Drift of tetM determinant in urogenital microbiocenosis containing mycoplasmas during treatment with a tetracycline antibiotic. Taraskina, A., Savicheva, A., Akopian, T., Soroka, A., Momynaliev, K., & Govorun, V. Bulletin of Experimental Biology and Medicine, 134(1):60-63, 2002. cited By 5
Drift of tetM determinant in urogenital microbiocenosis containing mycoplasmas during treatment with a tetracycline antibiotic [link]Paper  doi  abstract   bibtex   
We studied the correlation between genetic transfer of tetM determinant in Tn916 conjugative transposon by urogenital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and changes in the bacterial repertoire during treatment with a tetracycline antibiotic. Basic conditions favoring the nonspecific transfer of tetM determinant into mollicute cells are determined and the allele polymorphism of tetM determinant in clinical strains of M. hominis and U. urealyticum is evaluated. The structure of tetM gene in clinical mycoplasma and ureaplasma strains s characterized by a peculiar mosaic pattern and differs from all previously described alleles of this gene. The results suggest that tetracycline resistance in mollicutes is determined by mechanisms alternative to genetic transfer of tetM determinant.
@ARTICLE{Taraskina200260,
author={Taraskina, A.E. and Savicheva, A.M. and Akopian, T.A. and Soroka, A.E. and Momynaliev, K.T. and Govorun, V.M.},
title={Drift of tetM determinant in urogenital microbiocenosis containing mycoplasmas during treatment with a tetracycline antibiotic},
journal={Bulletin of Experimental Biology and Medicine},
year={2002},
volume={134},
number={1},
pages={60-63},
doi={10.1023/A:1020664807029},
note={cited By 5},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036665010&doi=10.1023%2fA%3a1020664807029&partnerID=40&md5=d43744d4353aed2be0f8505ce216e5bc},
affiliation={Laboratory of Microbiology, D.O. Ott Inst. of Obstet./Gynecol., Russian Academy of Medical Sciences, St. Petersburg, Russian Federation; Lab. of Gene Eng. and Immunogenet., Institute of Physicochem. Medicine, Ministry of Health of Russian Fed., Moscow, Russian Federation},
abstract={We studied the correlation between genetic transfer of tetM determinant in Tn916 conjugative transposon by urogenital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and changes in the bacterial repertoire during treatment with a tetracycline antibiotic. Basic conditions favoring the nonspecific transfer of tetM determinant into mollicute cells are determined and the allele polymorphism of tetM determinant in clinical strains of M. hominis and U. urealyticum is evaluated. The structure of tetM gene in clinical mycoplasma and ureaplasma strains s characterized by a peculiar mosaic pattern and differs from all previously described alleles of this gene. The results suggest that tetracycline resistance in mollicutes is determined by mechanisms alternative to genetic transfer of tetM determinant.},
author_keywords={Allele polymorphism;  Antibiotic resistance;  Mycoplasma hominis;  tetM determinant;  Ureaplasma urealyticum},
correspondence_address1={Taraskina, A.E.; Laboratory of Microbiology, D.O. Ott Inst. of Obstet./Gynecol., Russian Academy of Medical Sciences, St. Petersburg, Russian Federation},
issn={00074888},
coden={BEXBA},
pubmed_id={12459871},
language={English},
abbrev_source_title={Bull. Exp. Biol. Med.},
document_type={Article},
source={Scopus},
}

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