Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors. Stucci, L. S., D'Oronzo, S., Tucci, M., Macerollo, A., Ribero, S., Spagnolo, F., Marra, E., Picasso, V., Orgiano, L., Marconcini, R., De Rosa, F., Di Guardo, L., Galli, G., Gandini, S., Palmirotta, R., Palmieri, G., Queirolo, P., Silvestris, F., & Italian Melanoma Intergroup (IMI) Cancer Treatment Reviews, 69:21–28, September, 2018. doi abstract bibtex The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.
@article{stucci_vitamin_2018,
title = {Vitamin {D} in melanoma: {Controversies} and potential role in combination with immune check-point inhibitors},
volume = {69},
issn = {1532-1967},
shorttitle = {Vitamin {D} in melanoma},
doi = {10.1016/j.ctrv.2018.05.016},
abstract = {The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.},
language = {eng},
journal = {Cancer Treatment Reviews},
author = {Stucci, Luigia Stefania and D'Oronzo, Stella and Tucci, Marco and Macerollo, Antonella and Ribero, Simone and Spagnolo, Francesco and Marra, Elena and Picasso, Virginia and Orgiano, Laura and Marconcini, Riccardo and De Rosa, Francesco and Di Guardo, Lorenza and Galli, Giulia and Gandini, Sara and Palmirotta, Raffaele and Palmieri, Giuseppe and Queirolo, Paola and Silvestris, Francesco and {Italian Melanoma Intergroup (IMI)}},
month = sep,
year = {2018},
pmid = {29864718},
keywords = {Antibodies, Monoclonal, B7-H1 Antigen, CTLA-4 Antigen, Drug Therapy, Combination, Humans, Immune check-point inhibitors, Immune related adverse events, Melanoma, PDL-1, Prognosis, Vitamin D},
pages = {21--28},
}
Downloads: 0
{"_id":"txYcZdMADd93AHyJn","bibbaseid":"stucci-doronzo-tucci-macerollo-ribero-spagnolo-marra-picasso-etal-vitamindinmelanomacontroversiesandpotentialroleincombinationwithimmunecheckpointinhibitors-2018","author_short":["Stucci, L. S.","D'Oronzo, S.","Tucci, M.","Macerollo, A.","Ribero, S.","Spagnolo, F.","Marra, E.","Picasso, V.","Orgiano, L.","Marconcini, R.","De Rosa, F.","Di Guardo, L.","Galli, G.","Gandini, S.","Palmirotta, R.","Palmieri, G.","Queirolo, P.","Silvestris, F.","Italian Melanoma Intergroup (IMI)"],"bibdata":{"bibtype":"article","type":"article","title":"Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors","volume":"69","issn":"1532-1967","shorttitle":"Vitamin D in melanoma","doi":"10.1016/j.ctrv.2018.05.016","abstract":"The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.","language":"eng","journal":"Cancer Treatment Reviews","author":[{"propositions":[],"lastnames":["Stucci"],"firstnames":["Luigia","Stefania"],"suffixes":[]},{"propositions":[],"lastnames":["D'Oronzo"],"firstnames":["Stella"],"suffixes":[]},{"propositions":[],"lastnames":["Tucci"],"firstnames":["Marco"],"suffixes":[]},{"propositions":[],"lastnames":["Macerollo"],"firstnames":["Antonella"],"suffixes":[]},{"propositions":[],"lastnames":["Ribero"],"firstnames":["Simone"],"suffixes":[]},{"propositions":[],"lastnames":["Spagnolo"],"firstnames":["Francesco"],"suffixes":[]},{"propositions":[],"lastnames":["Marra"],"firstnames":["Elena"],"suffixes":[]},{"propositions":[],"lastnames":["Picasso"],"firstnames":["Virginia"],"suffixes":[]},{"propositions":[],"lastnames":["Orgiano"],"firstnames":["Laura"],"suffixes":[]},{"propositions":[],"lastnames":["Marconcini"],"firstnames":["Riccardo"],"suffixes":[]},{"propositions":[],"lastnames":["De","Rosa"],"firstnames":["Francesco"],"suffixes":[]},{"propositions":[],"lastnames":["Di","Guardo"],"firstnames":["Lorenza"],"suffixes":[]},{"propositions":[],"lastnames":["Galli"],"firstnames":["Giulia"],"suffixes":[]},{"propositions":[],"lastnames":["Gandini"],"firstnames":["Sara"],"suffixes":[]},{"propositions":[],"lastnames":["Palmirotta"],"firstnames":["Raffaele"],"suffixes":[]},{"propositions":[],"lastnames":["Palmieri"],"firstnames":["Giuseppe"],"suffixes":[]},{"propositions":[],"lastnames":["Queirolo"],"firstnames":["Paola"],"suffixes":[]},{"propositions":[],"lastnames":["Silvestris"],"firstnames":["Francesco"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Italian