Saturation of postsynaptic receptors after quantal release of transmitter. Tang, C. M., Margulis, M., Shi, Q. Y., & Fielding, A. Neuron, 13(6):1385-1393, 1994.
abstract   bibtex   
Miniature excitatory postsynaptic currents (mEPSCs) were elicited from small numbers of release sites after brief microperfusion of Ba2+ and K+ onto proximal dendritic processes of hippocampal neurons in culture. Temporal summation of closely timed mEPSCs deviated significantly from linearity. The number of instances of closely timed mEPSCs that were also closely matched in terms of peak amplitudes was significantly greater than that expected by chance. Amplitude pairing became statistically more significant after prolongation of mEPSC duration and inhibition of glutamate receptor desensitization with cyclothiazide. These results are best explained by postsynaptic receptors that approach saturation after quantal release of transmitter.
@article{ Tang_etal94,
  author = {Tang, C. M. and Margulis, M. and Shi, Q. Y. and Fielding, A.},
  title = {Saturation of postsynaptic receptors after quantal release of transmitter},
  journal = {Neuron},
  year = {1994},
  volume = {13},
  pages = {1385-1393},
  number = {6},
  abstract = { Miniature excitatory postsynaptic currents (mEPSCs) were elicited
	from small numbers of release sites after brief microperfusion of
	Ba2+ and K+ onto proximal dendritic processes of hippocampal neurons
	in culture. Temporal summation of closely timed mEPSCs deviated significantly
	from linearity. The number of instances of closely timed mEPSCs that
	were also closely matched in terms of peak amplitudes was significantly
	greater than that expected by chance. Amplitude pairing became statistically
	more significant after prolongation of mEPSC duration and inhibition
	of glutamate receptor desensitization with cyclothiazide. These results
	are best explained by postsynaptic receptors that approach saturation
	after quantal release of transmitter.},
  en_number = { }
}

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