@article{
 title = {Genetics, statistics and human disease: analytical retooling for complexity},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Genetics, Medical/methods/trends,*Models, Genetic,Genetic Diseases, Inborn/genetics,Genetic Heterogeneity,Humans,Models, Statistical,Phenotype,Polymorphism, Single Nucleotide,Quantitative Trait Loci},
 pages = {640-647},
 volume = {20},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15522460},
 edition = {2004/11/04},
 id = {7e3cf755-09be-3d02-a33f-d1ddbd837f4d},
 created = {2017-06-19T13:42:11.849Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
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 last_modified = {2017-06-19T13:42:11.984Z},
 read = {false},
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 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Thornton-Wells, Tricia A<m:linebreak/>Moore, Jason H<m:linebreak/>Haines, Jonathan L<m:linebreak/>A619085/PHS HHS/United States<m:linebreak/>AI 59694/AI/NIAID NIH HHS/United States<m:linebreak/>HL 65234/HL/NHLBI NIH HHS/United States<m:linebreak/>NS 32830/NS/NINDS NIH HHS/United States<m:linebreak/>T32 MH 64913/MH/NIMH NIH HHS/United States<m:linebreak/>Research Support, U.S. Gov't, P.H.S.<m:linebreak/>Review<m:linebreak/>England<m:linebreak/>Trends in genetics : TIG<m:linebreak/>S0168-9525(04)00274-4<m:linebreak/>Trends Genet. 2004 Dec;20(12):640-7.</m:note>},
 abstract = {Molecular biologists and geneticists alike now acknowledge that most common human diseases with a genetic component are likely to have complex etiologies. Yet despite this belief, many statistical geneticists continue applying, in slightly new and different ways, methodologies that were developed to dissect much simpler etiologies. In this article, we characterize, with examples, the various factors that can complicate genetic analysis and demonstrate their shared features and how they affect genetic analysis. We describe a variety of approaches that are currently available, revealing methodological gaps and suggesting new directions for method development. Finally, we propose a comprehensive two-step approach to analysis that systemically addresses the different genetic factors that are likely to underlie complex diseases.},
 bibtype = {article},
 author = {Thornton-Wells, T A and Moore, J H and Haines, J L},
 journal = {Trends Genet},
 number = {12}
}

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