Artificial Selection for Increased Wheel-Running Behavior in House Mice. Swallow, J. G., Carter, P. A., & Garland, T. Behavior Genetics, 28(3):227--237. Paper doi abstract bibtex Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent–offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12–0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.
@article{swallow_artificial_????,
title = {Artificial {Selection} for {Increased} {Wheel}-{Running} {Behavior} in {House} {Mice}},
volume = {28},
issn = {0001-8244, 1573-3297},
url = {http://link.springer.com/article/10.1023/A:1021479331779},
doi = {10.1023/A:1021479331779},
abstract = {Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent–offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75\% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12–0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.},
language = {en},
number = {3},
urldate = {2016-08-17TZ},
journal = {Behavior Genetics},
author = {Swallow, John G. and Carter, Patrick A. and Garland, Theodore},
pages = {227--237}
}
Downloads: 0
{"_id":"HjfnopvKyD3cgxr6t","bibbaseid":"swallow-carter-garland-artificialselectionforincreasedwheelrunningbehaviorinhousemice","downloads":0,"creationDate":"2016-08-17T22:12:13.913Z","title":"Artificial Selection for Increased Wheel-Running Behavior in House Mice","author_short":["Swallow, J. G.","Carter, P. A.","Garland, T."],"year":null,"bibtype":"article","biburl":"https://api.zotero.org/users/2223311/collections/HMQ7E9D3/items?key=51NpCawlXbfdfyVBeJXzOm9P&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Artificial Selection for Increased Wheel-Running Behavior in House Mice","volume":"28","issn":"0001-8244, 1573-3297","url":"http://link.springer.com/article/10.1023/A:1021479331779","doi":"10.1023/A:1021479331779","abstract":"Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent–offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12–0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.","language":"en","number":"3","urldate":"2016-08-17TZ","journal":"Behavior Genetics","author":[{"propositions":[],"lastnames":["Swallow"],"firstnames":["John","G."],"suffixes":[]},{"propositions":[],"lastnames":["Carter"],"firstnames":["Patrick","A."],"suffixes":[]},{"propositions":[],"lastnames":["Garland"],"firstnames":["Theodore"],"suffixes":[]}],"pages":"227--237","bibtex":"@article{swallow_artificial_????,\n\ttitle = {Artificial {Selection} for {Increased} {Wheel}-{Running} {Behavior} in {House} {Mice}},\n\tvolume = {28},\n\tissn = {0001-8244, 1573-3297},\n\turl = {http://link.springer.com/article/10.1023/A:1021479331779},\n\tdoi = {10.1023/A:1021479331779},\n\tabstract = {Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent–offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75\\% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12–0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.},\n\tlanguage = {en},\n\tnumber = {3},\n\turldate = {2016-08-17TZ},\n\tjournal = {Behavior Genetics},\n\tauthor = {Swallow, John G. and Carter, Patrick A. and Garland, Theodore},\n\tpages = {227--237}\n}\n\n","author_short":["Swallow, J. G.","Carter, P. A.","Garland, T."],"key":"swallow_artificial_????","id":"swallow_artificial_????","bibbaseid":"swallow-carter-garland-artificialselectionforincreasedwheelrunningbehaviorinhousemice","role":"author","urls":{"Paper":"http://link.springer.com/article/10.1023/A:1021479331779"},"downloads":0},"search_terms":["artificial","selection","increased","wheel","running","behavior","house","mice","swallow","carter","garland"],"keywords":[],"authorIDs":[],"dataSources":["YQYy7k3SxcvHpM74L"]}