Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?. Torres-Santiago L., Mauras N., Hossain J., Weltman A.L., & Darmaun D. 2017. ![Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Objective The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50% versus 33%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.
@misc{torres-santiago_l._does_2017,
title = {Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?},
url = {http://www.elsevier.com/locate/nut},
abstract = {Objective The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1\%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50\% versus 33\%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.},
journal = {Nutrition},
author = {{Torres-Santiago L.} and {Mauras N.} and {Hossain J.} and {Weltman A.L.} and {Darmaun D.}},
year = {2017},
keywords = {*clamp, *glucagon like peptide 1, *glutamine, *glutamine/ae [Adverse Drug Reaction], *glutamine/cm [Drug Comparison], *glutamine/dt [Drug Therapy], *glutamine/po [Oral Drug Administration], *hyperinsulinism, *hypoglycemia, *insulin dependent diabetes mellitus, *insulin dependent diabetes mellitus/dt [Drug Therapy], *insulin sensitivity, *isotope, *treadmill, adolescent, antidiabetic agent, article, blood glucose monitoring, body mass, carbohydrate intake, clinical article, clinical trial, controlled clinical trial, controlled study, crossover procedure, disease duration, double blind procedure, exercise, fatty acid/ec [Endogenous Compound], female, glucagon like peptide 1/ec [Endogenous Compound], gluconeogenesis, glucose blood level, glucose homeostasis, glucose infusion, glucose metabolism, glucose tolerance, glycemic control, glycogen synthesis, hemoglobin A1c, hemoglobin A1c/ec [Endogenous Compound], human, hyperinsulinemic euglycemic clamp technique, hypoglycemia/si [Side Effect], incidence, insulin dependent diabetes mellitus/dt [Drug Therapy], insulin resistance, lipolysis, male, placebo, priority journal, probability, puberty, randomized controlled trial, rest, sex ratio, treadmill exercise}
}
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Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50% versus 33%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.","journal":"Nutrition","author":[{"firstnames":[],"propositions":[],"lastnames":["Torres-Santiago L."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Mauras N."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Hossain J."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Weltman A.L."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Darmaun D."],"suffixes":[]}],"year":"2017","keywords":"*clamp, *glucagon like peptide 1, *glutamine, *glutamine/ae [Adverse Drug Reaction], *glutamine/cm [Drug Comparison], *glutamine/dt [Drug Therapy], *glutamine/po [Oral Drug Administration], *hyperinsulinism, *hypoglycemia, *insulin dependent diabetes mellitus, *insulin dependent diabetes mellitus/dt [Drug Therapy], *insulin sensitivity, *isotope, *treadmill, adolescent, antidiabetic agent, article, blood glucose monitoring, body mass, carbohydrate intake, clinical article, clinical trial, controlled clinical trial, controlled study, crossover procedure, disease duration, double blind procedure, exercise, fatty acid/ec [Endogenous Compound], female, glucagon like peptide 1/ec [Endogenous Compound], gluconeogenesis, glucose blood level, glucose homeostasis, glucose infusion, glucose metabolism, glucose tolerance, glycemic control, glycogen synthesis, hemoglobin A1c, hemoglobin A1c/ec [Endogenous Compound], human, hyperinsulinemic euglycemic clamp technique, hypoglycemia/si [Side Effect], incidence, insulin dependent diabetes mellitus/dt [Drug Therapy], insulin resistance, lipolysis, male, placebo, priority journal, probability, puberty, randomized controlled trial, rest, sex ratio, treadmill exercise","bibtex":"@misc{torres-santiago_l._does_2017,\n\ttitle = {Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?},\n\turl = {http://www.elsevier.com/locate/nut},\n\tabstract = {Objective The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1\\%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50\\% versus 33\\%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.},\n\tjournal = {Nutrition},\n\tauthor = {{Torres-Santiago L.} and {Mauras N.} and {Hossain J.} and {Weltman A.L.} and {Darmaun D.