@article{struglics_molecular_2020,
	title = {Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years},
	volume = {28},
	issn = {1522-9653},
	url = {https://doi.org/10.1016/j.joca.2019.12.010},
	doi = {10.1016/j.joca.2019.12.010},
	abstract = {OBJECTIVE: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years.
METHODS: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses.
RESULTS: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95\% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years.
CONCLUSION: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes.},
	language = {eng},
	number = {3},
	journal = {Osteoarthritis and Cartilage},
	author = {Struglics, A. and Turkiewicz, A. and Larsson, S. and Lohmander, L. S. and Roemer, F. W. and Frobell, R. and Englund, M.},
	year = {2020},
	pmid = {31940458},
	keywords = {Anterior cruciate ligament injury, Biomarkers, Inflammation, Patient reported outcomes, Synovitis},
	pages = {356--362},
}

{"_id":"xjkvJfLEihAAYnokT","bibbaseid":"struglics-turkiewicz-larsson-lohmander-roemer-frobell-englund-molecularandimagingbiomarkersoflocalinflammationat2yearsafteranteriorcruciateligamentinjurydonotassociatewithpatientreportedoutcomesat5years-2020","author_short":["Struglics, A.","Turkiewicz, A.","Larsson, S.","Lohmander, L. S.","Roemer, F. W.","Frobell, R.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years","volume":"28","issn":"1522-9653","url":"https://doi.org/10.1016/j.joca.2019.12.010","doi":"10.1016/j.joca.2019.12.010","abstract":"OBJECTIVE: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. METHODS: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses. RESULTS: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years. CONCLUSION: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes.","language":"eng","number":"3","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Struglics"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Larsson"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Lohmander"],"firstnames":["L.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Roemer"],"firstnames":["F.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Frobell"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]}],"year":"2020","pmid":"31940458","keywords":"Anterior cruciate ligament injury, Biomarkers, Inflammation, Patient reported outcomes, Synovitis","pages":"356–362","bibtex":"@article{struglics_molecular_2020,\n\ttitle = {Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years},\n\tvolume = {28},\n\tissn = {1522-9653},\n\turl = {https://doi.org/10.1016/j.joca.2019.12.010},\n\tdoi = {10.1016/j.joca.2019.12.010},\n\tabstract = {OBJECTIVE: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years.\nMETHODS: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses.\nRESULTS: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95\\% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years.\nCONCLUSION: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Struglics, A. and Turkiewicz, A. and Larsson, S. and Lohmander, L. S. and Roemer, F. W. and Frobell, R. and Englund, M.},\n\tyear = {2020},\n\tpmid = {31940458},\n\tkeywords = {Anterior cruciate ligament injury, Biomarkers, Inflammation, Patient reported outcomes, Synovitis},\n\tpages = {356--362},\n}\n\n","author_short":["Struglics, A.","Turkiewicz, A.","Larsson, S.","Lohmander, L. S.","Roemer, F. W.","Frobell, R.","Englund, M."],"key":"struglics_molecular_2020","id":"struglics_molecular_2020","bibbaseid":"struglics-turkiewicz-larsson-lohmander-roemer-frobell-englund-molecularandimagingbiomarkersoflocalinflammationat2yearsafteranteriorcruciateligamentinjurydonotassociatewithpatientreportedoutcomesat5years-2020","role":"author","urls":{"Paper":"https://doi.org/10.1016/j.joca.2019.12.010"},"keyword":["Anterior cruciate ligament injury","Biomarkers","Inflammation","Patient reported outcomes","Synovitis"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/799289/items?key=DE7AwkgUPeLruRBgvUzdo0Xc&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","NGDbv8dMYDaDn8kqm","5jEuhQhgRx3py8LmG"],"keywords":["anterior cruciate ligament injury","biomarkers","inflammation","patient reported outcomes","synovitis"],"search_terms":["molecular","imaging","biomarkers","local","inflammation","years","anterior","cruciate","ligament","injury","associate","patient","reported","outcomes","years","struglics","turkiewicz","larsson","lohmander","roemer","frobell","englund"],"title":"Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years","year":2020}