Double dissociation of short-term and long-term memory for nonverbal material in Parkinson's disease and global amnesia. A further analysis. Sullivan, E. V. & Sagar, H. J. Brain, 114 ( Pt 2):893–906, 1991. abstract bibtex The traditional concept of memory disorder is deficiency of the long-term (LTM) but not short-term (STM) component of memory. STM impairment with LTM sparing is seldom reported. The present study investigated STM and LTM for nonverbal material in three neurological conditions associated with memory impairment: bilateral medial temporal lobe lesions (patient H.M.), Parkinson's disease (PD) and Alzheimer's disease (AD). Subjects received 3 tests of nonverbal memory: forward block span, immediate and delayed recall of the Wechsler Memory Scale drawings, and immediate and delayed recognition of abstract designs. Compared with the normal control group, the patient groups displayed different patterns of sparing and loss of the two components of memory: in PD, only STM was impaired; in medial temporal lobe amnesia, only LTM was impaired; and in AD, STM and LTM were both impaired. The contrasting patterns of sparing and loss of STM and LTM in PD and global amnesia were present for both recognition and recall. These results provide evidence that STM and LTM are dissociable processes and are served by separate neurological systems: STM depends upon intact corticostriatal systems, whereas LTM depends upon intact medial temporal lobe systems.
@Article{Sullivan1991,
author = {Sullivan, E. V. and Sagar, H. J.},
journal = {Brain},
title = {Double dissociation of short-term and long-term memory for nonverbal material in Parkinson's disease and global amnesia. A further analysis.},
year = {1991},
pages = {893--906},
volume = {114 ( Pt 2)},
abstract = {The traditional concept of memory disorder is deficiency of the long-term
(LTM) but not short-term (STM) component of memory. STM impairment
with LTM sparing is seldom reported. The present study investigated
STM and LTM for nonverbal material in three neurological conditions
associated with memory impairment: bilateral medial temporal lobe
lesions (patient H.M.), Parkinson's disease (PD) and Alzheimer's
disease (AD). Subjects received 3 tests of nonverbal memory: forward
block span, immediate and delayed recall of the Wechsler Memory Scale
drawings, and immediate and delayed recognition of abstract designs.
Compared with the normal control group, the patient groups displayed
different patterns of sparing and loss of the two components of memory:
in PD, only STM was impaired; in medial temporal lobe amnesia, only
LTM was impaired; and in AD, STM and LTM were both impaired. The
contrasting patterns of sparing and loss of STM and LTM in PD and
global amnesia were present for both recognition and recall. These
results provide evidence that STM and LTM are dissociable processes
and are served by separate neurological systems: STM depends upon
intact corticostriatal systems, whereas LTM depends upon intact medial
temporal lobe systems.},
institution = {Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge.},
keywords = {Aged; Amnesia, psychology; Analysis of Variance; Humans; Memory; Memory Disorders, etiology; Memory, Short-Term; Middle Aged; Parkinson Disease, psychology; Reference Values; Wechsler Scales},
language = {eng},
medline-pst = {ppublish},
pmid = {2043956},
timestamp = {2012.06.11},
}
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The present study investigated STM and LTM for nonverbal material in three neurological conditions associated with memory impairment: bilateral medial temporal lobe lesions (patient H.M.), Parkinson's disease (PD) and Alzheimer's disease (AD). Subjects received 3 tests of nonverbal memory: forward block span, immediate and delayed recall of the Wechsler Memory Scale drawings, and immediate and delayed recognition of abstract designs. Compared with the normal control group, the patient groups displayed different patterns of sparing and loss of the two components of memory: in PD, only STM was impaired; in medial temporal lobe amnesia, only LTM was impaired; and in AD, STM and LTM were both impaired. The contrasting patterns of sparing and loss of STM and LTM in PD and global amnesia were present for both recognition and recall. 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A further analysis.},\n year = {1991},\n pages = {893--906},\n volume = {114 ( Pt 2)},\n abstract = {The traditional concept of memory disorder is deficiency of the long-term\n\t(LTM) but not short-term (STM) component of memory. STM impairment\n\twith LTM sparing is seldom reported. The present study investigated\n\tSTM and LTM for nonverbal material in three neurological conditions\n\tassociated with memory impairment: bilateral medial temporal lobe\n\tlesions (patient H.M.), Parkinson's disease (PD) and Alzheimer's\n\tdisease (AD). Subjects received 3 tests of nonverbal memory: forward\n\tblock span, immediate and delayed recall of the Wechsler Memory Scale\n\tdrawings, and immediate and delayed recognition of abstract designs.\n\tCompared with the normal control group, the patient groups displayed\n\tdifferent patterns of sparing and loss of the two components of memory:\n\tin PD, only STM was impaired; in medial temporal lobe amnesia, only\n\tLTM was impaired; and in AD, STM and LTM were both impaired. The\n\tcontrasting patterns of sparing and loss of STM and LTM in PD and\n\tglobal amnesia were present for both recognition and recall. 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