Discontinuous Galerkin Model of Cellular Electroporation. Sweeney, D. C. & Davalos, R. V. Annu Int Conf IEEE Eng Med Biol Soc, 2018:5850-5853, 2018. 2694-0604 Sweeney, Daniel C Davalos, Rafael V R01 CA213423/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. United States 2018/11/18 Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5850-5853. doi: 10.1109/EMBC.2018.8513541.doi abstract bibtex Electroporation (EP) is a phenomenon involving both nonlinear biophysical processes and complex geometries. When exposed to strong electric fields, the formation of pores within a cell membrane increases the membrane permeability. Discontinuous Galerkin (DG) finite element methods can directly enforce these flux jumps across the thin cell membrane interface. We implement a DG finite element method to model the electric field, pore formation, and transmembrane flux of charged solutes during EP. Our model is readily extensible for parallel computation on high performance clusters and agrees with previous reports.
@article{RN151,
author = {Sweeney, D. C. and Davalos, R. V.},
title = {Discontinuous Galerkin Model of Cellular Electroporation},
journal = {Annu Int Conf IEEE Eng Med Biol Soc},
volume = {2018},
pages = {5850-5853},
note = {2694-0604
Sweeney, Daniel C
Davalos, Rafael V
R01 CA213423/CA/NCI NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
United States
2018/11/18
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5850-5853. doi: 10.1109/EMBC.2018.8513541.},
abstract = {Electroporation (EP) is a phenomenon involving both nonlinear biophysical processes and complex geometries. When exposed to strong electric fields, the formation of pores within a cell membrane increases the membrane permeability. Discontinuous Galerkin (DG) finite element methods can directly enforce these flux jumps across the thin cell membrane interface. We implement a DG finite element method to model the electric field, pore formation, and transmembrane flux of charged solutes during EP. Our model is readily extensible for parallel computation on high performance clusters and agrees with previous reports.},
keywords = {Cell Membrane/physiology
*Cell Membrane Permeability
*Electroporation
Finite Element Analysis
Models, Biological},
ISSN = {2375-7477},
DOI = {10.1109/embc.2018.8513541},
year = {2018},
type = {Journal Article}
}
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