@Article{takats04mass,
  author    = {Zolt{\'a}n Tak{\'a}ts and Justin M Wiseman and Bogdan Gologan and R. Graham Cooks},
  title     = {Mass spectrometry sampling under ambient conditions with desorption electrospray ionization},
  journal   = {Science},
  year      = {2004},
  volume    = {306},
  number    = {5695},
  pages     = {471--473},
  abstract  = {A new method of desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing electrosprayed charged droplets and ions of solvent onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.},
  doi       = {10.1126/science.1104404},
  optmonth  = oct,
  owner     = {fhufsky},
  pmid      = {15486296},
  timestamp = {2011.06.28},
}

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