Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study. Tore, E. C., Elshorbagy, A. K., Bakers, F. C. H., Brouwers, M., Dagnelie, P. C., Eussen, S., Jansen, J. F. A., Kooi, M. E., Kusters, Y., Meex, S. J. R., Olsen, T., Refsum, H., Retterstol, K., Schalkwijk, C. G., Stehouwer, C. D. A., Vinknes, K. J., & van Greevenbroek, M. M. J. Eur J Nutr, 2022. Tore, Elena C Elshorbagy, Amany K Bakers, Frans C H Brouwers, Martijn C G J Dagnelie, Pieter C Eussen, Simone J P M Jansen, Jacobus F A Kooi, M Eline Kusters, Yvo H A M Meex, Steven J R Olsen, Thomas Refsum, Helga Retterstol, Kjetil Schalkwijk, Casper G Stehouwer, Coen D A Vinknes, Kathrine J van Greevenbroek, Marleen M J eng 940-35-034/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/ 98.901/Diabetes Fonds/ grant 31O.041/Ministerie van Economische Zaken/ GA N degrees 727565/Horizon 2020/ Germany Eur J Nutr. 2022 Nov 2. doi: 10.1007/s00394-022-03041-4.![Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex PURPOSE: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. METHODS: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC-MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. RESULTS: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: beta = 0.19 (0.09, 0.28); DMS: beta = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: beta = 0.15 (0.08, 0.23); DMS: beta = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: beta = 0.16 (0.08, 0.25); DMS: beta = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. CONCLUSION: Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts.
@article{RN312,
author = {Tore, E. C. and Elshorbagy, A. K. and Bakers, F. C. H. and Brouwers, Mcgj and Dagnelie, P. C. and Eussen, Sjpm and Jansen, J. F. A. and Kooi, M. E. and Kusters, Yham and Meex, S. J. R. and Olsen, T. and Refsum, H. and Retterstol, K. and Schalkwijk, C. G. and Stehouwer, C. D. A. and Vinknes, K. J. and van Greevenbroek, M. M. J.},
title = {Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study},
journal = {Eur J Nutr},
note = {Tore, Elena C
Elshorbagy, Amany K
Bakers, Frans C H
Brouwers, Martijn C G J
Dagnelie, Pieter C
Eussen, Simone J P M
Jansen, Jacobus F A
Kooi, M Eline
Kusters, Yvo H A M
Meex, Steven J R
Olsen, Thomas
Refsum, Helga
Retterstol, Kjetil
Schalkwijk, Casper G
Stehouwer, Coen D A
Vinknes, Kathrine J
van Greevenbroek, Marleen M J
eng
940-35-034/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/
98.901/Diabetes Fonds/
grant 31O.041/Ministerie van Economische Zaken/
GA N degrees 727565/Horizon 2020/
Germany
Eur J Nutr. 2022 Nov 2. doi: 10.1007/s00394-022-03041-4.},
abstract = {PURPOSE: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. METHODS: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC-MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. RESULTS: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: beta = 0.19 (0.09, 0.28); DMS: beta = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: beta = 0.15 (0.08, 0.23); DMS: beta = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: beta = 0.16 (0.08, 0.25); DMS: beta = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. CONCLUSION: Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts.},
keywords = {Adiposity
Liver fat
Regional fat distribution
Sulfur amino acids},
ISSN = {1436-6215 (Electronic)
1436-6207 (Linking)},
DOI = {10.1007/s00394-022-03041-4},
url = {https://www.ncbi.nlm.nih.gov/pubmed/36322288},
year = {2022},
type = {Journal Article}
}
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{"_id":"zbMgzL7q7fHm69ck6","bibbaseid":"tore-elshorbagy-bakers-brouwers-dagnelie-eussen-jansen-kooi-etal-associationsbetweenplasmasulfuraminoacidsandspecificfatdepotsintwoindependentcohortscodamandthemaastrichtstudy-2022","author_short":["Tore, E. C.","Elshorbagy, A. K.","Bakers, F. C. H.","Brouwers, M.","Dagnelie, P. C.","Eussen, S.","Jansen, J. F. A.","Kooi, M. E.","Kusters, Y.","Meex, S. J. R.","Olsen, T.","Refsum, H.","Retterstol, K.","Schalkwijk, C. G.","Stehouwer, C. D. A.","Vinknes, K. J.","van Greevenbroek, M. M. J."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Tore"],"firstnames":["E.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Elshorbagy"],"firstnames":["A.