Synthesis, DNA-binding and photocleavage studies of [Ru(phen)2(pbtp)]2+ and [Ru(bpy)2(pbtp)]2+ (phen=1,10-phenanthroline; bpy=2,2'-bipyridine; pbtp=4,5,9,11,14-pentaaza-benzo[b]triphenylene). Tan, L., Xiao, Y., Liu, X., & Zhang, S. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 73(5):858–64, September, 2009.
Paper doi abstract bibtex Based on the ligand dppz (dppz=dipyrido-[3,2-a:2',3'-c]phenazine), a new ligand pbtp (pbtp=4,5,9,11,14-pentaaza-benzo[b]triphenylene) and its polypyridyl ruthenium(II) complexes [Ru(phen)(2)(pbtp)](2+) (1) (phen=1,10-phenanthroline and [Ru(bpy)(2)(pbtp)](2+) (2) (bpy=2,2'-bipyridine) have been synthesized and characterized by elemental analysis, ES-MS and (1)H NMR spectroscopy. The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that both complexes 1 and 2 bind to CT-DNA in classical intercalation mode, and can enantioselectively interact with CT-DNA. It is interesting to note that the pbtp ruthenium(II) complexes, in contrast to the analogous dppz complexes, do not show fluorescent behavior when intercalated into DNA. When irradiated at 365 nm, both complexes promote the photocleavage of pBR 322 DNA.
@article{Tan2009,
title = {Synthesis, {DNA}-binding and photocleavage studies of [{Ru}(phen)2(pbtp)]2+ and [{Ru}(bpy)2(pbtp)]2+ (phen=1,10-phenanthroline; bpy=2,2'-bipyridine; pbtp=4,5,9,11,14-pentaaza-benzo[b]triphenylene).},
volume = {73},
issn = {1873-3557},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19497781},
doi = {10.1016/j.saa.2009.04.021},
abstract = {Based on the ligand dppz (dppz=dipyrido-[3,2-a:2',3'-c]phenazine), a new ligand pbtp (pbtp=4,5,9,11,14-pentaaza-benzo[b]triphenylene) and its polypyridyl ruthenium(II) complexes [Ru(phen)(2)(pbtp)](2+) (1) (phen=1,10-phenanthroline and [Ru(bpy)(2)(pbtp)](2+) (2) (bpy=2,2'-bipyridine) have been synthesized and characterized by elemental analysis, ES-MS and (1)H NMR spectroscopy. The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that both complexes 1 and 2 bind to CT-DNA in classical intercalation mode, and can enantioselectively interact with CT-DNA. It is interesting to note that the pbtp ruthenium(II) complexes, in contrast to the analogous dppz complexes, do not show fluorescent behavior when intercalated into DNA. When irradiated at 365 nm, both complexes promote the photocleavage of pBR 322 DNA.},
number = {5},
journal = {Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
author = {Tan, Lifeng and Xiao, Yue and Liu, Xiaohua and Zhang, Sheng},
month = sep,
year = {2009},
pmid = {19497781},
keywords = {\#nosource, Animals, Binding, Binding Sites, Cattle, Competitive, DNA, DNA: metabolism, Intercalating Agents, Intercalating Agents: chemical synthesis, Intercalating Agents: chemistry, Intercalating Agents: pharmacology, Ligands, Molecular Structure, Nucleic Acid Conformation, Organometallic Compounds, Organometallic Compounds: chemical synthesis, Organometallic Compounds: chemistry, Organometallic Compounds: pharmacology, Photochemical Processes, Temperature, Viscosity},
pages = {858--64},
}
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