Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells. Suzuki, T. & Kamiya, H. Genes and Environment, 39(1):2, dec, 2017. Paper doi abstract bibtex Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been examined in various experimental systems. In this review, we summarize the mutagenicity of the base in mammalian cells. We also describe the effects of specialized DNA polymerases, DNA repair proteins, and nucleotide pool sanitization enzymes.
@article{Suzuki2017,
abstract = {Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been examined in various experimental systems. In this review, we summarize the mutagenicity of the base in mammalian cells. We also describe the effects of specialized DNA polymerases, DNA repair proteins, and nucleotide pool sanitization enzymes.},
author = {Suzuki, Tetsuya and Kamiya, Hiroyuki},
doi = {10.1186/s41021-016-0051-y},
issn = {1880-7062},
journal = {Genes and Environment},
keywords = {8-Hydroxyguanine,8-Oxo-7,8-dihydroguanine,DNA repair protein,Nucleotide pool sanitization enzyme,Specialized DNA polymerase},
month = {dec},
number = {1},
pages = {2},
title = {{Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells}},
url = {https://genesenvironment.biomedcentral.com/articles/10.1186/s41021-016-0051-y},
volume = {39},
year = {2017}
}
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