}},\n\tyear = {2017},\n\tkeywords = {*clamp, *glucagon like peptide 1, *glutamine, *glutamine/ae [Adverse Drug Reaction], *glutamine/cm [Drug Comparison], *glutamine/dt [Drug Therapy], *glutamine/po [Oral Drug Administration], *hyperinsulinism, *hypoglycemia, *insulin dependent diabetes mellitus, *insulin dependent diabetes mellitus/dt [Drug Therapy], *insulin sensitivity, *isotope, *treadmill, adolescent, antidiabetic agent, article, blood glucose monitoring, body mass, carbohydrate intake, clinical article, clinical trial, controlled clinical trial, controlled study, crossover procedure, disease duration, double blind procedure, exercise, fatty acid/ec [Endogenous Compound], female, glucagon like peptide 1/ec [Endogenous Compound], gluconeogenesis, glucose blood level, glucose homeostasis, glucose infusion, glucose metabolism, glucose tolerance, glycemic control, glycogen synthesis, hemoglobin A1c, hemoglobin A1c/ec [Endogenous Compound], human, hyperinsulinemic euglycemic clamp technique, hypoglycemia/si [Side Effect], incidence, insulin dependent diabetes mellitus/dt [Drug Therapy], insulin resistance, lipolysis, male, placebo, priority journal, probability, puberty, randomized controlled trial, rest, sex ratio, treadmill exercise}\n}\n","author_short":["Torres-Santiago L.","Mauras N.","Hossain J.","Weltman A.L.","Darmaun D."],"key":"torres-santiago_l._does_2017","id":"torres-santiago_l._does_2017","bibbaseid":"torressantiagol-maurasn-hossainj-weltmanal-darmaund-doesoralglutamineimproveinsulinsensitivityinadolescentswithtype1diabetes-2017","role":"author","urls":{"Paper":"http://www.elsevier.com/locate/nut"},"keyword":["*clamp","*glucagon like peptide 1","*glutamine","*glutamine/ae [Adverse Drug Reaction]","*glutamine/cm [Drug Comparison]","*glutamine/dt [Drug Therapy]","*glutamine/po [Oral Drug Administration]","*hyperinsulinism","*hypoglycemia","*insulin dependent diabetes mellitus","*insulin dependent diabetes mellitus/dt [Drug Therapy]","*insulin sensitivity","*isotope","*treadmill","adolescent","antidiabetic agent","article","blood glucose monitoring","body mass","carbohydrate intake","clinical article","clinical trial","controlled clinical trial","controlled study","crossover procedure","disease duration","double blind procedure","exercise","fatty acid/ec [Endogenous Compound]","female","glucagon like peptide 1/ec [Endogenous Compound]","gluconeogenesis","glucose blood level","glucose homeostasis","glucose infusion","glucose metabolism","glucose tolerance","glycemic control","glycogen synthesis","hemoglobin A1c","hemoglobin A1c/ec [Endogenous Compound]","human","hyperinsulinemic euglycemic clamp technique","hypoglycemia/si [Side Effect]","incidence","insulin dependent diabetes mellitus/dt [Drug Therapy]","insulin resistance","lipolysis","male","placebo","priority journal","probability","puberty","randomized controlled trial","rest","sex ratio","treadmill exercise"],"downloads":0,"html":""},"search_terms":["oral","glutamine","improve","insulin","sensitivity","adolescents","type","diabetes","torres-santiago l.","mauras n.","hossain j.","weltman a.l.","darmaun d."],"keywords":["*clamp","*glucagon like peptide 1","*glutamine","*glutamine/ae [adverse drug reaction]","*glutamine/cm [drug comparison]","*glutamine/dt [drug therapy]","*glutamine/po [oral drug administration]","*hyperinsulinism","*hypoglycemia","*insulin dependent diabetes mellitus","*insulin dependent diabetes mellitus/dt [drug therapy]","*insulin sensitivity","*isotope","*treadmill","adolescent","antidiabetic agent","article","blood glucose monitoring","body mass","carbohydrate intake","clinical article","clinical trial","controlled clinical trial","controlled study","crossover procedure","disease duration","double blind procedure","exercise","fatty acid/ec [endogenous compound]","female","glucagon like peptide 1/ec [endogenous compound]","gluconeogenesis","glucose blood level","glucose homeostasis","glucose infusion","glucose metabolism","glucose tolerance","glycemic control","glycogen synthesis","hemoglobin a1c","hemoglobin a1c/ec [endogenous compound]","human","hyperinsulinemic euglycemic clamp technique","hypoglycemia/si [side effect]","incidence","insulin dependent diabetes mellitus/dt [drug therapy]","insulin resistance","lipolysis","male","placebo","priority journal","probability","puberty","randomized controlled trial","rest","sex ratio","treadmill exercise"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}