Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients. Tranquillo, J., Franz, M., Knollmann, B., Henriquez, A., Taylor, D., & Henriquez, C. j-AJP, 286(4):H1370--H1381, April, 2004.
  author =       "J.V. Tranquillo and M.R. Franz and B.C. Knollmann and
                 A.P. Henriquez and D.A. Taylor and C.S. Henriquez",
  title =        "Genesis of the monophasic action potential: role of
                 interstitial resistance and boundary gradients.",
  journal =      j-AJP,
  year =         "2004",
  month =        apr,
  volume =       "286",
  number =       "4",
  pages =        "H1370--H1381",
  robnote =      "The extracellular potential at the site of a
                 mechanical deformation has been shown to resemble the
                 underlying transmembrane action potential, providing a
                 minimally invasive way to access membrane dynamics. The
                 biophysical factors underlying the genesis of this
                 signal, however, are still poorly understood. With the
                 use of data from a recent experimental study in a
                 murine heart, a three-dimensional anisotropic bidomain
                 model of the mouse ventricular free wall was developed
                 to study the currents and potentials resulting from the
                 application of a point mechanical load on cardiac
                 tissue. The applied pressure is assumed to open
                 nonspecific pressure-sensitive channels depolarizing
                 the membrane, leading to monophasic currents at the
                 electrode edge that give rise to the monophasic action
                 potential (MAP). The results show that the magnitude
                 and the time course of the MAP are reproduced only for
                 certain combinations of local or global intracellular
                 and interstitial resistances that form a resting tissue
                 length constant that, if applied over the entire
                 domain, is smaller than that required to match the wave
                 speed. The results suggest that the application of
                 pressure not only causes local depolarization but also
                 changes local tissue properties, both of which appear
                 to play a critical role in the genesis of the MAP.",
  bibdate =      "Mon Nov 20 07:50:07 2006",

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