Photoacoustic Microscopy of Microvascular Responses to Cortical Electrical Stimulation. Tsytsarev, V., Hu, S., Yao, J., Maslov, K., Barbour, D. L., & Wang, L. V. Journal of Biomedical Optics, 16(7):076002, July, 2011. Paper doi abstract bibtex Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.
@article{tsytsarev_photoacoustic_2011,
title = {Photoacoustic {Microscopy} of {Microvascular} {Responses} to {Cortical} {Electrical} {Stimulation}},
volume = {16},
issn = {1560-2281},
url = {https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-07/076002/Photoacoustic-microscopy-of-microvascular-responses-to-cortical-electrical-stimulation/10.1117/1.3594785.full?SSO=1},
doi = {10.1117/1.3594785},
abstract = {Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.},
language = {eng},
number = {7},
journal = {Journal of Biomedical Optics},
author = {Tsytsarev, Vassiliy and Hu, Song and Yao, Junjie and Maslov, Konstantin and {Barbour, D. L.} and Wang, Lihong V.},
month = jul,
year = {2011},
pmid = {21806263},
pmcid = {PMC3144972},
keywords = {Animals, Cerebrovascular Circulation, Electric Stimulation, Lasers, Solid-State, Mice, Microscopy, Acoustic, Microvessels, Optical Phenomena, Somatosensory Cortex, Vasoconstriction, Vasodilation},
pages = {076002},
}
Downloads: 0
{"_id":"TRW45qmA6dbeQt8Cr","bibbaseid":"tsytsarev-hu-yao-maslov-barbour-wang-photoacousticmicroscopyofmicrovascularresponsestocorticalelectricalstimulation-2011","author_short":["Tsytsarev, V.","Hu, S.","Yao, J.","Maslov, K.","Barbour, D. L.","Wang, L. V."],"bibdata":{"bibtype":"article","type":"article","title":"Photoacoustic Microscopy of Microvascular Responses to Cortical Electrical Stimulation","volume":"16","issn":"1560-2281","url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-07/076002/Photoacoustic-microscopy-of-microvascular-responses-to-cortical-electrical-stimulation/10.1117/1.3594785.full?SSO=1","doi":"10.1117/1.3594785","abstract":"Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.","language":"eng","number":"7","journal":"Journal of Biomedical Optics","author":[{"propositions":[],"lastnames":["Tsytsarev"],"firstnames":["Vassiliy"],"suffixes":[]},{"propositions":[],"lastnames":["Hu"],"firstnames":["Song"],"suffixes":[]},{"propositions":[],"lastnames":["Yao"],"firstnames":["Junjie"],"suffixes":[]},{"propositions":[],"lastnames":["Maslov"],"firstnames":["Konstantin"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Barbour, D. L."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Lihong","V."],"suffixes":[]}],"month":"July","year":"2011","pmid":"21806263","pmcid":"PMC3144972","keywords":"Animals, Cerebrovascular Circulation, Electric Stimulation, Lasers, Solid-State, Mice, Microscopy, Acoustic, Microvessels, Optical Phenomena, Somatosensory Cortex, Vasoconstriction, Vasodilation","pages":"076002","bibtex":"@article{tsytsarev_photoacoustic_2011,\n\ttitle = {Photoacoustic {Microscopy} of {Microvascular} {Responses} to {Cortical} {Electrical} {Stimulation}},\n\tvolume = {16},\n\tissn = {1560-2281},\n\turl = {https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-07/076002/Photoacoustic-microscopy-of-microvascular-responses-to-cortical-electrical-stimulation/10.1117/1.3594785.full?SSO=1},\n\tdoi = {10.1117/1.3594785},\n\tabstract = {Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Journal of Biomedical Optics},\n\tauthor = {Tsytsarev, Vassiliy and Hu, Song and Yao, Junjie and Maslov, Konstantin and {Barbour, D. L.} and Wang, Lihong V.},\n\tmonth = jul,\n\tyear = {2011},\n\tpmid = {21806263},\n\tpmcid = {PMC3144972},\n\tkeywords = {Animals, Cerebrovascular Circulation, Electric Stimulation, Lasers, Solid-State, Mice, Microscopy, Acoustic, Microvessels, Optical Phenomena, Somatosensory Cortex, Vasoconstriction, Vasodilation},\n\tpages = {076002},\n}\n\n","author_short":["Tsytsarev, V.","Hu, S.","Yao, J.","Maslov, K.","Barbour, D. L.","Wang, L. V."],"key":"tsytsarev_photoacoustic_2011","id":"tsytsarev_photoacoustic_2011","bibbaseid":"tsytsarev-hu-yao-maslov-barbour-wang-photoacousticmicroscopyofmicrovascularresponsestocorticalelectricalstimulation-2011","role":"author","urls":{"Paper":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-07/076002/Photoacoustic-microscopy-of-microvascular-responses-to-cortical-electrical-stimulation/10.1117/1.3594785.full?SSO=1"},"keyword":["Animals","Cerebrovascular Circulation","Electric Stimulation","Lasers","Solid-State","Mice","Microscopy","Acoustic","Microvessels","Optical Phenomena","Somatosensory Cortex","Vasoconstriction","Vasodilation"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/2607247/items?key=t9TdC3rOErveu1tiJ6HpRRuh&format=bibtex&limit=100","dataSources":["Fo9Jzk7YWDoEzAMys","bcA57xRhFo7t7CYWY"],"keywords":["animals","cerebrovascular circulation","electric stimulation","lasers","solid-state","mice","microscopy","acoustic","microvessels","optical phenomena","somatosensory cortex","vasoconstriction","vasodilation"],"search_terms":["photoacoustic","microscopy","microvascular","responses","cortical","electrical","stimulation","tsytsarev","hu","yao","maslov","barbour","wang"],"title":"Photoacoustic Microscopy of Microvascular Responses to Cortical Electrical Stimulation","year":2011}