@article{terracciano_poly2-oxazoline-based_2024,
	title = {Poly(2-oxazoline)-{Based} {Thermoresponsive} {Stomatocytes}},
	volume = {25},
	issn = {1525-7797},
	doi = {10.1021/acs.biomac.4c00726},
	abstract = {The design of biocompatible and biodegradable nanostructures with controlled morphological features remains a predominant challenge in medical research. Stimuli-responsive vesicles offer significant advantages in drug delivery, biomedical applications, and diagnostic techniques. The combination of poly(2-oxazoline)s with biodegradable polymers could provide exceptional biocompatibility properties and be proposed as a versatile platform for the development of new medicines. Therefore, poly(2-ethyl-2-oxazoline) (PEtOx) and poly(2-isopropyl-2-oxazoline) (PiPrOx) possessing a hydroxy terminal group that acts as an initiator for the ring-opening polymerization of d,l-lactide (DLLA) have been utilized in this study. The resulting amphiphilic block polymers were used to create polymersomes, which undergo solvent-dependent reorganization into bowl-shaped vesicles or stomatocytes. By blending PEtOx-b-PDLLA and PiPrOx-b-PDLLA copolymers, a thermoresponsive stomatocyte was generated, where the opening narrowed and irreversibly closed with a slight increase in the temperature. Detailed transmission electron microscopy analysis reveals the formation of both closed and fused stomatocytes upon heating the sample above the critical solution temperature of PiPrOx.},
	number = {9},
	urldate = {2024-08-21},
	journal = {BIOMACROMOLECULES},
	author = {Terracciano, Roberto and Liu, Yuechi and Varanaraja, Zivani and Godzina, Magdalena and Yilmaz, Gokhan and van Hest, Jan C. M. and Becer, C. Remzi},
	month = aug,
	year = {2024},
	pages = {6050--6059},
}

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Therefore, poly(2-ethyl-2-oxazoline) (PEtOx) and poly(2-isopropyl-2-oxazoline) (PiPrOx) possessing a hydroxy terminal group that acts as an initiator for the ring-opening polymerization of d,l-lactide (DLLA) have been utilized in this study. The resulting amphiphilic block polymers were used to create polymersomes, which undergo solvent-dependent reorganization into bowl-shaped vesicles or stomatocytes. By blending PEtOx-b-PDLLA and PiPrOx-b-PDLLA copolymers, a thermoresponsive stomatocyte was generated, where the opening narrowed and irreversibly closed with a slight increase in the temperature. Detailed transmission electron microscopy analysis reveals the formation of both closed and fused stomatocytes upon heating the sample above the critical solution temperature of PiPrOx.","number":"9","urldate":"2024-08-21","journal":"BIOMACROMOLECULES","author":[{"propositions":[],"lastnames":["Terracciano"],"firstnames":["Roberto"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Yuechi"],"suffixes":[]},{"propositions":[],"lastnames":["Varanaraja"],"firstnames":["Zivani"],"suffixes":[]},{"propositions":[],"lastnames":["Godzina"],"firstnames":["Magdalena"],"suffixes":[]},{"propositions":[],"lastnames":["Yilmaz"],"firstnames":["Gokhan"],"suffixes":[]},{"propositions":["van"],"lastnames":["Hest"],"firstnames":["Jan","C.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Becer"],"firstnames":["C.","Remzi"],"suffixes":[]}],"month":"August","year":"2024","pages":"6050–6059","bibtex":"@article{terracciano_poly2-oxazoline-based_2024,\n\ttitle = {Poly(2-oxazoline)-{Based} {Thermoresponsive} {Stomatocytes}},\n\tvolume = {25},\n\tissn = {1525-7797},\n\tdoi = {10.1021/acs.biomac.4c00726},\n\tabstract = {The design of biocompatible and biodegradable nanostructures with controlled morphological features remains a predominant challenge in medical research. Stimuli-responsive vesicles offer significant advantages in drug delivery, biomedical applications, and diagnostic techniques. The combination of poly(2-oxazoline)s with biodegradable polymers could provide exceptional biocompatibility properties and be proposed as a versatile platform for the development of new medicines. Therefore, poly(2-ethyl-2-oxazoline) (PEtOx) and poly(2-isopropyl-2-oxazoline) (PiPrOx) possessing a hydroxy terminal group that acts as an initiator for the ring-opening polymerization of d,l-lactide (DLLA) have been utilized in this study. The resulting amphiphilic block polymers were used to create polymersomes, which undergo solvent-dependent reorganization into bowl-shaped vesicles or stomatocytes. By blending PEtOx-b-PDLLA and PiPrOx-b-PDLLA copolymers, a thermoresponsive stomatocyte was generated, where the opening narrowed and irreversibly closed with a slight increase in the temperature. Detailed transmission electron microscopy analysis reveals the formation of both closed and fused stomatocytes upon heating the sample above the critical solution temperature of PiPrOx.},\n\tnumber = {9},\n\turldate = {2024-08-21},\n\tjournal = {BIOMACROMOLECULES},\n\tauthor = {Terracciano, Roberto and Liu, Yuechi and Varanaraja, Zivani and Godzina, Magdalena and Yilmaz, Gokhan and van Hest, Jan C. M. and Becer, C. Remzi},\n\tmonth = aug,\n\tyear = {2024},\n\tpages = {6050--6059},\n}\n\n","author_short":["Terracciano, R.","Liu, Y.","Varanaraja, Z.","Godzina, M.","Yilmaz, G.","van Hest, J. C. M.","Becer, C. R."],"key":"terracciano_poly2-oxazoline-based_2024","id":"terracciano_poly2-oxazoline-based_2024","bibbaseid":"terracciano-liu-varanaraja-godzina-yilmaz-vanhest-becer-poly2oxazolinebasedthermoresponsivestomatocytes-2024","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://warwick.ac.uk/fac/cross_fac/wesic/research/wpg/research/WPGsep2024.bib","dataSources":["m4fxWT6XKrYfGbZFR","GBhqMC9hjyD5vqptk","6idaYK6okJY39mWgG"],"keywords":[],"search_terms":["poly","oxazoline","based","thermoresponsive","stomatocytes","terracciano","liu","varanaraja","godzina","yilmaz","van hest","becer"],"title":"Poly(2-oxazoline)-Based Thermoresponsive Stomatocytes","year":2024}