Artificial selection for increased wheel-running behavior in house mice. Swallow, J. G., Carter, P. A., & Garland, T. Behavior Genetics, 28(3):227--237, May, 1998. abstract bibtex Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.
@article{swallow_artificial_1998,
title = {Artificial selection for increased wheel-running behavior in house mice},
volume = {28},
issn = {0001-8244},
abstract = {Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75\% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.},
language = {eng},
number = {3},
journal = {Behavior Genetics},
author = {Swallow, J. G. and Carter, P. A. and Garland, T.},
month = may,
year = {1998},
pmid = {9670598},
keywords = {Analysis of Variance, Animals, Crosses, Genetic, Female, Male, Mice, Mice, Inbred ICR, Motor Activity, Regression Analysis, Selection, Genetic},
pages = {227--237}
}
Downloads: 0
{"_id":"KLSEWowJ8wtveenKq","bibbaseid":"swallow-carter-garland-artificialselectionforincreasedwheelrunningbehaviorinhousemice-1998","downloads":0,"creationDate":"2016-08-17T22:23:35.891Z","title":"Artificial selection for increased wheel-running behavior in house mice","author_short":["Swallow, J. G.","Carter, P. A.","Garland, T."],"year":1998,"bibtype":"article","biburl":"https://api.zotero.org/users/2223311/collections/HMQ7E9D3/items?key=51NpCawlXbfdfyVBeJXzOm9P&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Artificial selection for increased wheel-running behavior in house mice","volume":"28","issn":"0001-8244","abstract":"Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.","language":"eng","number":"3","journal":"Behavior Genetics","author":[{"propositions":[],"lastnames":["Swallow"],"firstnames":["J.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Carter"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Garland"],"firstnames":["T."],"suffixes":[]}],"month":"May","year":"1998","pmid":"9670598","keywords":"Analysis of Variance, Animals, Crosses, Genetic, Female, Male, Mice, Mice, Inbred ICR, Motor Activity, Regression Analysis, Selection, Genetic","pages":"227--237","bibtex":"@article{swallow_artificial_1998,\n\ttitle = {Artificial selection for increased wheel-running behavior in house mice},\n\tvolume = {28},\n\tissn = {0001-8244},\n\tabstract = {Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75\\% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Behavior Genetics},\n\tauthor = {Swallow, J. G. and Carter, P. A. and Garland, T.},\n\tmonth = may,\n\tyear = {1998},\n\tpmid = {9670598},\n\tkeywords = {Analysis of Variance, Animals, Crosses, Genetic, Female, Male, Mice, Mice, Inbred ICR, Motor Activity, Regression Analysis, Selection, Genetic},\n\tpages = {227--237}\n}\n\n","author_short":["Swallow, J. G.","Carter, P. A.","Garland, T."],"key":"swallow_artificial_1998","id":"swallow_artificial_1998","bibbaseid":"swallow-carter-garland-artificialselectionforincreasedwheelrunningbehaviorinhousemice-1998","role":"author","urls":{},"keyword":["Analysis of Variance","Animals","Crosses","Genetic","Female","Male","Mice","Mice","Inbred ICR","Motor Activity","Regression Analysis","Selection","Genetic"],"downloads":0},"search_terms":["artificial","selection","increased","wheel","running","behavior","house","mice","swallow","carter","garland"],"keywords":["analysis of variance","animals","crosses","genetic","female","male","mice","mice","inbred icr","motor activity","regression analysis","selection","genetic"],"authorIDs":[],"dataSources":["YQYy7k3SxcvHpM74L"]}