Are Ecstasy Induced Serotonergic Alterations Overestimated For The Majority Of Users ?. Szigeti, B., Winstock, A., R., Erritzoe, D., & Maier, L., J. Journal of Psychopharmacology, SAGE PublicationsSage UK: London, England, 5, 2018.
Are Ecstasy Induced Serotonergic Alterations Overestimated For The Majority Of Users ? [link]Website  abstract   bibtex   
Background:Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain’s serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users.Aims:We examined the representativeness of ecstasy users enrolled in neuroimaging studies by comparing their ecstasy use habits with the use patterns of a large, international sample.Methods:A systematic literature search revealed 10 imaging studies that compare serotonin transporter levels in recreational ecstasy users to matched controls. To characterize the ecstasy use patterns we relied on the Global Drug Survey, the world’s largest self-report database on drug use. The basis of the dose comparison were the Usual Amount (pills/session), Use Frequency (sessions/month) and Dose Intensity (pills/year) variables.Results:Both the average Usual Amount (pills/session...
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 title = {Are Ecstasy Induced Serotonergic Alterations Overestimated For The Majority Of Users ?},
 type = {article},
 year = {2018},
 identifiers = {[object Object]},
 keywords = {drug policy,ecstasy,epidemiology,mdma},
 pages = {026988111876764},
 websites = {http://journals.sagepub.com/doi/10.1177/0269881118767646},
 month = {5},
 publisher = {SAGE PublicationsSage UK: London, England},
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 abstract = {Background:Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain’s serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users.Aims:We examined the representativeness of ecstasy users enrolled in neuroimaging studies by comparing their ecstasy use habits with the use patterns of a large, international sample.Methods:A systematic literature search revealed 10 imaging studies that compare serotonin transporter levels in recreational ecstasy users to matched controls. To characterize the ecstasy use patterns we relied on the Global Drug Survey, the world’s largest self-report database on drug use. The basis of the dose comparison were the Usual Amount (pills/session), Use Frequency (sessions/month) and Dose Intensity (pills/year) variables.Results:Both the average Usual Amount (pills/session...},
 bibtype = {article},
 author = {Szigeti, Balázs and Winstock, Adam R. and Erritzoe, David and Maier, Larissa J},
 journal = {Journal of Psychopharmacology}
}

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