Impact and Spreading of a Compound Droplet: A Model for Single Cell Epitaxi. Tasoglu, S., Kaynak, G., & Muradoglu, M. 62:BH.007, November, 2009. Conference Name: APS Division of Fluid Dynamics Meeting Abstracts ADS Bibcode: 2009APS..DFD.BH007TPaper abstract bibtex In recent years, there has been a growing interest in generating compound droplets mainly due to their potential commercial value [1] and applications in emerging technologies such as single cell epitaxi [2]. Ejecting encapsulated cells on a rigid surface is a promising way to produce 2D/3D tissues [2]. However, this gained experimental capability requires a true understanding of the impact dynamics of the encapsulated cells on solid surfaces for further development. In the present study, a finite-volume/front-tracking method is used to model the impact and spreading of a viscous compound droplet on a flat solid surface as a first step in developing a model for the single cell epitaxi. The cell, the encapsulating droplet and ambient fluid are all assumed to be Newtonian. Simulations are performed for a range of dimensionless parameters and their effects on deformation of inner droplet are investigated. These results provide initial insight about the optimum parameter ranges for highest viability of cells. [1] Utada, Lorenceau, Link, et al., Science, 308(5721), (2005). [2] Demirci and Montesano, Lab Chip, 7, (2007).
@article{tasoglu_impact_2009,
title = {Impact and {Spreading} of a {Compound} {Droplet}: {A} {Model} for {Single} {Cell} {Epitaxi}},
volume = {62},
shorttitle = {Impact and {Spreading} of a {Compound} {Droplet}},
url = {https://ui.adsabs.harvard.edu/abs/2009APS..DFD.BH007T},
abstract = {In recent years, there has been a growing interest in generating compound droplets mainly due to their potential commercial value [1] and applications in emerging technologies such as single cell epitaxi [2]. Ejecting encapsulated cells on a rigid surface is a promising way to produce 2D/3D tissues [2]. However, this gained experimental capability requires a true understanding of the impact dynamics of the encapsulated cells on solid surfaces for further development. In the present study, a finite-volume/front-tracking method is used to model the impact and spreading of a viscous compound droplet on a flat solid surface as a first step in developing a model for the single cell epitaxi. The cell, the encapsulating droplet and ambient fluid are all assumed to be Newtonian. Simulations are performed for a range of dimensionless parameters and their effects on deformation of inner droplet are investigated. These results provide initial insight about the optimum parameter ranges for highest viability of cells. [1] Utada, Lorenceau, Link, et al., Science, 308(5721), (2005). [2] Demirci and Montesano, Lab Chip, 7, (2007).},
urldate = {2023-09-29},
author = {Tasoglu, Savas and Kaynak, Gozde and Muradoglu, Metin},
month = nov,
year = {2009},
note = {Conference Name: APS Division of Fluid Dynamics Meeting Abstracts
ADS Bibcode: 2009APS..DFD.BH007T},
pages = {BH.007},
}
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