@article{
 title = {Multivariable real-time optimal control of a cooling and antisolvent semibatch crystallization process},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {[Antisolvent semibatch crystallization, Atr-ftir,},
 volume = {55},
 id = {b6b58a53-314e-3bee-8ccd-16cb927ebe3d},
 created = {2016-10-13T17:09:53.000Z},
 file_attached = {false},
 profile_id = {4d1e5c71-f949-3edf-a702-2713dfe9c3ab},
 last_modified = {2017-03-21T21:57:19.025Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {This article presents an experimental study ofsimultaneous optimization with respect to two variables (cooling rate and flow-rate of antisolvent) in an offline and online (real-time) manner on a semibatch crystallizer. The nucleation and growth kinetic parameters ofparacetamol in an isopropanol-water cooling, antisolvent batch crystallizer were estimated by nonlinear regression in terms ofthe moments ofthe crystal population density. Moments ofcrystal population were estimated from the measured chord length distribution, generated by the FBRM®, and the supersaturation was calculated from the measured concentration by attenuated total reflectance-fourier transform infrared spectroscopy. The results of real-time optimization showed a substantial improvement ofthe end ofbatch properties (the volume-weighted mean size and yield). For the same objective function, the real-time optimization method resulted in an increase in the volume-weighted mean size by ∼100 fim and 15% of theoretical yield compared with the best result obtained in an offline optimization manner. © 2009 American Institute of Chemical Engineers.},
 bibtype = {article},
 author = {Trifkovic, M. and Sheikhzadeh, M. and Rohani, S.},
 journal = {AIChE Journal},
 number = {10}
}

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