@article{struglics_changes_2018,
	title = {Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the {KANON} trial},
	volume = {26},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2018.06.005},
	abstract = {OBJECTIVE: To monitor longitudinal changes of cartilage oligomeric matrix protein (COMP) in synovial fluid (sf) and serum (s) over 5 years after acute anterior cruciate ligament (ACL) rupture, and to compare results from two commercial COMP immunoassays.
DESIGN: Bio-fluids were collected from 121 patients on six occasions over 5 years after acute ACL injury, and from 25 knee healthy reference subjects. Concentrations of sf- and sCOMP were measured by AnaMar (sCOMP-Ana) and by BioVendor (sf- and sCOMP-Bio) immunoassays; other biomarkers were previously assessed. We used ANCOVA for group comparisons and linear mixed models for associations between biomarkers over 5-years with P {\textless} 0.05 considered a statistically significant difference or association.
RESULTS: Compared to the reference group, sfCOMP-Bio concentrations were 2-fold elevated within 6 weeks after ACL injury and remained elevated 5 years thereafter, whereas sCOMP-Bio and sCOMP-Ana concentrations were no different from reference levels at any time point. Over the 5-year period, there was an association between sCOMP-Bio and sCOMP-Ana concentrations, although neither sCOMP-Bio nor sCOMP-Ana associated with sfCOMP-Bio. sfCOMP-Bio associated with SF ARGS-aggrecan, urine type I and II collagens (uNTX-I and uCTX-II) and SF cytokines, while sCOMP-Bio associated inversely with uCTX-II, uNTX-I and SF cytokines.
CONCLUSION: The local process after an acute ACL injury generates increased SF COMP concentrations in the injured knee up to 5 years after injury. This response is not detected in serum. Discrepancies in associations between sCOMP measured by BioVendor and AnaMar immunoassays with other biomarkers indicate differences in detected COMP fragments.},
	language = {eng},
	number = {10},
	journal = {Osteoarthritis and Cartilage},
	author = {Struglics, A. and Larsson, S. and Pramhed, A. and Frobell, R. and Swärd, P.},
	year = {2018},
	pmid = {29958916},
	keywords = {ACL injury, Biomarkers, COMP, Synovial fluid},
	pages = {1351--1358},
}

{"_id":"XN5my37vzYz3rsquA","bibbaseid":"struglics-larsson-pramhed-frobell-swrd-changesinsynovialfluidandserumconcentrationsofcartilageoligomericmatrixproteinover5yearsafteranteriorcruciateligamentruptureanexploratoryanalysisinthekanontrial-2018","authorIDs":[],"author_short":["Struglics, A.","Larsson, S.","Pramhed, A.","Frobell, R.","Swärd, P."],"bibdata":{"bibtype":"article","type":"article","title":"Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial","volume":"26","issn":"1522-9653","doi":"10.1016/j.joca.2018.06.005","abstract":"OBJECTIVE: To monitor longitudinal changes of cartilage oligomeric matrix protein (COMP) in synovial fluid (sf) and serum (s) over 5 years after acute anterior cruciate ligament (ACL) rupture, and to compare results from two commercial COMP immunoassays. DESIGN: Bio-fluids were collected from 121 patients on six occasions over 5 years after acute ACL injury, and from 25 knee healthy reference subjects. Concentrations of sf- and sCOMP were measured by AnaMar (sCOMP-Ana) and by BioVendor (sf- and sCOMP-Bio) immunoassays; other biomarkers were previously assessed. We used ANCOVA for group comparisons and linear mixed models for associations between biomarkers over 5-years with P \\textless 0.05 considered a statistically significant difference or association. RESULTS: Compared to the reference group, sfCOMP-Bio concentrations were 2-fold elevated within 6 weeks after ACL injury and remained elevated 5 years thereafter, whereas sCOMP-Bio and sCOMP-Ana concentrations were no different from reference levels at any time point. Over the 5-year period, there was an association between sCOMP-Bio and sCOMP-Ana concentrations, although neither sCOMP-Bio nor sCOMP-Ana associated with sfCOMP-Bio. sfCOMP-Bio associated with SF ARGS-aggrecan, urine type I and II collagens (uNTX-I and uCTX-II) and SF cytokines, while sCOMP-Bio associated inversely with uCTX-II, uNTX-I and