@ARTICLE{Tsai2010-jd,
  title    = "Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear
              migration in neural stem cells",
  author   = "Tsai, Jin-Wu and Lian, Wei-Nan and Kemal, Shahrnaz and
              Kriegstein, Arnold R and Vallee, Richard B",
  abstract = "Radial glial progenitor cells exhibit bidirectional cell
              cycle-dependent nuclear oscillations. The purpose and underlying
              mechanism of this unusual 'interkinetic nuclear migration' are
              poorly understood. We investigated the basis for this behavior by
              live imaging of nuclei, centrosomes and microtubules in embryonic
              rat brain slices, coupled with the use of RNA interference (RNAi)
              and the myosin inhibitor blebbistatin. We found that nuclei
              migrated independent of centrosomes and unidirectionally away
              from or toward the ventricular surface along microtubules, which
              were uniformly oriented from the ventricular surface to the pial
              surface of the brain. RNAi directed against cytoplasmic dynein
              specifically inhibited nuclear movement toward the apical
              surface. An RNAi screen of kinesin genes identified Kif1a, a
              member of the kinesin-3 family, as the motor for basally directed
              nuclear movement. These observations provide direct evidence that
              kinesins are involved in nuclear migration and neurogenesis and
              suggest that a cell cycle-dependent switch between distinct
              microtubule motors drives interkinetic nuclear migration.",
  journal  = "Nat Neurosci",
  volume   =  13,
  number   =  12,
  pages    = "1463--1471",
  month    =  oct,
  year     =  2010,
  language = "en"
}

{"_id":"YN9qyr7YFxi3E4oNK","bibbaseid":"tsai-lian-kemal-kriegstein-vallee-kinesin3andcytoplasmicdyneinmediateinterkineticnuclearmigrationinneuralstemcells-2010","author_short":["Tsai, J.","Lian, W.","Kemal, S.","Kriegstein, A. R","Vallee, R. B"],"bibdata":{"bibtype":"article","type":"article","title":"Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells","author":[{"propositions":[],"lastnames":["Tsai"],"firstnames":["Jin-Wu"],"suffixes":[]},{"propositions":[],"lastnames":["Lian"],"firstnames":["Wei-Nan"],"suffixes":[]},{"propositions":[],"lastnames":["Kemal"],"firstnames":["Shahrnaz"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Vallee"],"firstnames":["Richard","B"],"suffixes":[]}],"abstract":"Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic rat brain slices, coupled with the use of RNA interference (RNAi) and the myosin inhibitor blebbistatin. We found that nuclei migrated independent of centrosomes and unidirectionally away from or toward the ventricular surface along microtubules, which were uniformly oriented from the ventricular surface to the pial surface of the brain. RNAi directed against cytoplasmic dynein specifically inhibited nuclear movement toward the apical surface. An RNAi screen of kinesin genes identified Kif1a, a member of the kinesin-3 family, as the motor for basally directed nuclear movement. These observations provide direct evidence that kinesins are involved in nuclear migration and neurogenesis and suggest that a cell cycle-dependent switch between distinct microtubule motors drives interkinetic nuclear migration.","journal":"Nat Neurosci","volume":"13","number":"12","pages":"1463–1471","month":"October","year":"2010","language":"en","bibtex":"@ARTICLE{Tsai2010-jd,\n title = \"Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear\n migration in neural stem cells\",\n author = \"Tsai, Jin-Wu and Lian, Wei-Nan and Kemal, Shahrnaz and\n Kriegstein, Arnold R and Vallee, Richard B\",\n abstract = \"Radial glial progenitor cells exhibit bidirectional cell\n cycle-dependent nuclear oscillations. The purpose and underlying\n mechanism of this unusual 'interkinetic nuclear migration' are\n poorly understood. We investigated the basis for this behavior by\n live imaging of nuclei, centrosomes and microtubules in embryonic\n rat brain slices, coupled with the use of RNA interference (RNAi)\n and the myosin inhibitor blebbistatin. We found that nuclei\n migrated independent of centrosomes and unidirectionally away\n from or toward the ventricular surface along microtubules, which\n were uniformly oriented from the ventricular surface to the pial\n surface of the brain. RNAi directed against cytoplasmic dynein\n specifically inhibited nuclear movement toward the apical\n surface. An RNAi screen of kinesin genes identified Kif1a, a\n member of the kinesin-3 family, as the motor for basally directed\n nuclear movement. These observations provide direct evidence that\n kinesins are involved in nuclear migration and neurogenesis and\n suggest that a cell cycle-dependent switch between distinct\n microtubule motors drives interkinetic nuclear migration.\",\n journal = \"Nat Neurosci\",\n volume = 13,\n number = 12,\n pages = \"1463--1471\",\n month = oct,\n year = 2010,\n language = \"en\"\n}\n\n","author_short":["Tsai, J.","Lian, W.","Kemal, S.","Kriegstein, A. R","Vallee, R. B"],"key":"Tsai2010-jd","id":"Tsai2010-jd","bibbaseid":"tsai-lian-kemal-kriegstein-vallee-kinesin3andcytoplasmicdyneinmediateinterkineticnuclearmigrationinneuralstemcells-2010","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["kinesin","cytoplasmic","dynein","mediate","interkinetic","nuclear","migration","neural","stem","cells","tsai","lian","kemal","kriegstein","vallee"],"title":"Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells","year":2010}