@ARTICLE{Troyer1992-ro,
  title    = "Abnormal action-potential bursts and synchronized,
              {GABA-mediated} inhibitory potentials in an in vitro model of
              focal epilepsy",
  author   = "Troyer, M D and Blanton, M G and Kriegstein, A R",
  abstract = "Focal, freeze-induced lesions were made in isolated hemispheres
              of turtle cerebral cortex in vitro, permitting the investigation
              of epileptiform discharges in a preparation with preserved
              intracortical circuitry. Freeze lesions resulted in interictal
              discharges and occasional ictal-like events. The interictal
              discharges were dependent upon activation of non-NMDA excitatory
              amino acid receptors and were affected by but did not require
              NMDA receptor activation. Voltage clamp and current clamp
              recordings revealed abnormal bursts of low-amplitude action
              potentials in 36\% of recorded neurons, while large, repetitive
              inhibitory potentials, mediated by GABAA receptors, were recorded
              in 90\% of the neurons. Thus, prominent findings in this model
              include abnormalities of both excitatory and inhibitory activity.
              Since these changes in neuronal excitability resulted from a
              localized physical injury, they may resemble the changes that
              occur in acute posttraumatic epilepsy.",
  journal  = "Epilepsia",
  volume   =  33,
  number   =  2,
  pages    = "199--212",
  month    =  mar,
  year     =  1992,
  address  = "United States",
  language = "en"
}

{"_id":"vgYNZet63GMPQAG42","bibbaseid":"troyer-blanton-kriegstein-abnormalactionpotentialburstsandsynchronizedgabamediatedinhibitorypotentialsinaninvitromodeloffocalepilepsy-1992","author_short":["Troyer, M D","Blanton, M G","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Abnormal action-potential bursts and synchronized, GABA-mediated inhibitory potentials in an in vitro model of focal epilepsy","author":[{"propositions":[],"lastnames":["Troyer"],"firstnames":["M","D"],"suffixes":[]},{"propositions":[],"lastnames":["Blanton"],"firstnames":["M","G"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"Focal, freeze-induced lesions were made in isolated hemispheres of turtle cerebral cortex in vitro, permitting the investigation of epileptiform discharges in a preparation with preserved intracortical circuitry. Freeze lesions resulted in interictal discharges and occasional ictal-like events. The interictal discharges were dependent upon activation of non-NMDA excitatory amino acid receptors and were affected by but did not require NMDA receptor activation. Voltage clamp and current clamp recordings revealed abnormal bursts of low-amplitude action potentials in 36% of recorded neurons, while large, repetitive inhibitory potentials, mediated by GABAA receptors, were recorded in 90% of the neurons. Thus, prominent findings in this model include abnormalities of both excitatory and inhibitory activity. Since these changes in neuronal excitability resulted from a localized physical injury, they may resemble the changes that occur in acute posttraumatic epilepsy.","journal":"Epilepsia","volume":"33","number":"2","pages":"199–212","month":"March","year":"1992","address":"United States","language":"en","bibtex":"@ARTICLE{Troyer1992-ro,\n title = \"Abnormal action-potential bursts and synchronized,\n {GABA-mediated} inhibitory potentials in an in vitro model of\n focal epilepsy\",\n author = \"Troyer, M D and Blanton, M G and Kriegstein, A R\",\n abstract = \"Focal, freeze-induced lesions were made in isolated hemispheres\n of turtle cerebral cortex in vitro, permitting the investigation\n of epileptiform discharges in a preparation with preserved\n intracortical circuitry. Freeze lesions resulted in interictal\n discharges and occasional ictal-like events. The interictal\n discharges were dependent upon activation of non-NMDA excitatory\n amino acid receptors and were affected by but did not require\n NMDA receptor activation. Voltage clamp and current clamp\n recordings revealed abnormal bursts of low-amplitude action\n potentials in 36\\% of recorded neurons, while large, repetitive\n inhibitory potentials, mediated by GABAA receptors, were recorded\n in 90\\% of the neurons. Thus, prominent findings in this model\n include abnormalities of both excitatory and inhibitory activity.\n Since these changes in neuronal excitability resulted from a\n localized physical injury, they may resemble the changes that\n occur in acute posttraumatic epilepsy.\",\n journal = \"Epilepsia\",\n volume = 33,\n number = 2,\n pages = \"199--212\",\n month = mar,\n year = 1992,\n address = \"United States\",\n language = \"en\"\n}\n\n","author_short":["Troyer, M D","Blanton, M G","Kriegstein, A R"],"key":"Troyer1992-ro","id":"Troyer1992-ro","bibbaseid":"troyer-blanton-kriegstein-abnormalactionpotentialburstsandsynchronizedgabamediatedinhibitorypotentialsinaninvitromodeloffocalepilepsy-1992","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["abnormal","action","potential","bursts","synchronized","gaba","mediated","inhibitory","potentials","vitro","model","focal","epilepsy","troyer","blanton","kriegstein"],"title":"Abnormal action-potential bursts and synchronized, GABA-mediated inhibitory potentials in an in vitro model of focal epilepsy","year":1992}