Influence of electrostatic interactions on cell-penetrating peptide-small interfering RNA complex formation and intracellular delivery efficiency. Svirina, A., Terterov, I., Klimenko, V., Shmakov, S., Knyazev, N., Emelyanov, A., Vysochinskaya, V., & Bogdanov, A. 2018. cited By 0; Conference of 5th International School and Conference on Optoelectronics, Photonics, Engineering and Nanostructures, Saint Petersburg OPEN 2018 ; Conference Date: 2 April 2018 Through 5 April 2018; Conference Code:144220
Influence of electrostatic interactions on cell-penetrating peptide-small interfering RNA complex formation and intracellular delivery efficiency [link]Paper  doi  abstract   bibtex   
Cell-penetrating peptides (CPP) are short positively charged biopolymers that can translocate through lipid membranes. Due to their unique properties CPPs are promising agents for intracellular drug delivery. In this work we studied potency of intracellular delivery of small interfering RNA (siRNA) by means of two CPPs, namely primary amphipathic MPG-ΔNLS peptide and secondary amphipathic EB1 peptide. Optimal concentration conditions and peptide-to-siRNA ratios have been found for stable peptide-siRNA complex formation and delivery efficiency has been shown. © Published under licence by IOP Publishing Ltd.
@CONFERENCE{Svirina2018,
author={Svirina, A. and Terterov, I. and Klimenko, V. and Shmakov, S. and Knyazev, N. and Emelyanov, A. and Vysochinskaya, V. and Bogdanov, A.},
title={Influence of electrostatic interactions on cell-penetrating peptide-small interfering RNA complex formation and intracellular delivery efficiency},
journal={Journal of Physics: Conference Series},
year={2018},
volume={1124},
number={3},
doi={10.1088/1742-6596/1124/3/031005},
art_number={031005},
note={cited By 0; Conference of 5th International School and Conference on Optoelectronics, Photonics, Engineering and Nanostructures, Saint Petersburg OPEN 2018 ; Conference Date: 2 April 2018 Through 5 April 2018;  Conference Code:144220},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060968519&doi=10.1088%2f1742-6596%2f1124%2f3%2f031005&partnerID=40&md5=63b9a460a60a5f2460032ddc4084aa51},
affiliation={Nanobiotech Lab, St. Petersburg Academic University, St.-Petersburg, 194021, Russian Federation; Saint Petersburg Clinical Scientific and Practical Center of Specialized Types of Medical Care, St.-Petersburg, 197758, Russian Federation; Institute of Cytology, RAS, St.-Petersburg, 194064, Russian Federation; Saint Petersburg Nuclear Physics Institute, National Research Center, Kurchatov Institute, Lenoblast, 188300, Russian Federation; Research Institute of Influenza, St.-Petersburg, 197376, Russian Federation; Bionics Lab, ITMO University, St.-Petersburg, 197101, Russian Federation},
abstract={Cell-penetrating peptides (CPP) are short positively charged biopolymers that can translocate through lipid membranes. Due to their unique properties CPPs are promising agents for intracellular drug delivery. In this work we studied potency of intracellular delivery of small interfering RNA (siRNA) by means of two CPPs, namely primary amphipathic MPG-ΔNLS peptide and secondary amphipathic EB1 peptide. Optimal concentration conditions and peptide-to-siRNA ratios have been found for stable peptide-siRNA complex formation and delivery efficiency has been shown. © Published under licence by IOP Publishing Ltd.},
}

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