone, Alan J. and Blockley, Nicholas P.},
	month = feb,
	year = {2017},
	pages = {79--88},
}

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