Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex. Swadlow, H. A., Beloozerova, I. N., & Sirota, M. G. J. Neurophysiology, 79(2):567-82, Feb, 1998. abstract bibtex Many suspected inhibitory interneurons (SINs) of primary somatosensory cortex (S1) receive a potent monosynaptic thalamic input (thalamocortical SINs, SINstc). It has been proposed that nearly all such SINstc of a S1 barrel column (BC) receive excitatory synaptic input from each member of a subpopulation of neurons within the topographically aligned ventrobasal (VB) thalamic barreloid. Such a divergent and convergent network leads to several testable predictions: sharply synchronous activity should occur between SINstc of a BC, sharp synchrony should not occur between SINstc of neighboring BCs, and sharp synchrony should not occur between SINs or other neurons of the same BC that do not receive potent monosynaptic thalamic input. These predictions were tested by cross-correlating the activity of SINstc of the same and neighboring BCs. Correlations among descending corticofugal neurons of layer 5 (CF-5 neurons, identified by antidromic activation) and other neurons that receive little or no monosynaptic VB input also were examined. SINs were identified by a high-frequency (>600 Hz) burst of three or more spikes elicited by VB stimulation and had action potentials of short duration. SINstc were further differentiated by short synaptic latencies to electrical stimulation of VB thalamus (<1.7 ms) and to peripheral stimulation (<7.5 ms). The above predictions were confirmed fully. 1) Sharp synchrony (+/-1 ms) was seen between all SINstc recorded within the same BC (a mean of 4.26% of the spikes of each SINtc were synchronized sharply with the spikes of the paired SINtc). Sharp synchrony was not dependent on peripheral stimulation, was not oscillatory, and survived general anesthesia. Sharp synchrony was superimposed on a broader synchrony, with a time course of tens of milliseconds. 2) Little or no sharp synchrony was seen when CF-5 neurons were paired with SINstc or other neurons of the same BC. 3) Little or no sharp synchrony was seen when SINstc were paired with other SINstc located in neighboring BCs. Intracellular recordings obtained from three SINs in the fully awake state supported the assertion that SINs are GABAergic interneurons. Each of these cells met our extracellular criteria for identification as a SIN, each had a spike of short duration (0.4-0.5 ms), and each responded to a depolarizing current pulse with a nonadapting train of action potentials. These results support the proposed network linking VB barreloid neurons with SINstc within the topographically aligned BC. We suggest that sharp synchrony among SINstc results in highly synchronous inhibitory postsynpatic potentials (IPSPs)in the target neurons of these cells and that these summated IPSPs may be especially effective when excitatory drive to target cells is weak and asynchronous.
@article{ Swadlow_etal98,
author = {Swadlow, H. A. and Beloozerova, I. N. and Sirota, M. G.},
title = {Sharp, local synchrony among putative feed-forward inhibitory interneurons
of rabbit somatosensory cortex},
journal = {J. Neurophysiology},
year = {1998},
volume = {79},
pages = {567-82},
number = {2},
month = {Feb},
abstract = {Many suspected inhibitory interneurons (SINs) of primary somatosensory
cortex (S1) receive a potent monosynaptic thalamic input (thalamocortical
SINs, SINstc). It has been proposed that nearly all such SINstc of
a S1 barrel column (BC) receive excitatory synaptic input from each
member of a subpopulation of neurons within the topographically aligned
ventrobasal (VB) thalamic barreloid. Such a divergent and convergent
network leads to several testable predictions: sharply synchronous
activity should occur between SINstc of a BC, sharp synchrony should
not occur between SINstc of neighboring BCs, and sharp synchrony
should not occur between SINs or other neurons of the same BC that
do not receive potent monosynaptic thalamic input. These predictions
were tested by cross-correlating the activity of SINstc of the same
and neighboring BCs. Correlations among descending corticofugal neurons
of layer 5 (CF-5 neurons, identified by antidromic activation) and
other neurons that receive little or no monosynaptic VB input also
were examined. SINs were identified by a high-frequency (>600 Hz)
burst of three or more spikes elicited by VB stimulation and had
action potentials of short duration. SINstc were further differentiated
by short synaptic latencies to electrical stimulation of VB thalamus
(<1.7 ms) and to peripheral stimulation (<7.5 ms). The above predictions
were confirmed fully. 1) Sharp synchrony (+/-1 ms) was seen between
all SINstc recorded within the same BC (a mean of 4.26% of the spikes
of each SINtc were synchronized sharply with the spikes of the paired
SINtc). Sharp synchrony was not dependent on peripheral stimulation,
was not oscillatory, and survived general anesthesia. Sharp synchrony
was superimposed on a broader synchrony, with a time course of tens
of milliseconds. 2) Little or no sharp synchrony was seen when CF-5
neurons were paired with SINstc or other neurons of the same BC.
