Long-term prognosis after acute kidney injury requiring renal replacement therapy. Triverio, P., Martin, P., Romand, J., Pugin, J., Perneger, T., & Saudan, P. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association, 24(7):2186–2189, July, 2009.
doi  abstract   bibtex   
BACKGROUND: Data on the long-term survival and renal function of patients with acute kidney injury (AKI) treated with continuous renal replacement therapy are scarce. METHODS: We investigated the 3-year survival and need for chronic dialysis in critically ill patients, who had survived an episode of AKI requiring continuous renal replacement therapy. RESULTS: A total of 206 ICU patients with AKI were randomized in a trial comparing haemofiltration versus haemodiafiltration. Of these, 95 (46%) survived at 90 days. Post-discharge information relating to 3-year survival and renal function was successfully obtained in 89 (94%) of the patients. Of the 89 patients studied, chronic kidney disease (CKD) was present in 32 subjects from the onset, and CKD developed de novo in 25 patients following AKI. End-stage renal disease (ESRD) developed in 9 patients (of whom 8 had pre-existing CKD) and 29 patients died. Three-year survival was 67% overall; the mortality at 3 years was 50% for those with pre-existing kidney disease, and 71 and 82% for those with de novo and without CKD, respectively. CONCLUSION: After an episode of AKI necessitating a continuous renal replacement therapy, rapid progression to ESKD is commonly observed in patients with pre-existing chronic renal impairment. Medical care with an emphasis on nephroprotection is necessary in these patients.
@article{triverio_long-term_2009,
	title = {Long-term prognosis after acute kidney injury requiring renal replacement therapy},
	volume = {24},
	issn = {1460-2385},
	doi = {10.1093/ndt/gfp072},
	abstract = {BACKGROUND: Data on the long-term survival and renal function of patients with acute kidney injury (AKI) treated with continuous renal replacement therapy are scarce.
METHODS: We investigated the 3-year survival and need for chronic dialysis in critically ill patients, who had survived an episode of AKI requiring continuous renal replacement therapy.
RESULTS: A total of 206 ICU patients with AKI were randomized in a trial comparing haemofiltration versus haemodiafiltration. Of these, 95 (46\%) survived at 90 days. Post-discharge information relating to 3-year survival and renal function was successfully obtained in 89 (94\%) of the patients. Of the 89 patients studied, chronic kidney disease (CKD) was present in 32 subjects from the onset, and CKD developed de novo in 25 patients following AKI. End-stage renal disease (ESRD) developed in 9 patients (of whom 8 had pre-existing CKD) and 29 patients died. Three-year survival was 67\% overall; the mortality at 3 years was 50\% for those with pre-existing kidney disease, and 71 and 82\% for those with de novo and without CKD, respectively.
CONCLUSION: After an episode of AKI necessitating a continuous renal replacement therapy, rapid progression to ESKD is commonly observed in patients with pre-existing chronic renal impairment. Medical care with an emphasis on nephroprotection is necessary in these patients.},
	language = {eng},
	number = {7},
	journal = {Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association},
	author = {Triverio, Pierre-Alain and Martin, Pierre-Yves and Romand, Jacques and Pugin, Jerome and Perneger, Thomas and Saudan, Patrick},
	month = jul,
	year = {2009},
	pmid = {19228754},
	keywords = {Acute Kidney Injury, Aged, Female, Humans, Male, Middle Aged, Prognosis, Renal Replacement Therapy, Survival Rate, Time Factors},
	pages = {2186--2189}
}

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