@article{RN346,
   author = {Truin, L. S. and Kohler, S. and Heger, I. S. and van Boxtel, M. P. J. and Schram, M. T. and Backes, W. H. and Jansen, J. F. A. and van Dongen, Mmcjm and de Vries, N. K. and de Vries, H. and Eussen, Sjpm and Stehouwer, C. D. A. and de Vugt, M. E. and Deckers, K.},
   title = {Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study},
   journal = {Br J Psychiatry},
   pages = {1-9},
   note = {Truin, Lotte S
Kohler, Sebastian
Heger, Irene S
van Boxtel, Martin P J
Schram, Miranda T
Backes, Walter H
Jansen, Jacobus F A
van Dongen, Martien M C J M
de Vries, Nanne K
de Vries, Hein
Eussen, Simone J P M
Stehouwer, Coen D A
de Vugt, Marjolein E
Deckers, Kay
eng
England
Br J Psychiatry. 2023 Dec 18:1-9. doi: 10.1192/bjp.2023.159.},
   abstract = {BACKGROUND: High cognitive activity possibly reduces the risk of cognitive decline and dementia. AIMS: To investigate associations between an individual's need to engage in cognitively stimulating activities (need for cognition, NFC) and structural brain damage and cognitive functioning in the Dutch general population with and without existing cognitive impairment. METHOD: Cross-sectional data were used from the population-based cohort of the Maastricht Study. NFC was measured using the Need For Cognition Scale. Cognitive functioning was tested in three domains: verbal memory, information processing speed, and executive functioning and attention. Values 1.5 s.d. below the mean were defined as cognitive impairment. Standardised volumes of white matter hyperintensities (WMH), cerebrospinal fluid (CSF) and presence of cerebral small vessel disease (CSVD) were derived from 3T magnetic resonance imaging. Multiple linear and binary logistic regression analyses were used adjusted for demographic, somatic and lifestyle factors. RESULTS: Participants (n = 4209; mean age 59.06 years, s.d. = 8.58; 50.1% women) with higher NFC scores had higher overall cognition scores (B = 0.21, 95% CI 0.17-0.26, P < 0.001) and lower odds for CSVD (OR = 0.74, 95% CI 0.60-0.91, P = 0.005) and cognitive impairment (OR = 0.60, 95% CI 0.48-0.76, P < 0.001) after adjustment for demographic, somatic and lifestyle factors. The association between NFC score and cognitive functioning was similar for individuals with and without prevalent cognitive impairment. We found no significant association between NFC and WMH or CSF volumes. CONCLUSIONS: A high need to engage in cognitively stimulating activities is associated with better cognitive functioning and less presence of CSVD and cognitive impairment. This suggests that, in middle-aged individuals, motivation to engage in cognitively stimulating activities may be an opportunity to improve brain health.},
   keywords = {Dementias/neurodegenerative diseases
cognitive neuroscience
epidemiology
mild cognitive impairment
prevention},
   ISSN = {1472-1465 (Electronic)
0007-1250 (Linking)},
   DOI = {10.1192/bjp.2023.159},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/38105553},
   year = {2023},
   type = {Journal Article}
}

{"_id":"Fmdg8csyi4mDMWRHi","bibbaseid":"truin-kohler-heger-vanboxtel-schram-backes-jansen-vandongen-etal-associationsofanindividualsneedforcognitionwithstructuralbraindamageandcognitivefunctioningimpairmentcrosssectionalpopulationbasedstudy-2023","author_short":["Truin, L. S.","Kohler, S.","Heger, I. S.","van Boxtel, M. P. J.","Schram, M. T.","Backes, W. H.","Jansen, J. F. A.","van Dongen, M.","de Vries, N. K.","de Vries, H.","Eussen, S.","Stehouwer, C. D. A.","de Vugt, M. E.","Deckers, K."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Truin"],"firstnames":["L.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Heger"],"firstnames":["I.","S."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Dongen"],"firstnames":["Mmcjm"],"suffixes":[]},{"propositions":["de"],"lastnames":["Vries"],"firstnames":["N.","K."],"suffixes":[]},{"propositions":["de"],"lastnames":["Vries"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Eussen"],"firstnames":["Sjpm"],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]},{"propositions":["de"],"lastnames":["Vugt"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Deckers"],"firstnames":["K."],"suffixes":[]}],"title":"Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study","journal":"Br J Psychiatry","pages":"1-9","note":"Truin, Lotte S Kohler, Sebastian Heger, Irene S van Boxtel, Martin P J Schram, Miranda T Backes, Walter H Jansen, Jacobus F A van Dongen, Martien M C J M de Vries, Nanne K de Vries, Hein Eussen, Simone J P M Stehouwer, Coen D A de Vugt, Marjolein E Deckers, Kay eng England Br J Psychiatry. 2023 Dec 18:1-9. doi: 10.1192/bjp.2023.159.","abstract":"BACKGROUND: High cognitive activity possibly reduces the risk of cognitive decline and dementia. AIMS: To investigate associations between an individual's need to engage in cognitively stimulating activities (need for cognition, NFC) and structural brain damage and cognitive functioning in the Dutch general population with and without existing cognitive impairment. METHOD: Cross-sectional data were used from the population-based cohort of the Maastricht Study. NFC was measured using the Need For Cognition Scale. Cognitive functioning was tested in three domains: verbal memory, information processing speed, and executive functioning and attention. Values 1.5 s.d. below the mean were defined as cognitive impairment. Standardised volumes of white matter hyperintensities (WMH), cerebrospinal fluid (CSF) and presence of cerebral small vessel disease (CSVD) were derived from 3T magnetic resonance imaging. Multiple