The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam. Taylor, W. R., Nguyen, K., Nguyen, D., Nguyen, H., Horby, P., Nguyen, H. L., Lien, T., Tran, G., Tran, N., Nguyen, H. M., Nguyen, T., Nguyen, H. H., Nguyen, T., Tran, G., Farrar, J., de Jong, M., Schultsz, C., Tran, H., Nguyen, D., Vu, B., Le, H., Dao, T., Nguyen, T., & Wertheim, H. PloS one, 7(8):e42099, 2012. doi abstract bibtex OBJECTIVES: To determine prospectively the causative pathogens of central nervous system (CNS) infections in patients admitted to a tertiary referral hospital in Hanoi, Vietnam. METHODS: From May 2007 to December 2008, cerebrospinal fluid (CSF) samples from 352 adults with suspected meningitis or encephalitis underwent routine testing, staining (Gram, Ziehl-Nielsen, India ink), bacterial culture and polymerase chain reaction targeting Neisseria meningitidis, Streptococcus pneumoniae, S. suis, Haemophilus influenzae type b, Herpes simplex virus (HSV), Varicella Zoster virus (VZV), enterovirus, and 16S ribosomal RNA. Blood cultures and clinically indicated radiology were also performed. Patients were classified as having confirmed or suspected bacterial (BM), tuberculous (TBM), cryptococcal (CRM), eosinophilic (EOM) meningitis, aseptic encephalitis/meningitis (AEM), neurocysticercosis and others. RESULTS: 352 (male: 66%) patients were recruited: median age 34 years (range 13-85). 95/352 (27.3%) diagnoses were laboratory confirmed and one by cranial radiology: BM (n = 62), TBM (n = 9), AEM (n = 19), CRM (n = 5), and neurocysticercosis (n = 1, cranial radiology). S. suis predominated as the cause of BM [48/62 (77.4%)]; Listeria monocytogenese (n = 1), S. pasteurianus (n = 1) and N. meningitidis (n = 2) were infrequent. AEM viruses were: HSV (n = 12), VZV (n = 5) and enterovirus (n = 2). 5 patients had EOM. Of 262/352 (74.4%) patients with full clinical data, 209 (79.8%) were hospital referrals and 186 (71%) had been on antimicrobials. 21 (8%) patients died: TBM (15.2%), AEM (10%), and BM (2.8%). CONCLUSIONS: Most infections lacked microbiological confirmation. S. suis was the most common cause of BM in this setting. Improved diagnostics are needed for meningoencephalitic syndromes to inform treatment and prevention strategies.
@article{taylor_spectrum_2012,
title = {The spectrum of central nervous system infections in an adult referral hospital in {Hanoi}, {Vietnam}.},
volume = {7},
issn = {1932-6203 1932-6203},
doi = {10.1371/journal.pone.0042099},
abstract = {OBJECTIVES: To determine prospectively the causative pathogens of central nervous system (CNS) infections in patients admitted to a tertiary referral hospital in Hanoi, Vietnam. METHODS: From May 2007 to December 2008, cerebrospinal fluid (CSF) samples from 352 adults with suspected meningitis or encephalitis underwent routine testing, staining (Gram, Ziehl-Nielsen, India ink), bacterial culture and polymerase chain reaction targeting Neisseria meningitidis, Streptococcus pneumoniae, S. suis, Haemophilus influenzae type b, Herpes simplex virus (HSV), Varicella Zoster virus (VZV), enterovirus, and 16S ribosomal RNA. Blood cultures and clinically indicated radiology were also performed. Patients were classified as having confirmed or suspected bacterial (BM), tuberculous (TBM), cryptococcal (CRM), eosinophilic (EOM) meningitis, aseptic encephalitis/meningitis (AEM), neurocysticercosis and others. RESULTS: 352 (male: 66\%) patients were recruited: median age 34 years (range 13-85). 95/352 (27.3\%) diagnoses were laboratory confirmed and one by cranial radiology: BM (n = 62), TBM (n = 9), AEM (n = 19), CRM (n = 5), and neurocysticercosis (n = 1, cranial radiology). S. suis predominated as the cause of BM [48/62 (77.4\%)]; Listeria monocytogenese (n = 1), S. pasteurianus (n = 1) and N. meningitidis (n = 2) were infrequent. AEM viruses were: HSV (n = 12), VZV (n = 5) and enterovirus (n = 2). 5 patients had EOM. Of 262/352 (74.4\%) patients with full clinical data, 209 (79.8\%) were hospital referrals and 186 (71\%) had been on antimicrobials. 21 (8\%) patients died: TBM (15.2\%), AEM (10\%), and BM (2.8\%). CONCLUSIONS: Most infections lacked microbiological confirmation. S. suis was the most common cause of BM in this setting. Improved diagnostics are needed for meningoencephalitic syndromes to inform treatment and prevention strategies.},
