A prospective multi-center observational study of children hospitalized with diarrhea in Ho Chi Minh City, Vietnam. Thompson, C. N., Phan, M. V. T., Hoang, N. V. M., Minh, P. V., Vinh, N. T., Thuy, C. T., Nga, T. T. T., Rabaa, M. A., Duy, P. T., Dung, T. T. N., Phat, V. V., Nga, T. V. T., Tu, L. T. P., Tuyen, H. T., Yoshihara, K., Jenkins, C., Duong, V. T., Phuc, H. L., Tuyet, P. T. N., Ngoc, N. M., Vinh, H., Chinh, N. T., Thuong, T. C., Tuan, H. M., Hien, T. T., Campbell, J. I., Chau, N. V. V., Thwaites, G., & Baker, S. The American journal of tropical medicine and hygiene, 92(5):1045–1052, May, 2015. doi abstract bibtex We performed a prospective multicenter study to address the lack of data on the etiology, clinical and demographic features of hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic and 609 non-diarrheal control) children were enrolled in three hospitals over a 1-year period in 2009-2010. Aiming to detect a panel of pathogens, we identified a known diarrheal pathogen in stool samples from 1,067/1,419 (75.2%) children with diarrhea and from 81/609 (13.3%) children without diarrhea. Rotavirus predominated in the symptomatic children (664/1,419; 46.8%), followed by norovirus (293/1,419; 20.6%). The bacterial pathogens Salmonella, Campylobacter, and Shigella were cumulatively isolated from 204/1,419 (14.4%) diarrheal children and exhibited extensive antimicrobial resistance, most notably to fluoroquinolones and third-generation cephalosporins. We suggest renewed efforts in generation and implementation of policies to control the sale and prescription of antimicrobials to curb bacterial resistance and advise consideration of a subsidized rotavirus vaccination policy to limit the morbidity due to diarrheal disease in Vietnam.
@article{thompson_prospective_2015,
title = {A prospective multi-center observational study of children hospitalized with diarrhea in {Ho} {Chi} {Minh} {City}, {Vietnam}.},
volume = {92},
copyright = {(c) The American Society of Tropical Medicine and Hygiene.},
issn = {1476-1645 0002-9637},
doi = {10.4269/ajtmh.14-0655},
abstract = {We performed a prospective multicenter study to address the lack of data on the etiology, clinical and demographic features of hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic and 609 non-diarrheal control) children were enrolled in three hospitals over a 1-year period in 2009-2010. Aiming to detect a panel of pathogens, we identified a known diarrheal pathogen in stool samples from 1,067/1,419 (75.2\%) children with diarrhea and from 81/609 (13.3\%) children without diarrhea. Rotavirus predominated in the symptomatic children (664/1,419; 46.8\%), followed by norovirus (293/1,419; 20.6\%). The bacterial pathogens Salmonella, Campylobacter, and Shigella were cumulatively isolated from 204/1,419 (14.4\%) diarrheal children and exhibited extensive antimicrobial resistance, most notably to fluoroquinolones and third-generation cephalosporins. We suggest renewed efforts in generation and implementation of policies to control the sale and prescription of antimicrobials to curb bacterial resistance and advise consideration of a subsidized rotavirus vaccination policy to limit the morbidity due to diarrheal disease in Vietnam.},
language = {eng},
number = {5},
journal = {The American journal of tropical medicine and hygiene},
author = {Thompson, Corinne N. and Phan, My V. T. and Hoang, Nguyen Van Minh and Minh, Pham Van and Vinh, Nguyen Thanh and Thuy, Cao Thu and Nga, Tran Thi Thu and Rabaa, Maia A. and Duy, Pham Thanh and Dung, Tran Thi Ngoc and Phat, Voong Vinh and Nga, Tran Vu Thieu and Tu, Le Thi Phuong and Tuyen, Ha Thanh and Yoshihara, Keisuke and Jenkins, Claire and Duong, Vu Thuy and Phuc, Hoang Le and Tuyet, Pham Thi Ngoc and Ngoc, Nguyen Minh and Vinh, Ha and Chinh, Nguyen Tran and Thuong, Tang Chi and Tuan, Ha Manh and Hien, Tran Tinh and Campbell, James I. and Chau, Nguyen Van Vinh and Thwaites, Guy and Baker, Stephen},
month = may,
year = {2015},
pmid = {25802437},
pmcid = {PMC4426562},
keywords = {Anti-Infective Agents/pharmacology, Bacteria/drug effects, Bacterial Infections/complications/*epidemiology/microbiology, Caliciviridae Infections/complications/*epidemiology/microbiology, Child, Preschool, Cross-Sectional Studies, Demography, Diarrhea/*complications/epidemiology/microbiology, Female, Hospitalization, Humans, Infant, Male, Microbial Sensitivity Tests, Norovirus/drug effects/*isolation \& purification, Prospective Studies, Rotavirus Infections/complications/*epidemiology/microbiology, Rotavirus/drug effects/isolation \& purification, Seasons, Vietnam/epidemiology},
pages = {1045--1052},
}
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