Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases [Vzaimosviaz' mezhdu dlinoǐ tsepi ékraniruiushchego poli-L-lizina i stepen'iu zashchity poliribonukleotidnykh induktorob interferona ot nukleas krovi cheloveka.]. Surzhik, M., Duks, A., Diatlova, N., Glazunov, E., Feldmane, G., & Timkovskiǐ, A. Antibiotiki i Khimioterapiya, 38(7):21-25, 1993. cited By 1Paper abstract bibtex The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied. The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.
@ARTICLE{Surzhik199321,
author={Surzhik, M.A. and Duks, A.E. and Diatlova, N.G. and Glazunov, E.A. and Feldmane, G.I. and Timkovskiǐ, A.L.},
title={Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases [Vzaimosviaz' mezhdu dlinoǐ tsepi ékraniruiushchego poli-L-lizina i stepen'iu zashchity poliribonukleotidnykh induktorob interferona ot nukleas krovi cheloveka.]},
journal={Antibiotiki i Khimioterapiya},
year={1993},
volume={38},
number={7},
pages={21-25},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027631606&partnerID=40&md5=cd5fd07f76af4766f1ce55f00e95e2fc},
abstract={The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied. The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.},
correspondence_address1={Surzhik, M.A.},
issn={02352990},
pubmed_id={8161271},
language={Russian},
abbrev_source_title={Antibiot Khimioter},
document_type={Article},
source={Scopus},
}
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