Synthesis of a potent g-quadruplex-binding macrocyclic heptaoxazole. Tera, M., Iida, K., Ishizuka, H., Takagi, M., Suganuma, M., Doi, T., Shin-ya, K., Nagasawa, K., & Keisuke Iida Masayuki Tera Hiromichi Ishizuka, M. T. ChemBioChem, 10(3):431–435 ST – Synthesis of a Potent G–Quadruplex–B, March, 2009. tex.ids= teraSynthesisPotentGQuadruplexBinding2009 tex.city: Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), 2-24-16 Nakamachi, Koganei Tokyo 184-8588 (Japan), Fax: (+81) 42-388-7295; Biomedicinal Information Research Center (BIRC), Japan B![Synthesis of a potent g-quadruplex-binding macrocyclic heptaoxazole [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex A novel G-quadruplex binder, L1H1-7OTD (shown in color by atom type), was developed. This macrocyclic heptaoxazole potently and selectively stabilizes telomeric DNA in an intramolecular antiparallel G-quadruplex conformation. L1H1-7OTD shows selective cytotoxicity toward HeLa cells, a telomerase-positive cell line.
@article{Tera2009,
title = {Synthesis of a potent g-quadruplex-binding macrocyclic heptaoxazole},
volume = {10},
issn = {1439-7633},
url = {http://dx.doi.org/10.1002/cbic.200800563 http://www.ncbi.nlm.nih.gov/pubmed/19140143},
doi = {10.1002/cbic.200800563},
abstract = {A novel G-quadruplex binder, L1H1-7OTD (shown in color by atom type), was developed. This macrocyclic heptaoxazole potently and selectively stabilizes telomeric DNA in an intramolecular antiparallel G-quadruplex conformation. L1H1-7OTD shows selective cytotoxicity toward HeLa cells, a telomerase-positive cell line.},
number = {3},
journal = {ChemBioChem},
author = {Tera, Masayuki and Iida, Keisuke and Ishizuka, Hiromichi and Takagi, Motoki and Suganuma, Masami and Doi, Takayuki and Shin-ya, Kazuo and Nagasawa, Kazuo and Keisuke Iida Masayuki Tera Hiromichi Ishizuka, Motoki Takagi, Takayuki Doi, Kazuo Shin-ya, Kazuo Nagasawa, C1 - 10.1002/cbic.200800563, Masami Suganuma},
month = mar,
year = {2009},
pmid = {19140143},
note = {tex.ids= teraSynthesisPotentGQuadruplexBinding2009
tex.city: Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), 2-24-16 Nakamachi, Koganei Tokyo 184-8588 (Japan), Fax: (+81) 42-388-7295; Biomedicinal Information Research Center (BIRC), Japan B},
keywords = {\#nosource, Animals, Cell Line, G-Quadruplexes, Humans, Macrocyclic Compounds, Macrocyclic Compounds: chemical synthesis, Macrocyclic Compounds: chemistry, Models, Molecular, Molecular Structure, Nucleic Acid Conformation, Oxazoles, Oxazoles: chemical synthesis, Oxazoles: chemistry, Telomere, Telomere: chemistry, Telomere: genetics},
pages = {431--435 ST -- Synthesis of a Potent G--Quadruplex--B},
}
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