@article{Tanner2019,
abstract = {Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both drug-susceptible and drug-resistant strains of Mtb. We determined the in vitro anti-Mtb activities; absorption, distribution, metabolism, and excretion properties; and in vivo mouse pharmacokinetics of a series of structurally related phenoxazines. One of these, PhX1, displayed promising drug-like properties and potent in vitro efficacy, supporting its further investigation in an Mtb-infected animal model.},
author = {Tanner, Lloyd and Evans, Joanna C and Seldon, Ronnett and Jordaan, Audrey and Warner, Digby F and Haynes, Richard K and Parkinson, Christopher J and Wiesner, Lubbe},
doi = {10.1128/AAC.01010-19},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Tanner et al. - 2019 - iIn vitroi efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against iMycobacter.pdf:pdf},
journal = {Antimicrobial Agents and Chemotherapy},
keywords = {fund{\_}not{\_}ack,original},
mendeley-tags = {fund{\_}not{\_}ack,original},
month = {aug},
pages = {e01010--19},
pmid = {31427302},
publisher = {American Society for Microbiology Journals},
title = {{\textit{In vitro} efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against \textit{Mycobacterium tuberculosis}}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/31427302},
volume = {63},
year = {2019}
}

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