3) Little or no sharp synchrony was seen when SINstc were paired
with other SINstc located in neighboring BCs. Intracellular recordings
obtained from three SINs in the fully awake state supported the assertion
that SINs are GABAergic interneurons. Each of these cells met our
extracellular criteria for identification as a SIN, each had a spike
of short duration (0.4-0.5 ms), and each responded to a depolarizing
current pulse with a nonadapting train of action potentials. These
results support the proposed network linking VB barreloid neurons
with SINstc within the topographically aligned BC. We suggest that
sharp synchrony among SINstc results in highly synchronous inhibitory
postsynpatic potentials (IPSPs)in the target neurons of these cells
and that these summated IPSPs may be especially effective when excitatory
drive to target cells is weak and asynchronous.},
en_number = { }
}
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{"_id":"gttd6ZXoZAXc7bDSn","bibbaseid":"swadlow-beloozerova-sirota-sharplocalsynchronyamongputativefeedforwardinhibitoryinterneuronsofrabbitsomatosensorycortex-1998","downloads":0,"creationDate":"2015-02-08T05:14:58.881Z","title":"Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex","author_short":["Swadlow, H.<nbsp>A.","Beloozerova, I.<nbsp>N.","Sirota, M.<nbsp>G."],"year":1998,"bibtype":"article","biburl":"http://cnslab.mb.jhu.edu/niebase.bib","bibdata":{"abstract":"Many suspected inhibitory interneurons (SINs) of primary somatosensory cortex (S1) receive a potent monosynaptic thalamic input (thalamocortical SINs, SINstc). It has been proposed that nearly all such SINstc of a S1 barrel column (BC) receive excitatory synaptic input from each member of a subpopulation of neurons within the topographically aligned ventrobasal (VB) thalamic barreloid. Such a divergent and convergent network leads to several testable predictions: sharply synchronous activity should occur between SINstc of a BC, sharp synchrony should not occur between SINstc of neighboring BCs, and sharp synchrony should not occur between SINs or other neurons of the same BC that do not receive potent monosynaptic thalamic input. These predictions were tested by cross-correlating the activity of SINstc of the same and neighboring BCs. Correlations among descending corticofugal neurons of layer 5 (CF-5 neurons, identified by antidromic activation) and other neurons that receive little or no monosynaptic VB input also were examined. SINs were identified by a high-frequency (>600 Hz) burst of three or more spikes elicited by VB stimulation and had action potentials of short duration. SINstc were further differentiated by short synaptic latencies to electrical stimulation of VB thalamus (<1.7 ms) and to peripheral stimulation (<7.5 ms). The above predictions were confirmed fully. 1) Sharp synchrony (+/-1 ms) was seen between all SINstc recorded within the same BC (a mean of 4.26% of the spikes of each SINtc were synchronized sharply with the spikes of the paired SINtc). Sharp synchrony was not dependent on peripheral stimulation, was not oscillatory, and survived general anesthesia. Sharp synchrony was superimposed on a broader synchrony, with a time course of tens of milliseconds. 2) Little or no sharp synchrony was seen when CF-5 neurons were paired with SINstc or other neurons of the same BC. 3) Little or no sharp synchrony was seen when SINstc were paired with other SINstc located in neighboring BCs. Intracellular recordings obtained from three SINs in the fully awake state supported the assertion that SINs are GABAergic interneurons. Each of these cells met our extracellular criteria for identification as a SIN, each had a spike of short duration (0.4-0.5 ms), and each responded to a depolarizing current pulse with a nonadapting train of action potentials. These results support the proposed network linking VB barreloid neurons with SINstc within the topographically aligned BC. We suggest that sharp synchrony among SINstc results in highly synchronous inhibitory postsynpatic potentials (IPSPs)in the target neurons of these cells and that these summated IPSPs may be especially effective when excitatory drive to target cells is weak and asynchronous.","author":["Swadlow, H. A.","Beloozerova, I. N.","Sirota, M. G."],"author_short":["Swadlow, H.