Dissociations in processing past tense morphology: Neuropathology and behavioral studies. Tyler, L. K, deMornay-Davies , P., Anokhina, R., Longworth, C., Randall, B., & Marslen-Wilson, W. D J Cogn Neurosci, 14(1):79-94, 2002.
doi  abstract   bibtex   
Neuropsychological research showing that the regular ("jump-jumped") and irregular ("drive/drove") past tense inflectional morphology can dissociate following brain damage has been important in testing claims about the cognitive and neural status of linguistic rules. These dissociations have been interpreted as evidence for two different computational systems-a rule-based system underlying the processing of regulars and the irregulars being individually listed in the mental lexicon. In contrast, connectionist accounts claim that these dissociations can be modeled within a single system. Combining behavioral data from patients with detailed information about their neuropathology can, in principle, provide strong constraints on accounts of the past tense. In this study, we tested five nonfluent aphasic patients, all of whom had extensive left hemisphere (LH) damage involving the left inferior frontal gyrus and underlying structures, and four patients with semantic deficits following herpes simplex encephalitis (HSE) who had extensive damage to the inferior temporal cortex. These patients were tested in experiments probing past tense processing. In a large priming study, the nonfluent patients showed no priming for the regular past tense but significant priming for the irregulars (whereas controls show priming for both). In contrast, the HSE patients showed significantly impaired performance for the irregulars in an elicitation task. These patterns of behavioral data and neuropathology suggest that two separable but interdependent systems underlie processing of the regular and irregular past tense.
@Article{Tyler2002,
  author   = {Lorraine K Tyler and Paul deMornay-Davies and Rebekah Anokhina and Catherine Longworth and Billi Randall and William D Marslen-Wilson},
  journal  = {J Cogn Neurosci},
  title    = {Dissociations in processing past tense morphology: {N}europathology and behavioral studies.},
  year     = {2002},
  number   = {1},
  pages    = {79-94},
  volume   = {14},
  abstract = {Neuropsychological research showing that the regular ("jump-jumped")
	and irregular ("drive/drove") past tense inflectional morphology
	can dissociate following brain damage has been important in testing
	claims about the cognitive and neural status of linguistic rules.
	These dissociations have been interpreted as evidence for two different
	computational systems-a rule-based system underlying the processing
	of regulars and the irregulars being individually listed in the mental
	lexicon. In contrast, connectionist accounts claim that these dissociations
	can be modeled within a single system. Combining behavioral data
	from patients with detailed information about their neuropathology
	can, in principle, provide strong constraints on accounts of the
	past tense. In this study, we tested five nonfluent aphasic patients,
	all of whom had extensive left hemisphere (LH) damage involving the
	left inferior frontal gyrus and underlying structures, and four patients
	with semantic deficits following herpes simplex encephalitis (HSE)
	who had extensive damage to the inferior temporal cortex. These patients
	were tested in experiments probing past tense processing. In a large
	priming study, the nonfluent patients showed no priming for the regular
	past tense but significant priming for the irregulars (whereas controls
	show priming for both). In contrast, the HSE patients showed significantly
	impaired performance for the irregulars in an elicitation task. These
	patterns of behavioral data and neuropathology suggest that two separable
	but interdependent systems underlie processing of the regular and
	irregular past tense.},
  doi      = {10.1162/089892902317205348},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, Broca, Encephalitis, Herpes Simplex, Infarction, Middle Cerebral Artery, X-Ray Computed, 11798389},
}

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