Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Strom, N., Verhulst, B., Bacanu, S., Cheesman, R., Purves, K., Gedik, H., Mitchell, B., Kwong, A., Faucon, A., Singh, K., Medland, S., Colodro-Conde, L., Krebs, K., Hoffmann, P., Herms, S., Gehlen, J., Ripke, S., Awasthi, S., Palviainen, T., Tasanko, E., Peterson, R., Adkins, D., Shabalin, A., Adams, M., Iveson, M., Campbell, A., Thomas, L., Winsvold, B., Drange, O., Børte, S., ter Kuile, A., Naamanka, J., Nguyen, T., Meier, S., Corfield, E., Hannigan, L., Levey, D., Czamara, D., Weber, H., Choi, K., Pistis, G., Couvy-Duchesne, B., van der Auwera, S., Teumer, A., Karlsson, R., Garcia-Argibay, M., Lee, D., Wang, R., Bjerkeset, O., Stordal, E., Bäckman, J., Salum Junior, G., Zai, C., Kennedy, J., Zai, G., Tiwari, A., Heilmann-Heimbach, S., Schmidt, B., Kaprio, J., Kennedy, M., Boden, J., Havdahl, A., Middeldorp, C., Lopes, F., Akula, N., McMahon, F., Binder, E., Fehm, L., Ströhle, A., Castelao, E., Tiemeier, H., Stein, D., Whiteman, D., Olsen, C., Fuller, Z., Wang, X., Wray, N., Byrne, E., Lewis, G., Timpson, N., Davis, L., Hickie, I., Gillespie, N., Milani, L., Schumacher, J., Woldbye, D., Forstner, A., Nöthen, M., Hovatta, I., Horwood, J., Copeland, W., Maes, H., McIntosh, A., Andreassen, O., Zwart, J., Mors, O., BØRglum, A., Mortensen, P., Ask, H., & Reichborn-Kjennerud, T. Nature Genetics, 2026.

Paper doi bibtex

@article{strom_genome-wide_2026,
	title = {Genome-wide association study of major anxiety disorders in 122,341 {European}-ancestry cases identifies 58 loci and highlights {GABAergic} signaling},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105029474297&doi=10.1038%2Fs41588-025-02485-8&partnerID=40&md5=47949611ff18102435bb09ab180723be},
	doi = {10.1038/s41588-025-02485-8},
	journal = {Nature Genetics},
	author = {Strom, N.I. and Verhulst, B. and Bacanu, S.-A. and Cheesman, R. and Purves, K.L. and Gedik, H. and Mitchell, B.L. and Kwong, A.S. and Faucon, A.B. and Singh, K. and Medland, S.E. and Colodro-Conde, L. and Krebs, K. and Hoffmann, P. and Herms, S. and Gehlen, J. and Ripke, S. and Awasthi, S. and Palviainen, T. and Tasanko, E. and Peterson, R.E. and Adkins, D.E. and Shabalin, A.A. and Adams, M.J. and Iveson, M.H. and Campbell, A. and Thomas, L. and Winsvold, B.S. and Drange, O.K. and Børte, S. and ter Kuile, A.R. and Naamanka, J. and Nguyen, T.-H. and Meier, S.M. and Corfield, E.C. and Hannigan, L. and Levey, D.F. and Czamara, D. and Weber, H. and Choi, K.W. and Pistis, G. and Couvy-Duchesne, B. and van der Auwera, S. and Teumer, A. and Karlsson, R. and Garcia-Argibay, M. and Lee, D. and Wang, R. and Bjerkeset, O. and Stordal, E. and Bäckman, J. and Salum Junior, G.A. and Zai, C.C. and Kennedy, J.L. and Zai, G. and Tiwari, A.K. and Heilmann-Heimbach, S. and Schmidt, B. and Kaprio, J. and Kennedy, M.M. and Boden, J. and Havdahl, A. and Middeldorp, C.M. and Lopes, F.L. and Akula, N. and McMahon, F.J. and Binder, E.B. and Fehm, L. and Ströhle, A. and Castelao, E. and Tiemeier, H. and Stein, D.J. and Whiteman, D. and Olsen, C. and Fuller, Z. and Wang, X. and Wray, N.R. and Byrne, E.M. and Lewis, G. and Timpson, N.J. and Davis, L.K. and Hickie, I.B. and Gillespie, N.A. and Milani, L. and Schumacher, J. and Woldbye, D.P. and Forstner, A.J. and Nöthen, M.M. and Hovatta, I. and Horwood, J. and Copeland, W.E. and Maes, H.H.M. and McIntosh, A.M. and Andreassen, O.A. and Zwart, J.-A. and Mors, O. and BØRglum, A.D. and Mortensen, P.B. and Ask, H. and Reichborn-Kjennerud, T.},
	year = {2026},
}

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