Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Ta, T. A.; Koenig, C. M; Golub, M. S; Pessah, I. N; Qi, L.; Aronov, P. A; and Berman, R. F Neurotoxicology and teratology, 33(3):393--404.
Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. [link]Paper  doi  abstract   bibtex   
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that have become pervasive environmental contaminants and may contribute to adverse health outcomes. We evaluated in mice the developmental neurotoxicity of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), one of the most abundant PBDE congeners detected in animal and human tissues. Female C57BL/6J mice were exposed to daily doses of 0, 0.03, 0.1 or 1mg/kg beginning 4 weeks prior to conception, continuing through gestation and lactation, and ending at weaning on postnatal day (PND) 21. Levels of BDE-47 in blood, brain, liver and adipose tissues of dams were markedly increased after 4 weeks of exposure, around the time of mating, and continued to increase through the time of parturition. Blood levels of BDE-47 in the dosed dams were within the range reported in humans. BDE-47 tissue levels in the dams decreased between parturition and weaning, possibly reflecting mobilization during lactation. Brain BDE-47 levels in the offspring at PND 1 approached those of the dams at parturition. Perinatal exposure to BDE-47 resulted in significant dose dependent growth retardation, slower motor performance in several behavioral tests, and mice exposed to 1mg/kg/day BDE-47 showed altered performance in the Morris water maze. There were no differences between groups in the numbers of pyramidal neurons in hippocampus CA1. These results document accumulation of BDE-47 in several organ systems following exposure to low-levels of BDE-47, and provide evidence that such exposure is associated with early behavioral deficits in exposed neonates.
@article{ta_bioaccumulation_nodate,
	title = {Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether ({BDE}-47) in perinatally exposed mice.},
	volume = {33},
	issn = {1872-9738},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3543834&tool=pmcentrez&rendertype=abstract},
	doi = {10.1016/j.ntt.2011.02.003},
	abstract = {Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that have become pervasive environmental contaminants and may contribute to adverse health outcomes. We evaluated in mice the developmental neurotoxicity of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), one of the most abundant PBDE congeners detected in animal and human tissues. Female C57BL/6J mice were exposed to daily doses of 0, 0.03, 0.1 or 1mg/kg beginning 4 weeks prior to conception, continuing through gestation and lactation, and ending at weaning on postnatal day (PND) 21. Levels of BDE-47 in blood, brain, liver and adipose tissues of dams were markedly increased after 4 weeks of exposure, around the time of mating, and continued to increase through the time of parturition. Blood levels of BDE-47 in the dosed dams were within the range reported in humans. BDE-47 tissue levels in the dams decreased between parturition and weaning, possibly reflecting mobilization during lactation. Brain BDE-47 levels in the offspring at PND 1 approached those of the dams at parturition. Perinatal exposure to BDE-47 resulted in significant dose dependent growth retardation, slower motor performance in several behavioral tests, and mice exposed to 1mg/kg/day BDE-47 showed altered performance in the Morris water maze. There were no differences between groups in the numbers of pyramidal neurons in hippocampus CA1. These results document accumulation of BDE-47 in several organ systems following exposure to low-levels of BDE-47, and provide evidence that such exposure is associated with early behavioral deficits in exposed neonates.},
	number = {3},
	journal = {Neurotoxicology and teratology},
	author = {Ta, Tram Anh and Koenig, Claire M and Golub, Mari S and Pessah, Isaac N and Qi, Lihong and Aronov, Pavel A and Berman, Robert F},
	pmid = {21334437},
	keywords = {Animal, Animal: drug effects, Animals, Behavior, CA1 Region, Cell Count, Dose-Response Relationship, Drug, Environmental Pollutants, Environmental Pollutants: pharmacokinetics, Environmental Pollutants: toxicity, Female, Flame retardants, Gas Chromatography-Mass Spectrometry, Gestational Age, Hippocampal, Hippocampal: drug effects, Hippocampal: embryology, Hippocampal: growth \& development, Inbred C57BL, Male, Maternal Exposure, Maternal Exposure: adverse effects, Maze Learning, Maze Learning: drug effects, Mice, Motor Activity, Motor Activity: drug effects, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacokinetics, Polybrominated Biphenyls: toxicity, Pregnancy, Prenatal Exposure Delayed Effects, Prenatal Exposure Delayed Effects: chemically indu, Prenatal Exposure Delayed Effects: metabolism, Prenatal Exposure Delayed Effects: pathology, Prenatal Exposure Delayed Effects: psychology, Pyramidal Cells, Pyramidal Cells: drug effects, Pyramidal Cells: metabolism, Pyramidal Cells: pathology, Tissue Distribution, Weaning},
	pages = {393--404}
}
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