Agonist E-6837 and antagonist SB-271046 of 5-HT6 receptors both reverse the depressive-like effect induced in mice by subchronic ketamine administration. Suárez-Santiago, J. E., Briones-Aranda, A., Espinosa-Raya, J., & Picazo, O. Behavioural Pharmacology, 28(7):582–585, October, 2017. Number: 7doi abstract bibtex Major depression is one of the most common affective disorders caused by schizophrenia. The administration of N-methyl-D-aspartate receptor antagonists, such as ketamine, can reproduce the negative and affective symptoms of this disorder in animals. Preclinical studies have shown that 5-HT6 receptor (5-HT6R) agonists and antagonists have a considerable antipsychotic response. The aim of the present study was to evaluate the effect of an acute treatment with an agonist, E-6837, and an antagonist, SB-271046, of 5-HT6R on the immobility induced in mice by a subchronic ketamine regimen (5 days; 10 mg/kg/day, intraperitoneal). Repeated ketamine administration alone increased the immobility time in the forced-swimming test and the tail-suspension test. E-6837 at 10 and 20 mg/kg caused a significant reduction of immobility in the tail-suspension test and forced-swimming test, respectively. Interestingly, SB-271046 (10 mg/kg) also elicited an antidepressant-like effect in both tests. The current findings suggest an important role for these 5-HT6R ligands as mood modulators. However, it is necessary to explore the physiological mechanisms involved in this process in greater detail.
@article{suarez-santiago_agonist_2017,
title = {Agonist {E}-6837 and antagonist {SB}-271046 of 5-{HT6} receptors both reverse the depressive-like effect induced in mice by subchronic ketamine administration},
volume = {28},
issn = {1473-5849},
doi = {10.1097/FBP.0000000000000327},
abstract = {Major depression is one of the most common affective disorders caused by schizophrenia. The administration of N-methyl-D-aspartate receptor antagonists, such as ketamine, can reproduce the negative and affective symptoms of this disorder in animals. Preclinical studies have shown that 5-HT6 receptor (5-HT6R) agonists and antagonists have a considerable antipsychotic response. The aim of the present study was to evaluate the effect of an acute treatment with an agonist, E-6837, and an antagonist, SB-271046, of 5-HT6R on the immobility induced in mice by a subchronic ketamine regimen (5 days; 10 mg/kg/day, intraperitoneal). Repeated ketamine administration alone increased the immobility time in the forced-swimming test and the tail-suspension test. E-6837 at 10 and 20 mg/kg caused a significant reduction of immobility in the tail-suspension test and forced-swimming test, respectively. Interestingly, SB-271046 (10 mg/kg) also elicited an antidepressant-like effect in both tests. The current findings suggest an important role for these 5-HT6R ligands as mood modulators. However, it is necessary to explore the physiological mechanisms involved in this process in greater detail.},
language = {eng},
number = {7},
journal = {Behavioural Pharmacology},
author = {Suárez-Santiago, José E. and Briones-Aranda, Alfredo and Espinosa-Raya, Judith and Picazo, Ofir},
month = oct,
year = {2017},
pmid = {28704275},
note = {Number: 7},
keywords = {Animals, Antidepressive Agents, Antipsychotic Agents, Depression, Depressive Disorder, Major, Disease Models, Animal, EXCLUSION MANUELLE FEVRIER 2022, Hindlimb Suspension, Indoles, Ketamine, Male, Mice, Motor Activity, Receptors, N-Methyl-D-Aspartate, Receptors, Serotonin, Schizophrenia, Sulfonamides, Swimming, Thiophenes},
pages = {582--585},
}
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