@ARTICLE{Surzhik199321,
author={Surzhik, M.A. and Duks, A.E. and Diatlova, N.G. and Glazunov, E.A. and Feldmane, G.I. and Timkovskiǐ, A.L.},
title={Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases [Vzaimosviaz' mezhdu dlinoǐ tsepi ékraniruiushchego poli-L-lizina i stepen'iu zashchity poliribonukleotidnykh induktorob interferona ot nukleas krovi cheloveka.]},
journal={Antibiotiki i Khimioterapiya},
year={1993},
volume={38},
number={7},
pages={21-25},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027631606&partnerID=40&md5=cd5fd07f76af4766f1ce55f00e95e2fc},
abstract={The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied. The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.},
correspondence_address1={Surzhik, M.A.},
issn={02352990},
pubmed_id={8161271},
language={Russian},
abbrev_source_title={Antibiot Khimioter},
document_type={Article},
source={Scopus},
}

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The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.","correspondence_address1":"Surzhik, M.A.","issn":"02352990","pubmed_id":"8161271","language":"Russian","abbrev_source_title":"Antibiot Khimioter","document_type":"Article","source":"Scopus","bibtex":"@ARTICLE{Surzhik199321,\r\nauthor={Surzhik, M.A. and Duks, A.E. and Diatlova, N.G. and Glazunov, E.A. and Feldmane, G.I. and Timkovskiǐ, A.L.},\r\ntitle={Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases [Vzaimosviaz' mezhdu dlinoǐ tsepi ékraniruiushchego poli-L-lizina i stepen'iu zashchity poliribonukleotidnykh induktorob interferona ot nukleas krovi cheloveka.]},\r\njournal={Antibiotiki i Khimioterapiya},\r\nyear={1993},\r\nvolume={38},\r\nnumber={7},\r\npages={21-25},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027631606&partnerID=40&md5=cd5fd07f76af4766f1ce55f00e95e2fc},\r\nabstract={The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied. The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.},\r\ncorrespondence_address1={Surzhik, M.A.},\r\nissn={02352990},\r\npubmed_id={8161271},\r\nlanguage={Russian},\r\nabbrev_source_title={Antibiot Khimioter},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n","author_short":["Surzhik, M.","Duks, A.","Diatlova, N.","Glazunov, E.","Feldmane, G.","Timkovskiǐ, A."],"key":"Surzhik199321","id":"Surzhik199321","bibbaseid":"surzhik-duks-diatlova-glazunov-feldmane-timkovski-interrelationshipbetweenthechainlengthofpolyllysineandthedegreeofprotectionofpolyribonucleotideinterferoninducersfromhumanbloodnucleasesvzaimosviazmezhdudlinotsepikraniruiushchegopolillizinaistepeniuzashchitypoliribonukleotidnykhinduktorobinterferonaotnukleaskrovicheloveka-1993","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027631606&partnerID=40&md5=cd5fd07f76af4766f1ce55f00e95e2fc"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bio.pnpi.nrcki.ru/wp-content/uploads/2019/12/lmkb_2019_10.txt","dataSources":["rgjRz8LhiuL9Prc4S"],"keywords":[],"search_terms":["interrelationship","between","chain","length","poly","lysine","degree","protection","polyribonucleotide","interferon","inducers","human","blood","nucleases","vzaimosviaz","mezhdu","dlino","tsepi","kraniruiushchego","poli","lizina","stepen","zashchity","poliribonukleotidnykh","induktorob","interferona","nukleas","krovi","cheloveka","surzhik","duks","diatlova","glazunov","feldmane","timkovskiǐ"],"title":"Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases [Vzaimosviaz' mezhdu dlinoǐ tsepi ékraniruiushchego poli-L-lizina i stepen'iu zashchity poliribonukleotidnykh induktorob interferona ot nukleas krovi cheloveka.]","year":1993}