Parental ADHD Status and its Association with Proband ADHD Subtype and Severity. Takeda, T.; Stotesbery, K.; Power, T.; Ambrosini, P., J.; Berrettini, W.; Hakonarson, H.; and Elia, J. Journal of Pediatrics, 157(6):995-U191.
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Objective To better understand the familial transmission of attention deficit hyperactivity disorder (ADHD), a highly heritable disorder, the effects of paternal and maternal ADHD status on probands' ADHD symptoms and subtypes were investigated. Study design In 323 trios with ADHD, data from a structured interview and a self-report scale (score of >21) were used to determine ADHD probands' diagnostic status and parental ADHD status, respectively. Parental ADHD status on proband ADHD severity and subtypes was investigated. Results ADHD criteria were endorsed by 23% of fathers and 27% of mothers, and by at least one parent in 41% of the cases. ADHD severity was higher for children whose parents had ADHD versus those whose parents were without it. Paternal ADHD was associated with an increased likelihood of ADHD combined subtype (odds ratio = 3.56) and a decreased likelihood of the inattentive subtype (odds ratio = 0.34) in male children. Conclusions Parental ADHD status appears to confer different risks for the severity of hyperactive-impulsive and inattentive symptoms depending on parental sex; however, parental ADHD self-report scale score has low to negligible correlation with proband's ADHD severity. Biparental ADHD does not appear to have an additive or synergistic effect on the proband's ADHD severity. (J Pediatr 2010;157:995-1000).
@article{
 title = {Parental ADHD Status and its Association with Proband ADHD Subtype and Severity},
 type = {article},
 keywords = {ATTENTION-DEFICIT/HYPERACTIVITY,CHILDHOOD,CHILDREN,COMORBIDITY,DEFICIT HYPERACTIVITY DISORDER,DISORDER,FAMILY,GENERAL-POPULATION,GIRLS,REPORT SCALE ASRS,TWIN},
 pages = {995-U191},
 volume = {157},
 websites = {<Go to ISI>://WOS:000284307200030},
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 created = {2012-01-16T22:01:45.000Z},
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 last_modified = {2017-03-14T17:04:22.077Z},
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 source_type = {Journal Article},
 language = {English},
 notes = {ISI Document Delivery No.: 681JG<m:linebreak></m:linebreak>Times Cited: 0<m:linebreak></m:linebreak>Cited Reference Count: 30<m:linebreak></m:linebreak>Takeda, Toshinobu Stotesbery, Kory Power, Thomas Ambrosini, Paul J. Berrettini, Wade Hakonarson, Hakon Elia, Josephine<m:linebreak></m:linebreak>MOSBY-ELSEVIER},
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 abstract = {Objective To better understand the familial transmission of attention deficit hyperactivity disorder (ADHD), a highly heritable disorder, the effects of paternal and maternal ADHD status on probands' ADHD symptoms and subtypes were investigated. Study design In 323 trios with ADHD, data from a structured interview and a self-report scale (score of >21) were used to determine ADHD probands' diagnostic status and parental ADHD status, respectively. Parental ADHD status on proband ADHD severity and subtypes was investigated. Results ADHD criteria were endorsed by 23% of fathers and 27% of mothers, and by at least one parent in 41% of the cases. ADHD severity was higher for children whose parents had ADHD versus those whose parents were without it. Paternal ADHD was associated with an increased likelihood of ADHD combined subtype (odds ratio = 3.56) and a decreased likelihood of the inattentive subtype (odds ratio = 0.34) in male children. Conclusions Parental ADHD status appears to confer different risks for the severity of hyperactive-impulsive and inattentive symptoms depending on parental sex; however, parental ADHD self-report scale score has low to negligible correlation with proband's ADHD severity. Biparental ADHD does not appear to have an additive or synergistic effect on the proband's ADHD severity. (J Pediatr 2010;157:995-1000).},
 bibtype = {article},
 author = {Takeda, T and Stotesbery, K and Power, T and Ambrosini, P J and Berrettini, W and Hakonarson, H and Elia, J},
 journal = {Journal of Pediatrics},
 number = {6}
}
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