language = {eng},
number = {8},
journal = {PloS one},
author = {Taylor, Walter R. and Nguyen, Kinh and Nguyen, Duc and Nguyen, Huyen and Horby, Peter and Nguyen, Ha L. and Lien, Trinh and Tran, Giang and Tran, Ninh and Nguyen, Ha M. and Nguyen, Thai and Nguyen, Ha H. and Nguyen, Thanh and Tran, Giap and Farrar, Jeremy and de Jong, Menno and Schultsz, Constance and Tran, Huong and Nguyen, Diep and Vu, Bich and Le, Hoa and Dao, Trinh and Nguyen, Trung and Wertheim, Heiman},
year = {2012},
pmid = {22952590},
pmcid = {PMC3431395},
keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Central Nervous System Infections/cerebrospinal fluid/*epidemiology/*microbiology, Encephalitis/cerebrospinal fluid/*epidemiology/*microbiology, Female, Humans, Male, Meningitis/cerebrospinal fluid/*epidemiology/*microbiology, Middle Aged, Polymerase Chain Reaction/methods, Prospective Studies, Referral and Consultation, Streptococcus suis/*metabolism, Treatment Outcome, Vietnam},
pages = {e42099},
}
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{"_id":"FxH6xTdTCyQPctW4B","bibbaseid":"taylor-nguyen-nguyen-nguyen-horby-nguyen-lien-tran-etal-thespectrumofcentralnervoussysteminfectionsinanadultreferralhospitalinhanoivietnam-2012","downloads":0,"creationDate":"2017-08-31T14:54:27.898Z","title":"The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam.","author_short":["Taylor, W. R.","Nguyen, K.","Nguyen, D.","Nguyen, H.","Horby, P.","Nguyen, H. L.","Lien, T.","Tran, G.","Tran, N.","Nguyen, H. M.","Nguyen, T.","Nguyen, H. H.","Nguyen, T.","Tran, G.","Farrar, J.","de Jong, M.","Schultsz, C.","Tran, H.","Nguyen, D.","Vu, B.","Le, H.","Dao, T.","Nguyen, T.","Wertheim, H."],"year":2012,"bibtype":"article","biburl":"https://api.zotero.org/users/4242995/collections/GEVPECXU/items?key=zD4uWY4xk1YOLS3UQ7bLDMqH&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam.","volume":"7","issn":"1932-6203 1932-6203","doi":"10.1371/journal.pone.0042099","abstract":"OBJECTIVES: To determine prospectively the causative pathogens of central nervous system (CNS) infections in patients admitted to a tertiary referral hospital in Hanoi, Vietnam. METHODS: From May 2007 to December 2008, cerebrospinal fluid (CSF) samples from 352 adults with suspected meningitis or encephalitis underwent routine testing, staining (Gram, Ziehl-Nielsen, India ink), bacterial culture and polymerase chain reaction targeting Neisseria meningitidis, Streptococcus pneumoniae, S. suis, Haemophilus influenzae type b, Herpes simplex virus (HSV), Varicella Zoster virus (VZV), enterovirus, and 16S ribosomal RNA. Blood cultures and clinically indicated radiology were also performed. Patients were classified as having confirmed or suspected bacterial (BM), tuberculous (TBM), cryptococcal (CRM), eosinophilic (EOM) meningitis, aseptic encephalitis/meningitis (AEM), neurocysticercosis and others. RESULTS: 352 (male: 66%) patients were recruited: median age 34 years (range 13-85). 95/352 (27.3%) diagnoses were laboratory confirmed and one by cranial radiology: BM (n = 62), TBM (n = 9), AEM (n = 19), CRM (n = 5), and neurocysticercosis (n = 1, cranial radiology). S. suis predominated as the cause of BM [48/62 (77.4%)]; Listeria monocytogenese (n = 1), S. pasteurianus (n = 1) and N. meningitidis (n = 2) were infrequent. AEM viruses were: HSV (n = 12), VZV (n = 5) and enterovirus (n = 2). 5 patients had EOM. Of 262/352 (74.4%) patients with full clinical data, 209 (79.8%) were hospital referrals and 186 (71%) had been on antimicrobials. 21 (8%) patients died: TBM (15.2%), AEM (10%), and BM (2.8%). CONCLUSIONS: Most infections lacked microbiological confirmation. S. suis was the most common cause of BM in this setting. Improved diagnostics are needed for meningoencephalitic syndromes to inform treatment and prevention strategies.","language":"eng","number":"8","journal":"PloS