Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Thinnes, C., C., Tumber, A., Yapp, C., Scozzafava, G., Yeh, T., Chan, M., C., Tran, T., A., Hsu, K., Tarhonskaya, H., Walport, L., J., Wilkins, S., E., Martinez, E., D., Müller, S., Pugh, C., W., Ratcliffe, P., J., Brennan, P., E., Kawamura, A., & Schofield, C., J. Chemical Communications, 51(84):15458-15461, 10, 2015.
doi abstract bibtex

A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including for KDM4 demethylases.

@article{
 title = {Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases},
 type = {article},
 year = {2015},
 keywords = {Dose-Response Relationship, Drug,Enzyme Inhibitors,Humans,Models, Molecular,Molecular Structure,Oxygenases,Oxyquinoline,Structure-Activity Relationship},
 pages = {15458-15461},
 volume = {51},
 month = {10},
 id = {e7c7f15e-5771-35ef-8f90-77b1e826cc93},
 created = {2016-12-01T10:12:01.000Z},
 file_attached = {false},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-07-09T12:39:49.660Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Thinnes2015},
 source_type = {JOUR},
 private_publication = {false},
 abstract = {<p>A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including for KDM4 demethylases.</p>},
 bibtype = {article},
 author = {Thinnes, C. C. and Tumber, A. and Yapp, C. and Scozzafava, G. and Yeh, T. and Chan, M. C. and Tran, T. A. and Hsu, K. and Tarhonskaya, H. and Walport, L. J. and Wilkins, S. E. and Martinez, E. D. and Müller, S. and Pugh, C. W. and Ratcliffe, P. J. and Brennan, P. E. and Kawamura, A. and Schofield, C. J.},
 doi = {10.1039/c5cc06095h},
 journal = {Chemical Communications},
 number = {84}
}

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