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Bakers"],"firstnames":["F.","C.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Brouwers"],"firstnames":["Mcgj"],"suffixes":[]},{"propositions":[],"lastnames":["Dagnelie"],"firstnames":["P.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Eussen"],"firstnames":["Sjpm"],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kooi"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Kusters"],"firstnames":["Yham"],"suffixes":[]},{"propositions":[],"lastnames":["Meex"],"firstnames":["S.","J.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Olsen"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Refsum"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Retterstol"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Schalkwijk"],"firstnames":["C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Vinknes"],"firstnames":["K.","J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Greevenbroek"],"firstnames":["M.","M.","J."],"suffixes":[]}],"title":"Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study","journal":"Eur J Nutr","note":"Tore, Elena C Elshorbagy, Amany K Bakers, Frans C H Brouwers, Martijn C G J Dagnelie, Pieter C Eussen, Simone J P M Jansen, Jacobus F A Kooi, M Eline Kusters, Yvo H A M Meex, Steven J R Olsen, Thomas Refsum, Helga Retterstol, Kjetil Schalkwijk, Casper G Stehouwer, Coen D A Vinknes, Kathrine J van Greevenbroek, Marleen M J eng 940-35-034/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/ 98.901/Diabetes Fonds/ grant 31O.041/Ministerie van Economische Zaken/ GA N degrees 727565/Horizon 2020/ Germany Eur J Nutr. 2022 Nov 2. doi: 10.1007/s00394-022-03041-4.","abstract":"PURPOSE: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. METHODS: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC-MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. RESULTS: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: beta = 0.19 (0.09, 0.28); DMS: beta = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: beta = 0.15 (0.08, 0.23); DMS: beta = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: beta = 0.16 (0.08, 0.25); DMS: beta = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. CONCLUSION: Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts.","keywords":"Adiposity Liver fat Regional fat distribution Sulfur amino acids","issn":"1436-6215 (Electronic) 1436-6207 (Linking)","doi":"10.1007/s00394-022-03041-4","url":"https://www.ncbi.nlm.nih.gov/pubmed/36322288","year":"2022","bibtex":"@article{RN312,\n author = {Tore, E. C. and Elshorbagy, A. K. and Bakers, F. C. H. and Brouwers, Mcgj and Dagnelie, P. C. and Eussen, Sjpm and Jansen, J. F. A. and Kooi, M. E. and Kusters, Yham and Meex, S. J. R. and Olsen, T. and Refsum, H. and Retterstol, K. and Schalkwijk, C. G. and Stehouwer, C. D. A. and Vinknes, K. J. and van Greevenbroek, M. M. J.},\n title = {Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study},\n journal = {Eur J Nutr},\n note = {Tore, Elena C\nElshorbagy, Amany K\nBakers, Frans C H\nBrouwers, Martijn C G J\nDagnelie, Pieter C\nEussen, Simone J P M\nJansen, Jacobus F A\nKooi, M Eline\nKusters, Yvo H A M\nMeex, Steven J R\nOlsen, Thomas\nRefsum, Helga\nRetterstol, Kjetil\nSchalkwijk, Casper G\nStehouwer, Coen D A\nVinknes, Kathrine J\nvan Greevenbroek, Marleen M J\neng\n940-35-034/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/\n98.901/Diabetes Fonds/\ngrant 31O.041/Ministerie van Economische Zaken/\nGA N degrees 727565/Horizon 2020/\nGermany\nEur J Nutr. 2022 Nov 2. doi: 10.1007/s00394-022-03041-4.},\n abstract = {PURPOSE: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. METHODS: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC-MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. RESULTS: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: beta = 0.19 (0.09, 0.28); DMS: beta = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: beta = 0.15 (0.08, 0.23); DMS: beta = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: beta = 0.16 (0.08, 0.25); DMS: beta = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. 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