Artificial selection for increased wheel-running behavior in house mice. Swallow, J. G., Carter, P. A., & Garland, T. Behavior Genetics, 28(3):227--237, May, 1998.
abstract   bibtex   
Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.
@article{swallow_artificial_1998,
	title = {Artificial selection for increased wheel-running behavior in house mice},
	volume = {28},
	issn = {0001-8244},
	abstract = {Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of minutes during which any activity occurred (min/day) were estimated by midparent-offspring regression. Heritabilities were 0.18, 0.28, and 0.14, respectively; the estimate for min/day did not differ significantly from zero. Ten generations of selection for increased rev/day resulted in an average 75\% increase in activity in the four selected lines, as compared with control lines. Realized heritability averaged 0.19 (range, 0.12-0.24 for the high-activity lines), or 0.28 when adjusted for within-family selection. Rev/day increased mainly through changes in rpm rather than min/day. These lines will be studied for correlated responses in exercise physiology capacities and will be made available to other researchers on request.},
	language = {eng},
	number = {3},
	journal = {Behavior Genetics},
	author = {Swallow, J. G. and Carter, P. A. and Garland, T.},
	month = may,
	year = {1998},
	pmid = {9670598},
	keywords = {Analysis of Variance, Animals, Crosses, Genetic, Female, Male, Mice, Mice, Inbred ICR, Motor Activity, Regression Analysis, Selection, Genetic},
	pages = {227--237}
}

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