Methods for Equivalence and Noninferiority Testing. Tunes da Silva, G., Logan, B. R., & Klein, J. P. Biology of Blood and Marrow Transplantation, 15(1):120–127, January, 2009. ![Methods for Equivalence and Noninferiority Testing [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.
@article{tunes_da_silva_methods_2009-1,
title = {Methods for {Equivalence} and {Noninferiority} {Testing}},
volume = {15},
issn = {10838791},
url = {https://linkinghub.elsevier.com/retrieve/pii/S108387910800428X},
doi = {10.1016/j.bbmt.2008.10.004},
abstract = {Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.},
language = {en},
number = {1},
urldate = {2019-05-02},
journal = {Biology of Blood and Marrow Transplantation},
author = {Tunes da Silva, Gisela and Logan, Brent R. and Klein, John P.},
month = jan,
year = {2009},
pages = {120--127},
file = {Tunes da Silva et al. - 2009 - Methods for Equivalence and Noninferiority Testing.pdf:/Users/neil.hawkins/Zotero/storage/Y4AM3EML/Tunes da Silva et al. - 2009 - Methods for Equivalence and Noninferiority Testing.pdf:application/pdf},
}
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