Photoacoustic Microscopy of Microvascular Responses to Cortical Electrical Stimulation. Tsytsarev, V., Hu, S., Yao, J., Maslov, K., Barbour, D. L., & Wang, L. V. Journal of Biomedical Optics, 16(7):076002, July, 2011. ![Photoacoustic Microscopy of Microvascular Responses to Cortical Electrical Stimulation [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.
@article{tsytsarev_photoacoustic_2011,
title = {Photoacoustic {Microscopy} of {Microvascular} {Responses} to {Cortical} {Electrical} {Stimulation}},
volume = {16},
issn = {1560-2281},
url = {https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-07/076002/Photoacoustic-microscopy-of-microvascular-responses-to-cortical-electrical-stimulation/10.1117/1.3594785.full?SSO=1},
doi = {10.1117/1.3594785},
abstract = {Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.},
language = {eng},
number = {7},
journal = {Journal of Biomedical Optics},
author = {Tsytsarev, Vassiliy and Hu, Song and Yao, Junjie and Maslov, Konstantin and {Barbour, D. L.} and Wang, Lihong V.},
month = jul,
year = {2011},
pmid = {21806263},
pmcid = {PMC3144972},
keywords = {Animals, Cerebrovascular Circulation, Electric Stimulation, Lasers, Solid-State, Mice, Microscopy, Acoustic, Microvessels, Optical Phenomena, Somatosensory Cortex, Vasoconstriction, Vasodilation},
pages = {076002},
}
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