A simulation of the magnetic resonance elastography steady state wave response through idealised atherosclerotic plaques. Thomas-Seale, L‥., Klatt, D., Pankaj, P., Roberts, N., Sack, I., & Hoskins, P‥ IAENG International Journal of Computer Science, 38(4):394-400, 2011. cited By (since 1996)1
A simulation of the magnetic resonance elastography steady state wave response through idealised atherosclerotic plaques [link]Paper  abstract   bibtex   
The clinical assessment of the rupture risk of atherosclerotic plaque is made by imaging the reduction of the lumen; via ultrasound or angiography. It is known that this is an imperfect criterion and that other characteristics of the plaque, such as the change in mechanical properties, may be more relevant. Magnetic Resonance Elastography (MRE) is a novel imaging technique that measures tissue stiffness. Magnetic resonance imaging measures the tissue displacement in response to harmonic shear waves excited on the surface of the body by a vibrating actuator. The images of wave propagation are transformed into an image of stiffness using an inversion algorithm. A steady state analysis was conducted on a simulation of MRE shear waves propagating through an idealised atherosclerotic plaque. The variation of the 2D complex wave response was investigated with regards to stenosis size, lipid pool size and excitation frequency. The detectability of small lipid pools was shown to increase with frequency. However significant wave disruptions were observed at higher excitation frequencies. This study shall form the basis for future work on incorporating an inversion algorithm into the simulation.
@article{ Thomas-Seale2011394,
  author = {Thomas-Seale, L.E.J.a  and Klatt, D.b  and Pankaj, P.c  and Roberts, N.d  and Sack, I.b  and Hoskins, P.R.a },
  title = {A simulation of the magnetic resonance elastography steady state wave response through idealised atherosclerotic plaques},
  journal = {IAENG International Journal of Computer Science},
  year = {2011},
  volume = {38},
  number = {4},
  pages = {394-400},
  note = {cited By (since 1996)1},
  url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-81255144702&partnerID=40&md5=5253b7f489a57e614e109a657e55996b},
  affiliation = {Medical Physics, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom; MR Elastography Group, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; School of Engineering, University of Edinburgh, Alexander Graham Bell Building, Edinburgh EH9 3JL, United Kingdom; Clinical Research Imaging Centre, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom},
  abstract = {The clinical assessment of the rupture risk of atherosclerotic plaque is made by imaging the reduction of the lumen; via ultrasound or angiography. It is known that this is an imperfect criterion and that other characteristics of the plaque, such as the change in mechanical properties, may be more relevant. Magnetic Resonance Elastography (MRE) is a novel imaging technique that measures tissue stiffness. Magnetic resonance imaging measures the tissue displacement in response to harmonic shear waves excited on the surface of the body by a vibrating actuator. The images of wave propagation are transformed into an image of stiffness using an inversion algorithm. A steady state analysis was conducted on a simulation of MRE shear waves propagating through an idealised atherosclerotic plaque. The variation of the 2D complex wave response was investigated with regards to stenosis size, lipid pool size and excitation frequency. The detectability of small lipid pools was shown to increase with frequency. However significant wave disruptions were observed at higher excitation frequencies. This study shall form the basis for future work on incorporating an inversion algorithm into the simulation.},
  author_keywords = {Atherosclerosis;  Finite element analysis;  Magnetic resonance elastography;  Plaque rupture;  Shear waves},
  references = {Mathers, C.D., Bernard, C., Iburg, K.M., Inoue, M., Ma Fat, D., Shibuya, K., Global burden of disease in 2002: data sources, methods and results (2003) World Health Organization, , Dec; Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Heart disease and stroke statistics - 2007 update: A report from the American heart association statistics committee and stroke statistics subcommittee (2006) Circulation, 115, pp. e96-e171. , Dec; Farrell, B., Fraser, A., Sandercock, P., Slattery, J., Warlow, C.P., Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European carotid surgery trail (ECST) (1998) Lancet, 351, pp. 1379-1387. , May; Rothwell, P.M., Gutnikov, S.A., Warlow, C.P., Reanalysis of the final results of the European carotid surgery trail (2003) Stroke, 34, pp. 514-523. , Jan; Tang, T., Howarth, S.P.S., Miller, S.R., Trivedi, R., Graves, M.J., King-Im, J.U., Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI (2006) Stroke, 37, pp. 2266-2270. , Sep; Yuan, C., Mitsumori, L.M., Ferguson, M.S., Polissar, N.L., Echelard, D., Ortiz, G., In vivo accuracy of multispectral magentic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques (2001) Circulation, 104, pp. 2051-2056. , Oct; Li, Z.Y., Howarth, S., Trivedi, R.A., King-Im, J.M.U., Graves, M.J., Brown, A., Stress