@misc{totonchi_z._effect_2017,
	title = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial},
	url = {http://cardiovascmed.com/72535.pdf},
	abstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.},
	journal = {Research in Cardiovascular Medicine},
	author = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}},
	year = {2017},
	keywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]}
}

{"_id":"3ePBBs93rhLpBYSk6","bibbaseid":"totonchiz-rezvanih-ghorbanloom-yazdanianf-mahdavim-babaalin-salajeghehs-chitsazanm-effectofdexmedetomidineinfusiononhemodynamicsandstressresponsesinpediatriccardiacsurgeryarandomizedtrial-2017","downloads":0,"creationDate":"2017-05-12T20:20:57.730Z","title":"Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: A randomized trial","author_short":["Totonchi Z.","Rezvani H.","Ghorbanloo M.","Yazdanian F.","Mahdavi M.","Babaali N.","Salajegheh S.","Chitsazan M."],"year":2017,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: A randomized trial","url":"http://cardiovascmed.com/72535.pdf","abstract":"Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.","journal":"Research in Cardiovascular Medicine","author":[{"firstnames":[],"propositions":[],"lastnames":["Totonchi Z."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Rezvani H."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Ghorbanloo M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Yazdanian F."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Mahdavi M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Babaali N."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Salajegheh S."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Chitsazan M."],"suffixes":[]}],"year":"2017","keywords":"*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]","bibtex":"@misc{totonchi_z._effect_2017,\n\ttitle = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial},\n\turl = {http://cardiovascmed.com/72535.pdf},\n\tabstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.},\n\tjournal = {Research in Cardiovascular Medicine},\n\tauthor = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}},\n\tyear = {2017},\n\tkeywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]}\n}\n\n","author_short":["Totonchi Z.","Rezvani H.","Ghorbanloo M.","Yazdanian F.","Mahdavi M.","Babaali N.","Salajegheh S.","Chitsazan M."],"key":"totonchi_z._effect_2017","id":"totonchi_z._effect_2017","bibbaseid":"totonchiz-rezvanih-ghorbanloom-yazdanianf-mahdavim-babaalin-salajeghehs-chitsazanm-effectofdexmedetomidineinfusiononhemodynamicsandstressresponsesinpediatriccardiacsurgeryarandomizedtrial-2017","role":"author","urls":{"Paper":"http://cardiovascmed.com/72535.pdf"},"keyword":["*chemical stress","*dexmedetomidine","*dexmedetomidine/ct [Clinical Trial]","*diastolic blood pressure","*heart surgery","*hemodynamics","*infusion","*open heart surgery","*stress","Anesthesia","C reactive protein","C reactive protein/ec [Endogenous Compound]","Child","adjuvant","artery catheter","article","cardiopulmonary bypass","central venous catheter","central venous pressure","clinical article","clinical trial","continuous infusion","control group","controlled clinical trial","controlled study","diastolic blood pressure","drug therapy","endogenous compound","female","fentanyl","heart rate","human","hypertension","hypotension","incidence","infant","inflammation","intensive care unit","interleukin 6","interleukin 6/ec [Endogenous Compound]","lactate dehydrogenase/ec [Endogenous Compound]","lactic acid","loading drug dose","lymphotoxin beta","maintenance drug dose","male","midazolam","normal human","preschool child","prospective study","randomized controlled trial","sampling","single blind procedure","skin incision","sodium chloride","sternotomy","systolic blood pressure","tumor necrosis factor/ec [Endogenous Compound]"],"downloads":0,"html":""},"search_terms":["effect","dexmedetomidine","infusion","hemodynamics","stress","responses","pediatric","cardiac","surgery","randomized","trial","totonchi z.","rezvani h.","ghorbanloo m.","yazdanian f.","mahdavi m.","babaali n.","salajegheh s.","chitsazan m."],"keywords":["*chemical stress","*dexmedetomidine","*dexmedetomidine/ct [clinical trial]","*diastolic blood pressure","*heart surgery","*hemodynamics","*infusion","*open heart surgery","*stress","anesthesia","c reactive protein","c reactive protein/ec [endogenous compound]","child","adjuvant","artery catheter","article","cardiopulmonary bypass","central venous catheter","central venous pressure","clinical article","clinical trial","continuous infusion","control group","controlled clinical trial","controlled study","diastolic blood pressure","drug therapy","endogenous compound","female","fentanyl","heart rate","human","hypertension","hypotension","incidence","infant","inflammation","intensive care unit","interleukin 6","interleukin 6/ec [endogenous compound]","lactate dehydrogenase/ec [endogenous compound]","lactic acid","loading drug dose","lymphotoxin beta","maintenance drug dose","male","midazolam","normal human","preschool child","prospective study","randomized controlled trial","sampling","single blind procedure","skin incision","sodium chloride","sternotomy","systolic blood pressure","tumor necrosis factor/ec [endogenous compound]"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}