@article{tajik_association_2025,
	title = {Association between injury-related factors and cartilage {T2} relaxation time in the subacute phase in patients after anterior cruciate ligament injury},
	volume = {33},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2025.05.002},
	abstract = {OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.
DESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs was determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage were performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL-injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest.
RESULTS: There was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95\% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading.
CONCLUSION: In the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.},
	language = {eng},
	number = {8},
	journal = {Osteoarthritis and Cartilage},
	author = {Tajik, Bashir Edwardsson and Kvist, Joanna and Gauffin, Håkan and Cristiani, Riccardo and Frobell, Richard and Nieminen, Miika and Casula, Victor and Englund, Martin},
	month = aug,
	year = {2025},
	keywords = {Adolescent, Adult, Anterior Cruciate Ligament Injuries, Anterior cruciate ligament, Bone Marrow, Cartilage, Cartilage, Articular, Female, Humans, Knee, Magnetic Resonance Imaging, Magnetic resonance imaging, Male, Menisci, Middle Aged, Tibial, Tibial Meniscus Injuries, Weight-Bearing, Young Adult},
	pages = {1033--1040},
}

{"_id":"Mijp97Rcjw7njXvzQ","bibbaseid":"tajik-kvist-gauffin-cristiani-frobell-nieminen-casula-englund-associationbetweeninjuryrelatedfactorsandcartilaget2relaxationtimeinthesubacutephaseinpatientsafteranteriorcruciateligamentinjury-2025","author_short":["Tajik, B. E.","Kvist, J.","Gauffin, H.","Cristiani, R.","Frobell, R.","Nieminen, M.","Casula, V.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"Association between injury-related factors and cartilage T2 relaxation time in the subacute phase in patients after anterior cruciate ligament injury","volume":"33","issn":"1522-9653","doi":"10.1016/j.joca.2025.05.002","abstract":"OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury. DESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs was determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage were performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL-injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest. RESULTS: There was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading. CONCLUSION: In the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.","language":"eng","number":"8","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Tajik"],"firstnames":["Bashir","Edwardsson"],"suffixes":[]},{"propositions":[],"lastnames":["Kvist"],"firstnames":["Joanna"],"suffixes":[]},{"propositions":[],"lastnames":["Gauffin"],"firstnames":["Håkan"],"suffixes":[]},{"propositions":[],"lastnames":["Cristiani"],"firstnames":["Riccardo"],"suffixes":[]},{"propositions":[],"lastnames":["Frobell"],"firstnames":["Richard"],"suffixes":[]},{"propositions":[],"lastnames":["Nieminen"],"firstnames":["Miika"],"suffixes":[]},{"propositions":[],"lastnames":["Casula"],"firstnames":["Victor"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]}],"month":"August","year":"2025","keywords":"Adolescent, Adult, Anterior Cruciate Ligament Injuries, Anterior cruciate ligament, Bone Marrow, Cartilage, Cartilage, Articular, Female, Humans, Knee, Magnetic Resonance Imaging, Magnetic resonance imaging, Male, Menisci, Middle Aged, Tibial, Tibial Meniscus Injuries, Weight-Bearing, Young Adult","pages":"1033–1040","bibtex":"@article{tajik_association_2025,\n\ttitle = {Association between injury-related factors and cartilage {T2} relaxation time in the subacute phase in patients after anterior cruciate ligament injury},\n\tvolume = {33},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2025.05.002},\n\tabstract = {OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.\nDESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs was determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage were performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL-injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest.\nRESULTS: There was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95\\% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading.\nCONCLUSION: In the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Tajik, Bashir Edwardsson and Kvist, Joanna and Gauffin, Håkan and Cristiani, Riccardo and Frobell, Richard and Nieminen, Miika and Casula, Victor and Englund, Martin},\n\tmonth = aug,\n\tyear = {2025},\n\tkeywords = {Adolescent, Adult, Anterior Cruciate Ligament Injuries, Anterior cruciate ligament, Bone Marrow, Cartilage, Cartilage, Articular, Female, Humans, Knee, Magnetic Resonance Imaging, Magnetic resonance imaging, Male, Menisci, Middle Aged, Tibial, Tibial Meniscus Injuries, Weight-Bearing, Young Adult},\n\tpages = {1033--1040},\n}\n\n","author_short":["Tajik, B. E.","Kvist, J.","Gauffin, H.","Cristiani, R.","Frobell, R.","Nieminen, M.","Casula, V.","Englund, M."],"key":"tajik_association_2025","id":"tajik_association_2025","bibbaseid":"tajik-kvist-gauffin-cristiani-frobell-nieminen-casula-englund-associationbetweeninjuryrelatedfactorsandcartilaget2relaxationtimeinthesubacutephaseinpatientsafteranteriorcruciateligamentinjury-2025","role":"author","urls":{},"keyword":["Adolescent","Adult","Anterior Cruciate Ligament Injuries","Anterior cruciate ligament","Bone Marrow","Cartilage","Cartilage","Articular","Female","Humans","Knee","Magnetic Resonance Imaging","Magnetic resonance imaging","Male","Menisci","Middle Aged","Tibial","Tibial Meniscus Injuries","Weight-Bearing","Young Adult"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["LPTeGao77ndnG4Tks"],"keywords":["adolescent","adult","anterior cruciate ligament injuries","anterior cruciate ligament","bone marrow","cartilage","cartilage","articular","female","humans","knee","magnetic resonance imaging","magnetic resonance imaging","male","menisci","middle aged","tibial","tibial meniscus injuries","weight-bearing","young adult"],"search_terms":["association","between","injury","related","factors","cartilage","relaxation","time","subacute","phase","patients","anterior","cruciate","ligament","injury","tajik","kvist","gauffin","cristiani","frobell","nieminen","casula","englund"],"title":"Association between injury-related factors and cartilage T2 relaxation time in the subacute phase in patients after anterior cruciate ligament injury","year":2025}