analysis of carotid plaque rupture based on in vivo high resolution MRI (2006) Journal of Biomechanics, 39, pp. 2611-2622. , Aug; Dahl, J.J., Dumont, D.M., Allen, J.D., Miller, E.M., Trahey, G.E., Acoustic radiation force impulse imaging for noninvasive characterization of carotid artery atherosclerotic plaques: A feasibility study (2006) Ultrasound Med. Biol., 35, pp. 707-716. , May; Lee, R.T., Libby, P., The unstable atheroma (1997) Arterioscler. Throm. Vasc. Biol., 17, pp. 1859-1867. , Oct; Falk, E., Shah, P.K., Fuster, V., Coronary plaque disruption (1995) Circulation, 92, pp. 657-671. , Aug; Loree, H.M., Tobias, B.J., Gibson, L.J., Kamm, R.D., Small, D.M., Lee, R.T., Mechanical properties of model atherosclerotic lesion lipid pools (1994) Arterioscler. Throm. Vasc. Biol., 14, pp. 230-234. , Feb; Lendon, C.L., Davies, M.J., Born, G.V.R., Richardson, P.D., Atherosclerotic plaque caps are locally weakened when macrophages density is increased (1991) Atherosclerosis, 87, pp. 87-90. , Mar; Muthupillai, R., Lomas, D.J., Rossman, P.J., Greenleaf, J.F., Manduca, A., Ehamn, R.L., Magnetic resonance elastography by direct visualization of propagating acoustic strain waves (1995) Science, 269, pp. 1854-1857. , Sep; Klatt, D., Asbach, P., Rump, J., Papazoglou, S., Somasundaram, R., Modrow, J., In vivo determination of hepatic stiffness using steady-state free precession magnetic resonance elastography (2006) Investigative Radiology, 41, pp. 841-848. , Dec; Thomas-Seale, L., Pankaj, P., Roberts, N., Hoskins, P., Computational modelling of magnetic resonance elastography shear wave behaviour through atherosclerotic plaque with disease development (2011) Lecture Notes in Engineering and Computer Science: Proceedings of The World Congress of Engineering 2011, pp. 2636-2639. , WCE 6-8 July, London U.K; Woodrum, D.A., Romano, A.J., Lerman, A., Pandya, U.H., Brosh, D., Rossman, P.J., Vascular wall elasticity measurement by magnetic resonance imaging (2006) Magn. Reson. Med., 56, pp. 593-600. , Aug; Woodrum, D.A., Herrmann, J., Lerman, A., Romano, A.J., Lerman, L.O., Ehman, R.L., Phase contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall (2009) J. Magn. Reson. Imaging, 29, pp. 583-587; Zheng, Y., Chan, Q.C.C., Yang, E.S., Magnetic resonance elastography with twin drivers for high homogeneity and sensitivity (2007) Proc. 28th IEEE EMBS Annual Int. Conf., pp. 1916-1919. , New York; Kolipaka, A., Woodrum, D.A., Gorny, K.R., Garcia Medina, O.I., Romano, A.J., Ehman, R.L., MR elastography of the in vivo abdominal aorta: feasibility study (2010) Proc. Int. Soc. Mag. Reson. Med., 18, p. 1257. , Stockholm; Schulze-Bauer, C.A.J., Mörth, C., Holzapfel, G.A., Passive biaxial mechanical response of aged human iliac arteries (2003) J. Biomech. Eng., 125, pp. 395-406. , Jun; Tang, D., Yang, C., Kobayashi, S., Ku, D.N., Effect of a lipid pool on the stress/strain distributions in stenotic arteries: 3-D fluidstructure interactions (FSI) models (2004) J. Biomech. Eng., 126, pp. 363-370. , Jun; Li, M., (2006) Numerical simulation of blood flow and vessel wall stresses in stenosed arteries, , Ph.D dissertation, Dept. Medical Physics, Edinburgh Univ., Edinburgh, UK; Holzapfel, G.A., Stadler, M., Schulze-Bauer, C.A.J., A layerspecific three-dimensional model for the simulation of balloon angioplasty using magnetic resonance imaging and mechanical testing (2002) Ann. Biomed. Eng., 30, pp. 753-767. , Jun; Hoskins, P.R., Martin, K., Thrush, A., (2010) Diagnostic ultrasound: physics and equipment, , 2nd ed. Cambridge Univ. Press; Braun, J., Buntkowsky, G., Bernarding, J., Tolxdorff, T., Sack, I., Simulation and analysis of magnetic resonance elastography wave images using coupled harmonic oscillators and Gaussian local frequency estimation (2001) Magn. Reson. Imaging, 19, pp. 703-713. , Feb; Hoskins, P.R., Physical properties of tissues relevant to arterial ultrasound imaging and blood velocity measurement (2007) Ultrasound Med. Biol., 33, pp. 1527-1539. , Oct; Sinkus, R., Lorenzen, J., Schrade, D., Lorenzen, M., Dargatz, M., Holz, D., High-resolution tensor MR elastography for breast tumour detection (2000) Phys. Med. Biol., 34, pp. 1649-1664. , Nov; Parker, K.J., Taylor, L.S., Gracewski, S., Rubens, D.J., A unified view of imaging the elastic properties of tissue (2005) J. Acoust. Soc. Am., 117, pp. 2705-2712. , May; Papazoglou, S., Hamhaber, U., Braun, J., Sack, I., Algebraic Helmholtz inversion in planar magnetic resonance elastography (2008) Phys. Med. Biol., 53, pp. 3147-3158. , May; Carstensen, E.L., Parker, K.J., Lerner, R.M., Elastography in the management of liver disease (2008) Ultrasound Med. Biol., 34, pp. 1535-1546. , Oct; Klatt, D., Hamhaber, U., Asbach, P., Braun, J., Sack, I., Noninvasive assessment of the rheological behaviour of human organs using multifrequency MR elastography: A study of brain and liver viscoelasticity (2007) Phys. Med. Biol., 52, pp. 7281-7294. , Nov},
  correspondence_address1 = {Thomas-Seale, L.E.J.; Medical Physics, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom; email: Thomas@sms.ed.ac.uk},
  issn = {1819656X},
  language = {English},
  abbrev_source_title = {IAENG Int. J. Comput. Sci.},
  document_type = {Article},
  source = {Scopus}
}

Downloads: 0