SF cytokines. CONCLUSION: The local process after an acute ACL injury generates increased SF COMP concentrations in the injured knee up to 5 years after injury. This response is not detected in serum. Discrepancies in associations between sCOMP measured by BioVendor and AnaMar immunoassays with other biomarkers indicate differences in detected COMP fragments.","language":"eng","number":"10","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Struglics"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Larsson"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Pramhed"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Frobell"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Swärd"],"firstnames":["P."],"suffixes":[]}],"year":"2018","pmid":"29958916","keywords":"ACL injury, Biomarkers, COMP, Synovial fluid","pages":"1351–1358","bibtex":"@article{struglics_changes_2018,\n\ttitle = {Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the {KANON} trial},\n\tvolume = {26},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2018.06.005},\n\tabstract = {OBJECTIVE: To monitor longitudinal changes of cartilage oligomeric matrix protein (COMP) in synovial fluid (sf) and serum (s) over 5 years after acute anterior cruciate ligament (ACL) rupture, and to compare results from two commercial COMP immunoassays.\nDESIGN: Bio-fluids were collected from 121 patients on six occasions over 5 years after acute ACL injury, and from 25 knee healthy reference subjects. Concentrations of sf- and sCOMP were measured by AnaMar (sCOMP-Ana) and by BioVendor (sf- and sCOMP-Bio) immunoassays; other biomarkers were previously assessed. We used ANCOVA for group comparisons and linear mixed models for associations between biomarkers over 5-years with P {\\textless} 0.05 considered a statistically significant difference or association.\nRESULTS: Compared to the reference group, sfCOMP-Bio concentrations were 2-fold elevated within 6 weeks after ACL injury and remained elevated 5 years thereafter, whereas sCOMP-Bio and sCOMP-Ana concentrations were no different from reference levels at any time point. Over the 5-year period, there was an association between sCOMP-Bio and sCOMP-Ana concentrations, although neither sCOMP-Bio nor sCOMP-Ana associated with sfCOMP-Bio. sfCOMP-Bio associated with SF ARGS-aggrecan, urine type I and II collagens (uNTX-I and uCTX-II) and SF cytokines, while sCOMP-Bio associated inversely with uCTX-II, uNTX-I and SF cytokines.\nCONCLUSION: The local process after an acute ACL injury generates increased SF COMP concentrations in the injured knee up to 5 years after injury. This response is not detected in serum. Discrepancies in associations between sCOMP measured by BioVendor and AnaMar immunoassays with other biomarkers indicate differences in detected COMP fragments.},\n\tlanguage = {eng},\n\tnumber = {10},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Struglics, A. and Larsson, S. and Pramhed, A. and Frobell, R. and Swärd, P.},\n\tyear = {2018},\n\tpmid = {29958916},\n\tkeywords = {ACL injury, Biomarkers, COMP, Synovial fluid},\n\tpages = {1351--1358},\n}\n\n","author_short":["Struglics, A.","Larsson, S.","Pramhed, A.","Frobell, R.","Swärd, P."],"key":"struglics_changes_2018","id":"struglics_changes_2018","bibbaseid":"struglics-larsson-pramhed-frobell-swrd-changesinsynovialfluidandserumconcentrationsofcartilageoligomericmatrixproteinover5yearsafteranteriorcruciateligamentruptureanexploratoryanalysisinthekanontrial-2018","role":"author","urls":{},"keyword":["ACL injury","Biomarkers","COMP","Synovial fluid"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/ClinEpiLU","creationDate":"2020-10-01T07:01:00.556Z","downloads":0,"keywords":["acl injury","biomarkers","comp","synovial fluid"],"search_terms":["changes","synovial","fluid","serum","concentrations","cartilage","oligomeric","matrix","protein","over","years","anterior","cruciate","ligament","rupture","exploratory","analysis","kanon","trial","struglics","larsson","pramhed","frobell","swärd"],"title":"Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial","year":2018,"dataSources":["z8zMpgTxRJJJ4r8zb","5jEuhQhgRx3py8LmG"]}