Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients. Tranquillo, J., Franz, M., Knollmann, B., Henriquez, A., Taylor, D., & Henriquez, C. j-AJP, 286(4):H1370--H1381, April, 2004. bibtex @Article{RSM:Tra2004,
author = "J.V. Tranquillo and M.R. Franz and B.C. Knollmann and
A.P. Henriquez and D.A. Taylor and C.S. Henriquez",
title = "Genesis of the monophasic action potential: role of
interstitial resistance and boundary gradients.",
journal = j-AJP,
year = "2004",
month = apr,
volume = "286",
number = "4",
pages = "H1370--H1381",
robnote = "The extracellular potential at the site of a
mechanical deformation has been shown to resemble the
underlying transmembrane action potential, providing a
minimally invasive way to access membrane dynamics. The
biophysical factors underlying the genesis of this
signal, however, are still poorly understood. With the
use of data from a recent experimental study in a
murine heart, a three-dimensional anisotropic bidomain
model of the mouse ventricular free wall was developed
to study the currents and potentials resulting from the
application of a point mechanical load on cardiac
tissue. The applied pressure is assumed to open
nonspecific pressure-sensitive channels depolarizing
the membrane, leading to monophasic currents at the
electrode edge that give rise to the monophasic action
potential (MAP). The results show that the magnitude
and the time course of the MAP are reproduced only for
certain combinations of local or global intracellular
and interstitial resistances that form a resting tissue
length constant that, if applied over the entire
domain, is smaller than that required to match the wave
speed. The results suggest that the application of
pressure not only causes local depolarization but also
changes local tissue properties, both of which appear
to play a critical role in the genesis of the MAP.",
bibdate = "Mon Nov 20 07:50:07 2006",
}
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The biophysical factors underlying the genesis of this signal, however, are still poorly understood. With the use of data from a recent experimental study in a murine heart, a three-dimensional anisotropic bidomain model of the mouse ventricular free wall was developed to study the currents and potentials resulting from the application of a point mechanical load on cardiac tissue. The applied pressure is assumed to open nonspecific pressure-sensitive channels depolarizing the membrane, leading to monophasic currents at the electrode edge that give rise to the monophasic action potential (MAP). The results show that the magnitude and the time course of the MAP are reproduced only for certain combinations of local or global intracellular and interstitial resistances that form a resting tissue length constant that, if applied over the entire domain, is smaller than that required to match the wave speed. 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With the\n use of data from a recent experimental study in a\n murine heart, a three-dimensional anisotropic bidomain\n model of the mouse ventricular free wall was developed\n to study the currents and potentials resulting from the\n application of a point mechanical load on cardiac\n tissue. The applied pressure is assumed to open\n nonspecific pressure-sensitive channels depolarizing\n the membrane, leading to monophasic currents at the\n electrode edge that give rise to the monophasic action\n potential (MAP). The results show that the magnitude\n and the time course of the MAP are reproduced only for\n certain combinations of local or global intracellular\n and interstitial resistances that form a resting tissue\n length constant that, if applied over the entire\n domain, is smaller than that required to match the wave\n speed. The results suggest that the application of\n pressure not only causes local depolarization but also\n changes local tissue properties, both of which appear\n to play a critical role in the genesis of the MAP.\",\n bibdate = \"Mon Nov 20 07:50:07 2006\",\n}\n\n","author_short":["Tranquillo, J.","Franz, M.","Knollmann, B.","Henriquez, A.","Taylor, D.","Henriquez, C."],"key":"RSM:Tra2004","id":"RSM:Tra2004","bibbaseid":"tranquillo-franz-knollmann-henriquez-taylor-henriquez-genesisofthemonophasicactionpotentialroleofinterstitialresistanceandboundarygradients-2004","role":"author","urls":{},"downloads":0,"html":""},"search_terms":["genesis","monophasic","action","potential","role","interstitial","resistance","boundary","gradients","tranquillo","franz","knollmann","henriquez","taylor","henriquez"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}