Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M. A., Englund, M., Prieto-Alhambra, D., Doherty, M., & Zhang, W. Rheumatology, 60(9):4327–4339, September, 2021. Number: 9![Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex 1 download OBJECTIVE: To determine the burden of comorbidities in osteoarthritis (OA) and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidity (≥2 comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aOR) and hazard ratios (aHR) respectively. RESULTS: During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to, and following, the diagnosis of OA, and 2 (dementia and SLE) were associated with OA only following the diagnosis of OA. People with OA had higher risk of developing heart failure (aHR 1.63; 95% CI 1.56-1.71), dementia (aHR 1.62; 95% CI 1.56-1.68), liver diseases (aHR 1.51; 95% CI 1.37-1.67), irritable bowel syndrome (aHR 1.51; 95% CI 1.45-1.58), gastrointestinal bleeding (aHR 1.49; 95% CI 1.39-1.59), 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95% CI 1.69-1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95% CI 1.28-1.30). CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed.
@article{swain_temporal_2021,
title = {Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the {UK} primary care setting},
volume = {60},
issn = {1462-0332},
shorttitle = {Temporal relationship between osteoarthritis and comorbidities},
url = {https://doi.org/10.1093/rheumatology/keab067},
doi = {10.1093/rheumatology/keab067},
abstract = {OBJECTIVE: To determine the burden of comorbidities in osteoarthritis (OA) and their temporal relationships in the UK.
METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidity (≥2 comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aOR) and hazard ratios (aHR) respectively.
RESULTS: During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to, and following, the diagnosis of OA, and 2 (dementia and SLE) were associated with OA only following the diagnosis of OA. People with OA had higher risk of developing heart failure (aHR 1.63; 95\% CI 1.56-1.71), dementia (aHR 1.62; 95\% CI 1.56-1.68), liver diseases (aHR 1.51; 95\% CI 1.37-1.67), irritable bowel syndrome (aHR 1.51; 95\% CI 1.45-1.58), gastrointestinal bleeding (aHR 1.49; 95\% CI 1.39-1.59), 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95\% CI 1.69-1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95\% CI 1.28-1.30).
CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed.},
language = {eng},
number = {9},
journal = {Rheumatology},
author = {Swain, Subhashisa and Coupland, Carol and Mallen, Christian and Kuo, Chang Fu and Sarmanova, Aliya and Bierma-Zeinstra, Sita M. A. and Englund, Martin and Prieto-Alhambra, Daniel and Doherty, Michael and Zhang, Weiya},
month = sep,
year = {2021},
pmid = {33506862},
note = {Number: 9},
keywords = {Osteoarthritis, burden, comorbidity, multimorbidity, temporal association},
pages = {4327--4339},
}
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METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidity (≥2 comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aOR) and hazard ratios (aHR) respectively. RESULTS: During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to, and following, the diagnosis of OA, and 2 (dementia and SLE) were associated with OA only following the diagnosis of OA. People with OA had higher risk of developing heart failure (aHR 1.63; 95% CI 1.56-1.71), dementia (aHR 1.62; 95% CI 1.56-1.68), liver diseases (aHR 1.51; 95% CI 1.37-1.67), irritable bowel syndrome (aHR 1.51; 95% CI 1.45-1.58), gastrointestinal bleeding (aHR 1.49; 95% CI 1.39-1.59), 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95% CI 1.69-1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95% CI 1.28-1.30). CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed.","language":"eng","number":"9","journal":"Rheumatology","author":[{"propositions":[],"lastnames":["Swain"],"firstnames":["Subhashisa"],"suffixes":[]},{"propositions":[],"lastnames":["Coupland"],"firstnames":["Carol"],"suffixes":[]},{"propositions":[],"lastnames":["Mallen"],"firstnames":["Christian"],"suffixes":[]},{"propositions":[],"lastnames":["Kuo"],"firstnames":["Chang","Fu"],"suffixes":[]},{"propositions":[],"lastnames":["Sarmanova"],"firstnames":["Aliya"],"suffixes":[]},{"propositions":[],"lastnames":["Bierma-Zeinstra"],"firstnames":["Sita","M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Prieto-Alhambra"],"firstnames":["Daniel"],"suffixes":[]},{"propositions":[],"lastnames":["Doherty"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Weiya"],"suffixes":[]}],"month":"September","year":"2021","pmid":"33506862","note":"Number: 9","keywords":"Osteoarthritis, burden, comorbidity, multimorbidity, temporal association","pages":"4327–4339","bibtex":"@article{swain_temporal_2021,\n\ttitle = {Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the {UK} primary care setting},\n\tvolume = {60},\n\tissn = {1462-0332},\n\tshorttitle = {Temporal relationship between osteoarthritis and comorbidities},\n\turl = {https://doi.org/10.1093/rheumatology/keab067},\n\tdoi = {10.1093/rheumatology/keab067},\n\tabstract = {OBJECTIVE: To determine the burden of comorbidities in osteoarthritis (OA) and their temporal relationships in the UK.\nMETHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidity (≥2 comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aOR) and hazard ratios (aHR) respectively.\nRESULTS: During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to, and following, the diagnosis of OA, and 2 (dementia and SLE) were associated with OA only following the diagnosis of OA. People with OA had higher risk of developing heart failure (aHR 1.63; 95\\% CI 1.56-1.71), dementia (aHR 1.62; 95\\% CI 1.56-1.68), liver diseases (aHR 1.51; 95\\% CI 1.37-1.67), irritable bowel syndrome (aHR 1.51; 95\\% CI 1.45-1.58), gastrointestinal bleeding (aHR 1.49; 95\\% CI 1.39-1.59), 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95\\% CI 1.69-1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95\\% CI 1.28-1.30).\nCONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Rheumatology},\n\tauthor = {Swain, Subhashisa and Coupland, Carol and Mallen, Christian and Kuo, Chang Fu and Sarmanova, Aliya and Bierma-Zeinstra, Sita M. A. and Englund, Martin and Prieto-Alhambra, Daniel and Doherty, Michael and Zhang, Weiya},\n\tmonth = sep,\n\tyear = {2021},\n\tpmid = {33506862},\n\tnote = {Number: 9},\n\tkeywords = {Osteoarthritis, burden, comorbidity, multimorbidity, temporal association},\n\tpages = {4327--4339},\n}\n\n","author_short":["Swain, S.","Coupland, C.","Mallen, C.","Kuo, C. F.","Sarmanova, A.","Bierma-Zeinstra, S. M. 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