Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure. Stutz, M. R., Dylla, N. P., Pearson, S. D., Lecompte-Osorio, P., Nayak, R., Khalid, M., Adler, E., Boissiere, J., Lin, H., Leiter, W., Little, J., Rose, A., Moran, D., Mullowney, M. W., Wolfe, K. S., Lehmann, C., Odenwald, M., De La Cruz, M., Giurcanu, M., Pohlman, A. S., Hall, J. B., Chaubard, J., Sundararajan, A., Sidebottom, A., Kress, J. P., Pamer, E. G., & Patel, B. K. Nature Communications, 13(1):6615, Nature Publishing Group, November, 2022.
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure [link]Paper  doi  abstract   bibtex   
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains unclear. We prospectively enrolled 71 patients with COVID-19 associated critical illness, collected fecal specimens within 3 days of medical intensive care unit admission, defined microbiome compositions by shotgun metagenomic sequencing, and quantified microbiota-derived metabolites (NCT #04552834). Of the 71 patients, 39 survived and 32 died. Mortality was associated with increased representation of Proteobacteria in the fecal microbiota and decreased concentrations of fecal secondary bile acids and desaminotyrosine (DAT). A microbiome metabolic profile (MMP) that accounts for fecal secondary bile acids and desaminotyrosine concentrations was independently associated with progression of respiratory failure leading to mechanical ventilation. Our findings demonstrate that fecal microbiota composition and microbiota-derived metabolite concentrations can predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection and suggest that the gut-lung axis plays an important role in the recovery from COVID-19.
@article{stutz_immunomodulatory_2022,
	title = {Immunomodulatory fecal metabolites are associated with mortality in {COVID}-19 patients with respiratory failure},
	volume = {13},
	copyright = {2022 The Author(s)},
	issn = {2041-1723},
	url = {https://www.nature.com/articles/s41467-022-34260-2},
	doi = {10.1038/s41467-022-34260-2},
	abstract = {Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains unclear. We prospectively enrolled 71 patients with COVID-19 associated critical illness, collected fecal specimens within 3 days of medical intensive care unit admission, defined microbiome compositions by shotgun metagenomic sequencing, and quantified microbiota-derived metabolites (NCT \#04552834). Of the 71 patients, 39 survived and 32 died. Mortality was associated with increased representation of Proteobacteria in the fecal microbiota and decreased concentrations of fecal secondary bile acids and desaminotyrosine (DAT). A microbiome metabolic profile (MMP) that accounts for fecal secondary bile acids and desaminotyrosine concentrations was independently associated with progression of respiratory failure leading to mechanical ventilation. Our findings demonstrate that fecal microbiota composition and microbiota-derived metabolite concentrations can predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection and suggest that the gut-lung axis plays an important role in the recovery from COVID-19.},
	language = {en},
	number = {1},
	urldate = {2025-12-23},
	journal = {Nature Communications},
	publisher = {Nature Publishing Group},
	author = {Stutz, Matthew R. and Dylla, Nicholas P. and Pearson, Steven D. and Lecompte-Osorio, Paola and Nayak, Ravi and Khalid, Maryam and Adler, Emerald and Boissiere, Jaye and Lin, Huaiying and Leiter, William and Little, Jessica and Rose, Amber and Moran, David and Mullowney, Michael W. and Wolfe, Krysta S. and Lehmann, Christopher and Odenwald, Matthew and De La Cruz, Mark and Giurcanu, Mihai and Pohlman, Anne S. and Hall, Jesse B. and Chaubard, Jean-Luc and Sundararajan, Anitha and Sidebottom, Ashley and Kress, John P. and Pamer, Eric G. and Patel, Bhakti K.},
	month = nov,
	year = {2022},
	keywords = {Microbiology, Viral infection},
	pages = {6615},
}
Downloads: 0
About
Documentation
Keywords
Search
Users
Terms and Conditions of Use
Privacy Policy
Sitemap
© BibBase.org 2021