Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Tseng, S., Lin, S., Chen, J., Su, Y., Huang, H., Chen, C., Lin, P., & Chen, Y. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 10(6):2190–2202, March, 2004. ![Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex PURPOSE We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas. EXPERIMENTAL DESIGN RT-2 glioma cells were treated with resveratrol, and then cytotoxicity was assayed, apoptosis was measured by flow-activated cell sorter flow cytometry, and expression of vascular endothelial growth factor was measured by reverse transcription-PCR. Tumor size, animal survival time, and survival rate were followed in resveratrol-treated rats with s.c. or intracerebral gliomas. Furthermore, in vitro proliferation was assayed to explore the effect of resveratrol on the proliferation of ECV304 human umbilical vein endothelial cells. Expression of CD31 in resveratrol-treated gliomas was followed immunohistochemically to study the effect of resveratrol on the glioma-induced angiogenesis. RESULTS Resveratrol was demonstrated to exert cytotoxic effects and induce glioma cell apoptosis in a concentration- and time-dependent manner (P \textless 0.05). Resveratrol (40 mg/kg/day) exerted significant antitumor effects on s.c. tumors, including slower tumor growth rate, longer animal survival time, and higher animal survival rate (P \textless 0.05). In contrast, resveratrol affected intracerebral tumors at only an increased dose (100 mg/kg/day), prolonging animal survival (P \textless 0.05) without affecting survival rate. The expression of vascular endothelial growth factor in the glioma cells and the proliferation of ECV304 cells were inhibited by resveratrol in a concentration-dependent manner. Immunohistochemical analyses showed that the s.c. gliomas from resveratrol-treated rats had fewer microvessel densities than did control rats (P \textless 0.01). CONCLUSIONS Resveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.c. gliomas. Thus, resveratrol might be considered a possible treatment strategy for gliomas.
@article{tseng_resveratrol_2004,
title = {Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats},
volume = {10},
issn = {1078-0432},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15041740},
abstract = {PURPOSE
We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas.
EXPERIMENTAL DESIGN
RT-2 glioma cells were treated with resveratrol, and then cytotoxicity was assayed, apoptosis was measured by flow-activated cell sorter flow cytometry, and expression of vascular endothelial growth factor was measured by reverse transcription-PCR. Tumor size, animal survival time, and survival rate were followed in resveratrol-treated rats with s.c. or intracerebral gliomas. Furthermore, in vitro proliferation was assayed to explore the effect of resveratrol on the proliferation of ECV304 human umbilical vein endothelial cells. Expression of CD31 in resveratrol-treated gliomas was followed immunohistochemically to study the effect of resveratrol on the glioma-induced angiogenesis.
RESULTS
Resveratrol was demonstrated to exert cytotoxic effects and induce glioma cell apoptosis in a concentration- and time-dependent manner (P {\textless} 0.05). Resveratrol (40 mg/kg/day) exerted significant antitumor effects on s.c. tumors, including slower tumor growth rate, longer animal survival time, and higher animal survival rate (P {\textless} 0.05). In contrast, resveratrol affected intracerebral tumors at only an increased dose (100 mg/kg/day), prolonging animal survival (P {\textless} 0.05) without affecting survival rate. The expression of vascular endothelial growth factor in the glioma cells and the proliferation of ECV304 cells were inhibited by resveratrol in a concentration-dependent manner. Immunohistochemical analyses showed that the s.c. gliomas from resveratrol-treated rats had fewer microvessel densities than did control rats (P {\textless} 0.01).