linear and binary logistic regression analyses were used adjusted for demographic, somatic and lifestyle factors. RESULTS: Participants (n = 4209; mean age 59.06 years, s.d. = 8.58; 50.1% women) with higher NFC scores had higher overall cognition scores (B = 0.21, 95% CI 0.17-0.26, P < 0.001) and lower odds for CSVD (OR = 0.74, 95% CI 0.60-0.91, P = 0.005) and cognitive impairment (OR = 0.60, 95% CI 0.48-0.76, P < 0.001) after adjustment for demographic, somatic and lifestyle factors. The association between NFC score and cognitive functioning was similar for individuals with and without prevalent cognitive impairment. We found no significant association between NFC and WMH or CSF volumes. CONCLUSIONS: A high need to engage in cognitively stimulating activities is associated with better cognitive functioning and less presence of CSVD and cognitive impairment. This suggests that, in middle-aged individuals, motivation to engage in cognitively stimulating activities may be an opportunity to improve brain health.","keywords":"Dementias/neurodegenerative diseases cognitive neuroscience epidemiology mild cognitive impairment prevention","issn":"1472-1465 (Electronic) 0007-1250 (Linking)","doi":"10.1192/bjp.2023.159","url":"https://www.ncbi.nlm.nih.gov/pubmed/38105553","year":"2023","bibtex":"@article{RN346,\n author = {Truin, L. S. and Kohler, S. and Heger, I. S. and van Boxtel, M. P. J. and Schram, M. T. and Backes, W. H. and Jansen, J. F. A. and van Dongen, Mmcjm and de Vries, N. K. and de Vries, H. and Eussen, Sjpm and Stehouwer, C. D. A. and de Vugt, M. E. and Deckers, K.},\n title = {Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study},\n journal = {Br J Psychiatry},\n pages = {1-9},\n note = {Truin, Lotte S\nKohler, Sebastian\nHeger, Irene S\nvan Boxtel, Martin P J\nSchram, Miranda T\nBackes, Walter H\nJansen, Jacobus F A\nvan Dongen, Martien M C J M\nde Vries, Nanne K\nde Vries, Hein\nEussen, Simone J P M\nStehouwer, Coen D A\nde Vugt, Marjolein E\nDeckers, Kay\neng\nEngland\nBr J Psychiatry. 2023 Dec 18:1-9. doi: 10.1192/bjp.2023.159.},\n abstract = {BACKGROUND: High cognitive activity possibly reduces the risk of cognitive decline and dementia. AIMS: To investigate associations between an individual's need to engage in cognitively stimulating activities (need for cognition, NFC) and structural brain damage and cognitive functioning in the Dutch general population with and without existing cognitive impairment. METHOD: Cross-sectional data were used from the population-based cohort of the Maastricht Study. NFC was measured using the Need For Cognition Scale. Cognitive functioning was tested in three domains: verbal memory, information processing speed, and executive functioning and attention. Values 1.5 s.d. below the mean were defined as cognitive impairment. Standardised volumes of white matter hyperintensities (WMH), cerebrospinal fluid (CSF) and presence of cerebral small vessel disease (CSVD) were derived from 3T magnetic resonance imaging. Multiple linear and binary logistic regression analyses were used adjusted for demographic, somatic and lifestyle factors. RESULTS: Participants (n = 4209; mean age 59.06 years, s.d. = 8.58; 50.1% women) with higher NFC scores had higher overall cognition scores (B = 0.21, 95% CI 0.17-0.26, P < 0.001) and lower odds for CSVD (OR = 0.74, 95% CI 0.60-0.91, P = 0.005) and cognitive impairment (OR = 0.60, 95% CI 0.48-0.76, P < 0.001) after adjustment for demographic, somatic and lifestyle factors. The association between NFC score and cognitive functioning was similar for individuals with and without prevalent cognitive impairment. We found no significant association between NFC and WMH or CSF volumes. CONCLUSIONS: A high need to engage in cognitively stimulating activities is associated with better cognitive functioning and less presence of CSVD and cognitive impairment. This suggests that, in middle-aged individuals, motivation to engage in cognitively stimulating activities may be an opportunity to improve brain health.},\n keywords = {Dementias/neurodegenerative diseases\ncognitive neuroscience\nepidemiology\nmild cognitive impairment\nprevention},\n ISSN = {1472-1465 (Electronic)\n0007-1250 (Linking)},\n DOI = {10.1192/bjp.2023.159},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/38105553},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Truin, L. S.","Kohler, S.","Heger, I. S.","van Boxtel, M. P. J.","Schram, M. T.","Backes, W. H.","Jansen, J. F. A.","van Dongen, M.","de Vries, N. K.","de Vries, H.","Eussen, S.","Stehouwer, C. D. A.","de Vugt, M. E.","Deckers, K."],"key":"RN346","id":"RN346","bibbaseid":"truin-kohler-heger-vanboxtel-schram-backes-jansen-vandongen-etal-associationsofanindividualsneedforcognitionwithstructuralbraindamageandcognitivefunctioningimpairmentcrosssectionalpopulationbasedstudy-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/38105553"},"keyword":["Dementias/neurodegenerative diseases cognitive neuroscience epidemiology mild cognitive impairment prevention"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["dementias/neurodegenerative diseases cognitive neuroscience epidemiology mild cognitive impairment prevention"],"search_terms":["associations","individual","need","cognition","structural","brain","damage","cognitive","functioning","impairment","cross","sectional","population","based","study","truin","kohler","heger","van boxtel","schram","backes","jansen","van dongen","de vries","de vries","eussen","stehouwer","de vugt","deckers"],"title":"Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study","year":2023}