one","author":[{"propositions":[],"lastnames":["Taylor"],"firstnames":["Walter","R."],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Kinh"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Duc"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Huyen"],"suffixes":[]},{"propositions":[],"lastnames":["Horby"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Ha","L."],"suffixes":[]},{"propositions":[],"lastnames":["Lien"],"firstnames":["Trinh"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Giang"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Ninh"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Ha","M."],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Thai"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Ha","H."],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Thanh"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Giap"],"suffixes":[]},{"propositions":[],"lastnames":["Farrar"],"firstnames":["Jeremy"],"suffixes":[]},{"propositions":["de"],"lastnames":["Jong"],"firstnames":["Menno"],"suffixes":[]},{"propositions":[],"lastnames":["Schultsz"],"firstnames":["Constance"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Huong"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Diep"],"suffixes":[]},{"propositions":[],"lastnames":["Vu"],"firstnames":["Bich"],"suffixes":[]},{"propositions":[],"lastnames":["Le"],"firstnames":["Hoa"],"suffixes":[]},{"propositions":[],"lastnames":["Dao"],"firstnames":["Trinh"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Trung"],"suffixes":[]},{"propositions":[],"lastnames":["Wertheim"],"firstnames":["Heiman"],"suffixes":[]}],"year":"2012","pmid":"22952590","pmcid":"PMC3431395","keywords":"Adolescent, Adult, Aged, Aged, 80 and over, Central Nervous System Infections/cerebrospinal fluid/*epidemiology/*microbiology, Encephalitis/cerebrospinal fluid/*epidemiology/*microbiology, Female, Humans, Male, Meningitis/cerebrospinal fluid/*epidemiology/*microbiology, Middle Aged, Polymerase Chain Reaction/methods, Prospective Studies, Referral and Consultation, Streptococcus suis/*metabolism, Treatment Outcome, Vietnam","pages":"e42099","bibtex":"@article{taylor_spectrum_2012,\n\ttitle = {The spectrum of central nervous system infections in an adult referral hospital in {Hanoi}, {Vietnam}.},\n\tvolume = {7},\n\tissn = {1932-6203 1932-6203},\n\tdoi = {10.1371/journal.pone.0042099},\n\tabstract = {OBJECTIVES: To determine prospectively the causative pathogens of central nervous system (CNS) infections in patients admitted to a tertiary referral hospital in Hanoi, Vietnam. METHODS: From May 2007 to December 2008, cerebrospinal fluid (CSF) samples from 352 adults with suspected meningitis or encephalitis underwent routine testing, staining (Gram, Ziehl-Nielsen, India ink), bacterial culture and polymerase chain reaction targeting Neisseria meningitidis, Streptococcus pneumoniae, S. suis, Haemophilus influenzae type b, Herpes simplex virus (HSV), Varicella Zoster virus (VZV), enterovirus, and 16S ribosomal RNA. Blood cultures and clinically indicated radiology were also performed. Patients were classified as having confirmed or suspected bacterial (BM), tuberculous (TBM), cryptococcal (CRM), eosinophilic (EOM) meningitis, aseptic encephalitis/meningitis (AEM), neurocysticercosis and others. 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Improved diagnostics are needed for meningoencephalitic syndromes to inform treatment and prevention strategies.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {PloS one},\n\tauthor = {Taylor, Walter R. and Nguyen, Kinh and Nguyen, Duc and Nguyen, Huyen and Horby, Peter and Nguyen, Ha L. and Lien, Trinh and Tran, Giang and Tran, Ninh and Nguyen, Ha M. and Nguyen, Thai and Nguyen, Ha H. and Nguyen, Thanh and Tran, Giap and Farrar, Jeremy and de Jong, Menno and Schultsz, Constance and Tran, Huong and Nguyen, Diep and Vu, Bich and Le, Hoa and Dao, Trinh and Nguyen, Trung and Wertheim, Heiman},\n\tyear = {2012},\n\tpmid = {22952590},\n\tpmcid = {PMC3431395},\n\tkeywords = {Adolescent, Adult, Aged, Aged, 80 and over, Central Nervous System Infections/cerebrospinal fluid/*epidemiology/*microbiology, Encephalitis/cerebrospinal fluid/*epidemiology/*microbiology, Female, Humans, Male, Meningitis/cerebrospinal fluid/*epidemiology/*microbiology, Middle Aged, Polymerase Chain Reaction/methods, Prospective Studies, Referral and Consultation, Streptococcus suis/*metabolism, Treatment Outcome, Vietnam},\n\tpages = {e42099},\n}\n\n","author_short":["Taylor, W. 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