CONCLUSIONS
Resveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.c. gliomas. Thus, resveratrol might be considered a possible treatment strategy for gliomas.},
number = {6},
urldate = {2012-01-03},
journal = {Clinical Cancer Research: An Official Journal of the American Association for Cancer Research},
author = {Tseng, Sheng-Hong and Lin, Swei-Ming and Chen, Jin-Cherng and Su, Yen-Hao and Huang, Hsin-Yi and Chen, Chia-Kang and Lin, Po-Yin and Chen, Yun},
month = mar,
year = {2004},
pmid = {15041740},
keywords = {Angiogenesis Inhibitors, Animals, Apoptosis, Cell Division, Cell Line, Cell Line, Tumor, Disease Models, Animal, Endothelium, Vascular, Flow Cytometry, Glioma, Kinetics, Neovascularization, Pathologic, Rats, Stilbenes, Umbilical Veins},
pages = {2190--2202},
}
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{"_id":"rStRDdbLeSD3HMYBa","bibbaseid":"tseng-lin-chen-su-huang-chen-lin-chen-resveratrolsuppressestheangiogenesisandtumorgrowthofgliomasinrats-2004","author_short":["Tseng, S.","Lin, S.","Chen, J.","Su, Y.","Huang, H.","Chen, C.","Lin, P.","Chen, Y."],"bibdata":{"bibtype":"article","type":"article","title":"Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats","volume":"10","issn":"1078-0432","url":"http://www.ncbi.nlm.nih.gov/pubmed/15041740","abstract":"PURPOSE We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas. EXPERIMENTAL DESIGN RT-2 glioma cells were treated with resveratrol, and then cytotoxicity was assayed, apoptosis was measured by flow-activated cell sorter flow cytometry, and expression of vascular endothelial growth factor was measured by reverse transcription-PCR. Tumor size, animal survival time, and survival rate were followed in resveratrol-treated rats with s.c. or intracerebral gliomas. Furthermore, in vitro proliferation was assayed to explore the effect of resveratrol on the proliferation of ECV304 human umbilical vein endothelial cells. Expression of CD31 in resveratrol-treated gliomas was followed immunohistochemically to study the effect of resveratrol on the glioma-induced angiogenesis. RESULTS Resveratrol was demonstrated to exert cytotoxic effects and induce glioma cell apoptosis in a concentration- and time-dependent manner (P \\textless 0.05). Resveratrol (40 mg/kg/day) exerted significant antitumor effects on s.c. tumors, including slower tumor growth rate, longer animal survival time, and higher animal survival rate (P \\textless 0.05). In contrast, resveratrol affected intracerebral tumors at only an increased dose (100 mg/kg/day), prolonging animal survival (P \\textless 0.05) without affecting survival rate. The expression of vascular endothelial growth factor in the glioma cells and the proliferation of ECV304 cells were inhibited by resveratrol in a concentration-dependent manner. Immunohistochemical analyses showed that the s.c. gliomas from resveratrol-treated rats had fewer microvessel densities than did control rats (P \\textless 0.01). CONCLUSIONS Resveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.c. gliomas. Thus, resveratrol might be considered a possible treatment strategy for gliomas.","number":"6","urldate":"2012-01-03","journal":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research","author":[{"propositions":[],"lastnames":["Tseng"],"firstnames":["Sheng-Hong"],"suffixes":[]},{"propositions":[],"lastnames":["Lin"],"firstnames":["Swei-Ming"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Jin-Cherng"],"suffixes":[]},{"propositions":[],"lastnames":["Su"],"firstnames":["Yen-Hao"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Hsin-Yi"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Chia-Kang"],"suffixes":[]},{"propositions":[],"lastnames":["Lin"],"firstnames":["Po-Yin"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Yun"],"suffixes":[]}],"month":"March","year":"2004","pmid":"15041740","keywords":"Angiogenesis Inhibitors, Animals, Apoptosis, Cell Division, Cell Line, Cell Line, Tumor, Disease Models, Animal, Endothelium, Vascular, Flow Cytometry, Glioma, Kinetics, Neovascularization, Pathologic, Rats, Stilbenes, Umbilical Veins","pages":"2190–2202","bibtex":"@article{tseng_resveratrol_2004,\n\ttitle = {Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats},\n\tvolume = {10},\n\tissn = {1078-0432},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/15041740},\n\tabstract = {PURPOSE\n\nWe wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas.\n\n\nEXPERIMENTAL DESIGN\n\nRT-2 glioma cells were treated with resveratrol, and then cytotoxicity was assayed, apoptosis was measured by flow-activated cell sorter flow cytometry, and expression of vascular endothelial growth factor was measured by reverse transcription-PCR. Tumor size, animal survival time, and survival rate were followed in resveratrol-treated rats with s.c. or intracerebral gliomas. Furthermore, in vitro proliferation was assayed to explore the effect of resveratrol on the proliferation of ECV304 human umbilical vein endothelial cells. Expression of CD31 in resveratrol-treated gliomas was followed immunohistochemically to study the effect of resveratrol on the glioma-induced angiogenesis.\n\n\nRESULTS\n\nResveratrol was demonstrated to exert cytotoxic effects and induce glioma cell apoptosis in a concentration- and time-dependent manner (P {\\textless} 0.05). Resveratrol (40 mg/kg/day) exerted significant antitumor effects on s.c. tumors, including slower tumor growth rate, longer animal survival time, and higher animal survival rate (P {\\textless} 0.05). In contrast, resveratrol affected intracerebral tumors at only an increased dose (100 mg/kg/day), prolonging animal survival (P {\\textless} 0.05) without affecting survival rate. The expression of vascular endothelial growth factor in the glioma cells and the proliferation of ECV304 cells were inhibited by resveratrol in a concentration-dependent manner. Immunohistochemical analyses showed that the s.c. gliomas from resveratrol-treated rats had fewer microvessel densities than did control rats (P {\\textless} 0.01).\n\n\nCONCLUSIONS\n\nResveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.c. gliomas. Thus, resveratrol might be considered a possible treatment strategy for gliomas.},\n\tnumber = {6},\n\turldate = {2012-01-03},\n\tjournal = {Clinical Cancer Research: An Official Journal of the American Association for Cancer Research},\n\tauthor = {Tseng, Sheng-Hong and Lin, Swei-Ming and Chen, Jin-Cherng and Su, Yen-Hao and Huang, Hsin-Yi and Chen, Chia-Kang and Lin, Po-Yin and Chen, Yun},\n\tmonth = mar,\n\tyear = {2004},\n\tpmid = {15041740},\n\tkeywords = {Angiogenesis Inhibitors, Animals, Apoptosis, Cell Division, Cell Line, Cell Line, Tumor, Disease Models, Animal, Endothelium, Vascular, Flow Cytometry, Glioma, Kinetics, Neovascularization, Pathologic, Rats, Stilbenes, Umbilical Veins},\n\tpages = {2190--2202},\n}\n\n","author_short":["Tseng, S.","Lin, S.","Chen, J.","Su, Y.","Huang, H.","Chen, C.","Lin, P.","Chen, Y."],"key":"tseng_resveratrol_2004","id":"tseng_resveratrol_2004","bibbaseid":"tseng-lin-chen-su-huang-chen-lin-chen-resveratrolsuppressestheangiogenesisandtumorgrowthofgliomasinrats-2004","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/15041740"},"keyword":["Angiogenesis Inhibitors","Animals","Apoptosis","Cell Division","Cell Line","Cell Line","Tumor","Disease Models","Animal","Endothelium","Vascular","Flow Cytometry","Glioma","Kinetics","Neovascularization","Pathologic","Rats","Stilbenes","Umbilical Veins"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/585595/collections/EZA9MKN6/items?key=KhA4GoMeOvxPn5tlpemkMrP3&format=bibtex&limit=100","dataSources":["mLRCv4BM3hCZt8ZRw"],"keywords":["angiogenesis inhibitors","animals","apoptosis","cell division","cell line","cell line","tumor","disease models","animal","endothelium","vascular","flow cytometry","glioma","kinetics","neovascularization","pathologic","rats","stilbenes","umbilical veins"],"search_terms":["resveratrol","suppresses","angiogenesis","tumor","growth","gliomas","rats","tseng","lin","chen","su","huang","chen","lin","chen"],"title":"Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats","year":2004}