Melanoma Intergroup (IMI)"],"suffixes":[]}],"month":"September","year":"2018","pmid":"29864718","keywords":"Antibodies, Monoclonal, B7-H1 Antigen, CTLA-4 Antigen, Drug Therapy, Combination, Humans, Immune check-point inhibitors, Immune related adverse events, Melanoma, PDL-1, Prognosis, Vitamin D","pages":"21–28","bibtex":"@article{stucci_vitamin_2018,\n\ttitle = {Vitamin {D} in melanoma: {Controversies} and potential role in combination with immune check-point inhibitors},\n\tvolume = {69},\n\tissn = {1532-1967},\n\tshorttitle = {Vitamin {D} in melanoma},\n\tdoi = {10.1016/j.ctrv.2018.05.016},\n\tabstract = {The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.},\n\tlanguage = {eng},\n\tjournal = {Cancer Treatment Reviews},\n\tauthor = {Stucci, Luigia Stefania and D'Oronzo, Stella and Tucci, Marco and Macerollo, Antonella and Ribero, Simone and Spagnolo, Francesco and Marra, Elena and Picasso, Virginia and Orgiano, Laura and Marconcini, Riccardo and De Rosa, Francesco and Di Guardo, Lorenza and Galli, Giulia and Gandini, Sara and Palmirotta, Raffaele and Palmieri, Giuseppe and Queirolo, Paola and Silvestris, Francesco and {Italian Melanoma Intergroup (IMI)}},\n\tmonth = sep,\n\tyear = {2018},\n\tpmid = {29864718},\n\tkeywords = {Antibodies, Monoclonal, B7-H1 Antigen, CTLA-4 Antigen, Drug Therapy, Combination, Humans, Immune check-point inhibitors, Immune related adverse events, Melanoma, PDL-1, Prognosis, Vitamin D},\n\tpages = {21--28},\n}\n\n","author_short":["Stucci, L. S.","D'Oronzo, S.","Tucci, M.","Macerollo, A.","Ribero, S.","Spagnolo, F.","Marra, E.","Picasso, V.","Orgiano, L.","Marconcini, R.","De Rosa, F.","Di Guardo, L.","Galli, G.","Gandini, S.","Palmirotta, R.","Palmieri, G.","Queirolo, P.","Silvestris, F.","Italian Melanoma Intergroup (IMI)"],"key":"stucci_vitamin_2018","id":"stucci_vitamin_2018","bibbaseid":"stucci-doronzo-tucci-macerollo-ribero-spagnolo-marra-picasso-etal-vitamindinmelanomacontroversiesandpotentialroleincombinationwithimmunecheckpointinhibitors-2018","role":"author","urls":{},"keyword":["Antibodies","Monoclonal","B7-H1 Antigen","CTLA-4 Antigen","Drug Therapy","Combination","Humans","Immune check-point inhibitors","Immune related adverse events","Melanoma","PDL-1","Prognosis","Vitamin D"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/585595/collections/HCQRL7V9/items?key=ubq1R9YBMh4WxLV9o11xNG5E&format=bibtex&limit=100","dataSources":["Zb6yF7Tzr9cMwsuEA"],"keywords":["antibodies","monoclonal","b7-h1 antigen","ctla-4 antigen","drug therapy","combination","humans","immune check-point inhibitors","immune related adverse events","melanoma","pdl-1","prognosis","vitamin d"],"search_terms":["vitamin","melanoma","controversies","potential","role","combination","immune","check","point","inhibitors","stucci","d'oronzo","tucci","macerollo","ribero","spagnolo","marra","picasso","orgiano","marconcini","de rosa","di guardo","galli","gandini","palmirotta","palmieri","queirolo","silvestris","italian melanoma intergroup (imi)"],"title":"Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors","year":2018}