<nbsp>A.","Beloozerova, I.<nbsp>N.","Sirota, M.<nbsp>G."],"bibtex":"@article{ Swadlow_etal98,\n author = {Swadlow, H. A. and Beloozerova, I. N. and Sirota, M. G.},\n title = {Sharp, local synchrony among putative feed-forward inhibitory interneurons\n\tof rabbit somatosensory cortex},\n journal = {J. Neurophysiology},\n year = {1998},\n volume = {79},\n pages = {567-82},\n number = {2},\n month = {Feb},\n abstract = {Many suspected inhibitory interneurons (SINs) of primary somatosensory\n\tcortex (S1) receive a potent monosynaptic thalamic input (thalamocortical\n\tSINs, SINstc). It has been proposed that nearly all such SINstc of\n\ta S1 barrel column (BC) receive excitatory synaptic input from each\n\tmember of a subpopulation of neurons within the topographically aligned\n\tventrobasal (VB) thalamic barreloid. Such a divergent and convergent\n\tnetwork leads to several testable predictions: sharply synchronous\n\tactivity should occur between SINstc of a BC, sharp synchrony should\n\tnot occur between SINstc of neighboring BCs, and sharp synchrony\n\tshould not occur between SINs or other neurons of the same BC that\n\tdo not receive potent monosynaptic thalamic input. These predictions\n\twere tested by cross-correlating the activity of SINstc of the same\n\tand neighboring BCs. Correlations among descending corticofugal neurons\n\tof layer 5 (CF-5 neurons, identified by antidromic activation) and\n\tother neurons that receive little or no monosynaptic VB input also\n\twere examined. SINs were identified by a high-frequency (>600 Hz)\n\tburst of three or more spikes elicited by VB stimulation and had\n\taction potentials of short duration. SINstc were further differentiated\n\tby short synaptic latencies to electrical stimulation of VB thalamus\n\t(<1.7 ms) and to peripheral stimulation (<7.5 ms). The above predictions\n\twere confirmed fully. 1) Sharp synchrony (+/-1 ms) was seen between\n\tall SINstc recorded within the same BC (a mean of 4.26% of the spikes\n\tof each SINtc were synchronized sharply with the spikes of the paired\n\tSINtc). Sharp synchrony was not dependent on peripheral stimulation,\n\twas not oscillatory, and survived general anesthesia. Sharp synchrony\n\twas superimposed on a broader synchrony, with a time course of tens\n\tof milliseconds. 2) Little or no sharp synchrony was seen when CF-5\n\tneurons were paired with SINstc or other neurons of the same BC.\n\t3) Little or no sharp synchrony was seen when SINstc were paired\n\twith other SINstc located in neighboring BCs. Intracellular recordings\n\tobtained from three SINs in the fully awake state supported the assertion\n\tthat SINs are GABAergic interneurons. Each of these cells met our\n\textracellular criteria for identification as a SIN, each had a spike\n\tof short duration (0.4-0.5 ms), and each responded to a depolarizing\n\tcurrent pulse with a nonadapting train of action potentials. These\n\tresults support the proposed network linking VB barreloid neurons\n\twith SINstc within the topographically aligned BC. We suggest that\n\tsharp synchrony among SINstc results in highly synchronous inhibitory\n\tpostsynpatic potentials (IPSPs)in the target neurons of these cells\n\tand that these summated IPSPs may be especially effective when excitatory\n\tdrive to target cells is weak and asynchronous.},\n en_number = { }\n}","bibtype":"article","en_number":"","id":"Swadlow_etal98","journal":"J. 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